Published: 2021-02-24

Fertility preservation in non-seminomatous germ cell tumor: a case report

Nayana Patel, Niket Patel, Molina Patel, Yuvraj Jadeja, Harsha Bhadarka, Harmi Thakkar


Testicular germ cell tumors (TGCTs) are the most common malignancy in young men in their peak fertility years. It can intrinsically and permanently affect fertility potential of an individual. Clinicians are advised to offer Fertility Preservation before initiating the treatment. We present one such case of presence of Neoplasm in testis, where semen was cryopreserved before operating it for fertility preservation and biological pregnancy was achieved. On further investigations, presence of neoplasm on left testis was diagnosed. However, neoplasms of the testes are unique in that way they affect men at a young age and also have a high survival rates. Cryopreservation of ejaculated or surgically retrieved sperm is currently the only established method of fertility preservation for post-pubertal man. The incidence as well as rates for testicular cancers have remained relatively low and if presented early on, can be cured and has good survival rates. Fertility awareness must be raised amongst the oncologist, gynecologist and patients.


Testicular cancers, Fertility preservation, Testicular germ cell tumors, Non-seminomatous tumors

Full Text:



Cheng L, Albers P, Berney DM, Feldman DR, Daugaard G, Gilligan T et al. Testicular cancer. Nat Rev Dis Primers. 2018;4(1):29.

Trama A, Foschi R, LarraƱaga N, Sant M, Fuentes-Raspall R, Serraino D et al. EUROCARE-5 Working Group:. Survival of male genital cancers (prostate, testis and penis) in Europe 1999-2007: Results from the EUROCARE-5 study. Eur J Cancer. 2015;51(15):2206-216.

Williamson SR, Delahunt B, Magi-Galluzzi C, Algaba F, Egevad L, Ulbright TM et al. Members of the ISUP Testicular Tumour Panel. The World Health Organization 2016 classification of testicular germ cell tumours: a review and update from the International Society of Urological Pathology Testis Consultation Panel. Histopathology. 2017;70(3):335-46.

Bosl GJ, Motzer RJ. Testicular germ-cell cancer. N Engl J Med. 1997;337(4):242-53.

Einhorn LH. Treatment of testicular cancer: a new and improved model. J Clin Oncol. 1990;8(11):1777-81.

Patil M, Reddy P. Fertility Preservation in Testicular Seminoma. Oncofert J. 2018;1(2).

Murray MJ, Huddart RA, Coleman M. The present and the future of serum diagnostic tests for testicular germ cell tumors. Nat Kevvrol. 2016;13(12):715-25.