Hypergonadotropic hypogonadism: looking beyond ovarian senescence

Authors

  • Richa Vatsa Department of Obstetrics and Gynaecology, AIIMS, New Delhi, India http://orcid.org/0000-0003-2835-1630
  • Vanita Suri Department of Obstetrics and Gynaecology, PGIMER, Chandigarh, Punjab, India
  • Neelam Choudahary Department of Obstetrics and Gynaecology, PGIMER, Chandigarh, Punjab, India
  • Aashima Arora Department of Obstetrics and Gynaecology, PGIMER, Chandigarh, Punjab, India
  • Shruti Sharma Department of Obstetrics and Gynaecology, PGIMER, Chandigarh, Punjab, India

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20210346

Keywords:

Gonadotropin resistant ovary syndrome, Infertility, In vitro maturation

Abstract

Gonadotropin resistant ovary syndrome (GROS) is a rare cause of primary infertility where ovarian reserve is present but they fail to respond to gonadotropin stimulation. This condition can be easily confused with premature ovarian insufficiency (POI) if thorough workup is not done as in both the cases serum FSH is high, but ovarian reserve is normal in GROS and low or absent in POI. So, we are presenting this case of GROS. A 28-year-old lady presented with oligomenorrhoea since menarche and primary infertility. On workup her serum FSH and LH levels were markedly elevated, serum estradiol was normal. Markers of ovarian reserve, ante Mullerian hormones (AMH) and antral follicle count (AFC), were normal. Her autoantibody assay was also normal. She did not respond to stimulation with high doses of gonadotropins (uHMG). Hypergonadotropic hypogonadism is not always POI. We should not miss diagnosis of GROS where it is possible to have own biological child by in vitro maturation of immature oocytes, whereas in POI donor oocyte is the only fertility option.

Author Biographies

Richa Vatsa, Department of Obstetrics and Gynaecology, AIIMS, New Delhi, India

Assistant professor, Department of obstetricsa and gynecology, AIIMS, New Delhi

Vanita Suri, Department of Obstetrics and Gynaecology, PGIMER, Chandigarh, Punjab, India

Professor and Head of Department

Neelam Choudahary, Department of Obstetrics and Gynaecology, PGIMER, Chandigarh, Punjab, India

Medical officer, Department of Obstetrics and gynaecology

Aashima Arora, Department of Obstetrics and Gynaecology, PGIMER, Chandigarh, Punjab, India

Assistant Professor, Department of Obstetrics and gynaecology

Shruti Sharma, Department of Obstetrics and Gynaecology, PGIMER, Chandigarh, Punjab, India

Lab technologist, Department of Obstetrics and gynaecology

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Published

2021-01-28

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Section

Case Reports