Published: 2016-12-27

Vulval leiomyoma: a rare clinical entity

Amudha P., Kalarani E., Karthika Devi A., Swathi M.


Vulval leiomyomas are rare benign tumors which arise from the smooth muscle cells within erectile tissue, blood vessel walls or round ligament remnants in labium majus. As they are rare, clinical diagnosis is often challenging. We report a case of 64 year old postmenopausal woman with a labial swelling of 3 months duration. It was clinically diagnosed as Bartholin`s gland cyst and intraoperatively the gross appearance was that of a leiomyoma and surgical excision was performed. Histopathological analysis confirmed the diagnosis of leiomyoma.


Vulval leiomyoma, Extrauterine leiomyoma, Vulval tumor

Full Text:



Szklaruk J, Tamm EP, Choi H, Varavithya V. MR imaging of common and uncommon large pelvic masses. RadioGraphics. 2003;23(2):403-24

ButtramVC Jr, Reiter RC. Uterine leiomyomata: etiology, symptomatology, and management. Fertil Steril. 1981;36(4):433-45

Guardiola MT, Dobin SM, Dal Cin P, Donner LR. Pericentric inversion (12) (p12q13-14) as the sole chromosomal abnormality in a leiomyoma of the vulva. Cancer Genet Cytogenet. 2010;199(1):21-3.

Kaufmanm RH, Gardner HL. Benign mesodermal tumors. Clin Obstet Gynecol. 1965;8(4):953-81

Fasih N, Parsad Shanbhogue AK, Macdonald DB, Fraser-Hill MA, Papadatos D, Kielar AZ. Leiomyomas beyond the uterus: unusual location rare manifestations. Radiographics. 2008;28:1931-48.

Nielsen GP, Rosenberg AE, Koerner FC, Young RH, Scully RE. Smooth-muscle tumors of the vulva: a clinicopathological study of 25 cases and review of the literature. Am J Surg Pathol. 1996;20(7):779-93.

Al Azzam M, Orrell JM, Vasey DP. Vulval leiomyoma with a myxoid hyaline stroma. J Obstet Gynaecol. 2004;24(8):936.

Murat ÖZ, Bülent KÖSTÜ, Emre ÖZGÜ. Leiomyoma of the vulva. The Journal of Gynecology - Obstetrics and Neonatology. 2013:1594-5.

Khunamornpong S, Sukpan K, Suprasert P, Shuangshoti S, Pintong J, Siriaunkgul S. Epstein-Barr virus-associated smooth muscle tumor presenting as a vulvar mass in an acquired immunodeficiency syndrome patient: a case report. Int J Gynecol Cancer. 2007;17(6):1333-7.

Aguilera Martinez V, Perez Santana ME, Avila Contreras ML, Mendoza E. Vulvar leiomyoma. Report of a case. Ginecol Obstet Mex. 2011;79:382-5.

Zhou J, Ha BK, Schubeck D, Chung-Park M. Myxoidepithelioid leiomyoma of the vulva: a case report. Gynecol Oncol. 2006;103:342-5.

Gonzalez-Bugatto F, Anon-Requena MJ, Lopez-Gurrero MA, Baez-Perea JM, Bartha JL, Hervias-Vivancos B. Vulvar leiomyosarcoma in Bartholin's gland area: a case report and literature review. Arch Gynecol Obstet. 2009;279:171-4.

Guven S, Esinler D, Salman MC, Gultekin M, Ayhan A. Recurrent vulval leiomyoma in postmenopausal patient mimicking vulval carcinoma. Journal of obstetrics and gynecology: the journal of the Institute of obstetrics and gynecology. 2005;25:7:732-5.