Levels of interluekin-6 and its correlation with maternal outcome in patients of gestational diabetes mellitus

Ujjwala Anand, Manish Kumar, Rashmi B.


Background: Gestational diabetes mellitus (GDM) is a glucose tolerance disorder that occurs or is diagnosed for the first time during pregnancy. Objective was to see the levels of interluekin-6 and its correlation with maternal outcome in patients of gestational diabetes mellitus.

Methods: The source of data for the study is the antenatal patients attending the Outpatient Department or admitted in “Upper India Sugar Exchange Maternity Hospital”, Department of Obstetrics and Gynaecology, G.S.V.M. Medical College, Kanpur. This study was a prospective study done on 120 patients.

Results: Most patients in the study group belonged to the age group 20-24 years followed by age group 25-29 years. Level of interleukin-6 was significantly raised in gestational diabetes mellitus patients compared to non-gestational diabetes mellitus. 13.19% patients of GDM had PROM, which was only 6.5% in non GDM patients. 25.79% patients of GDM had preterm, which was only 12.8% in non GDM patients. 5.16% patients of GDM had polyhydramnios, which was only 2.64% in non GDM patients. 17.20% patients of GDM had IUGR, which was only 10.31% in non GDM patients.

Conclusions: Gestational diabetes is associated with various maternal complications i.e. preeclampsia, preterm, PROM, IUGR, polyhydramnios, increased operative morbidity, development of type 2 DM.


Interluekin-6, IUGR, Polyhydramnios, Preeclampsia, Preterm, PROM

Full Text:



O'Sullivan JB, Mahan CM. Criteria for the oral glucose tolerance test in pregnancy. Diabetes.1964;13:278-85.

Seshiah V, Balaji V, Balaji MS, Sanjeevi CB, Green A. Gestational diabetes mellitus in India. J Assoc Phys India. 2004;52:707-11.

Hod M. Clinical and experimental advances in diabetic embryopathy. Diabetic Rev Int. 1997;6:10- 4

Adams KM, Hongzhe L, Nelson RL, Ogbum PL, Danilenko-Dixon DR. Sequelae of unrecognized gestational diabetes. Am J Obstet Gynecol. 1998;178:132.

Damm P, Kuhl K, Bertelsen A, Molsted-Pedersen L. Predictive factors for the development of diabetes in women with previous gestational diabetes mellitus. Ani J Obstet Gynecol. 1992;167:607-16

Kaufmann RC, Schleyhahn FT, Hufhan DG, Amankwah KS. Gestational diabetes diagnostic cnteria: long term materna1 follow-up. Am J Obstel Gynecol. 1995;172:62.

Kjos SL, Peters RK, Xiang A, Thomas D, Schaefer U, Buchanan TA. Contraception and the risk of type 2 diabetes mellitus in Latina women with prior gestational diabetes mellitus. JAMA. 1998;280:533-8.

Silverman BL, Metzger BE, Cho NM, Loeb CA. Impaired glucose tolerance in adolescent offspring of diabetic mothers- relationship to fetal hyperinsulinism. Diabetes Care. 1995;18:611.

K Sreekanthan, A Belicita, k Rajendran, Anil Vijayakumar, Prevalence of Gestational Diabetes Mellitus in a Medical College in South India: A Pilot Study, Indian Journal of Clinical Practice, 2014, 25,(4), 342-347.

Rajput R, Yadav Y, Nanda S, Rajput M. Prevalence of gestational diabetes mellitus and associated risk factors at a tertiary care hospital in Haryana. Indian J Med Res. 2013;137(4):728-33.

Yang X, Hsu-Hage B, Zhang H, Yu L, Dong L, Li J, et al. Gestational diabetes mellitus in women of single gravidity in Tianjin City, China. Diabetes Care. 2002;25:847-51.

Keshavarz M, Cheung NW, Babaee GR, Moghadam HK, Ajami ME, Shariati M. Gestational diabetes in Iran: incidence, risk factors and pregnancy outcomes. Diabetes Res Clin Pract. 2005;69:279-86

Kalyani KR, Jajoo S, Hariharan C, Samal S. Prevalence of gestational diabetes mellitus, its associated risk factors and pregnancy outcomes at a rural setup in Central India. Int J Reprod Contracept Obstet Gynecol. 2014;3(1):219-24

Kalra P, Kachhwaha CP, Singh HV. Prevalence of gestational diabetes mellitus and its outcome in western Rajasthan. Indian J Endocrinol Metab. 2013;17(4):677-80.

Gajjar F, Maitra K. Intrapartum and perinatal outcomes in women with gestational diabetes and mild gestational hyperglycemia. J Obstet Gynaecol India. 2005;55:135-7.