Spontaneous pregnancy following post in vitro fertilization ruptured tubal ectopic pregnancy

Authors

  • Kirty Nahar Department of Obstetrics and Gynecology, Apollo Hospital International ltd., Ahmedabad, Gujarat, India
  • Nikita Nahar Smt. NHL Municipal, Medical College, Ahmedabad, Gujarat, India

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20204847

Keywords:

Ectopic pregnancy, Salpingectomy, Assited reproductive techniques, Invitro fertilization, Embryo transfer

Abstract

Ectopic pregnancy (EP) is a dramatic life threatening event in a woman’s reproductive life, especially after a long, expensive and difficult course of treatment for infertility. EP accounts around 1–2% of all natural conceptions, and this prevalence increases following assisted reproductive techniques, to range between 2.1% and 8.6% and it can reach up to 11% in women with tubal factors infertility history. A 32 year old female, primigravida presented at emergency department of Apollo Hospitals, Ahmedabad with complaints of amenorrhoea 2 months, severe pain abdomen associated with vomiting, difficulty in breathing and bleeding per vagina on and off. She was a case of primary infertility with polycystic ovary syndrome (PCOS) who had conceived after difficulty with in vitro fertilization (IVF), resulted in ruptured right tubal ectopic pregnancy. She underwent exploratory laparotomy followed by removal of right ectopic pregnancy, right salpingectomy and peritoneal lavage. Early diagnosis, timely intervention and prompt surgical management could save the patient’s life. Later on she conceived spontaneously and had an eventful and complicated pregnancy. She presented at 35 weeks of pregnancy with preterm labour pain and underwent emergency caesarean section for fetal distress. She delivered a healthy male child and had a successful obstetric outcome. Diagnosis of ruptured tubal ectopic pregnancy is made based on patient’s history, clinical acumen, serum beta human chorionic gonadotropin (hCG) levels and pelvic ultrasound. Ectopic pregnancy should be suspected in patients with an adnexal mass even in absence of risk factors. Clinicians must be alert to the fact that assisted reproductive techniques as a treatment for infertility can result into ectopic pregnancy. This case highlights the fact that patient who underwent IVF treatment resulting in ruptured tubal ectopic pregnancy can have spontaneous conception and a successful obstetric outcome.

Author Biography

Kirty Nahar, Department of Obstetrics and Gynecology, Apollo Hospital International ltd., Ahmedabad, Gujarat, India

Consultant obst &gynaecologist 

Department of obst @gynaecology

apollo hospitals internationals ltd

Ahmedabad Gujarat India 

References

Khan KS, Wojdyla D, Say L, Gulmenzoglu AM, van Look PF. WHO analysis of causes of maternal death: a systematic review. Lancet. 2006;367:1066-74.

Tal S, Einat PS, Eylon L, Ofer F, Adrian E. Unusual case of recurrent heterotopic pregnancy after bilateral salpingectomy and literature review. RBM Online. 2013;26:59-61.

Clayton HB, Schieve LA, Peterson HB, Jamieson DJ, Reynolds MA, Wright VC. Ectopic pregnancy risk with assisted reproductive technology procedures. Obstet Gynecol. 2006;107:595-604.

Chang HJ, Suh CS. Ectopic pregnancy after assisted reproductive technology: what are the risk factors? Curr Opin Obstet Gynecol. 2010;22:202-7.

Nazari A, Askari HA, Check JH, O'Shaughnessy A. Embryo transfer technique as a cause of ectopic pregnancy in in vitro fertilization. Fertil Steril. 1993;60:919-21.

Li W, Wang G, Lin T, Sun W. Misdiagnosis of bilateral tubal pregnancy: a case report. J Med Case Rep. 2014;8:342.

Jena SK, Singh S, Nayak M, Das L, Senapati S. Bilateral simultaneous tubal ectopic pregnancy: a case report, review of literature and a proposed management algorithm. J Clin Diagn Res. 2016;10(3):QD01-3.

Hortu I, Akman L, Akdemir A, Ergenoglu M, Yeniel O, Sendag F. Management of ectopic pregnancy in unusual locations: five-year experience in a single center. J Clin Exp Invest. 2017;8(3):90-5.

Sugawara N, Sato R, Kato M, Manome T, Kimura Y, Araki Y, et al. Bilateral tubal pregnancies after a single-embryo transfer. Reprod Med Biol. 2017;16(4):396-400.

Mains L, Van Voorhis BJ. Optimizing the technique of embryo transfer. Fertil Steril. 2010;94:785-90.

Fanchin R, Ayoubi JM, Righini C, Olivennes F, Schonauer LM, Frydman R. Uterine contractility decreases at the time of blastocyst transfers. Hum Reprod. 2001;16:1115-9.

Schoolcraft WB, Surrey ES, Gardner DK. Embryo transfer: techniques and variables affecting success. Fertil Steril. 2001;76:863-70.

Milki AA, Jun SH. Ectopic pregnancy rates with day 3 versus day 5 embryo transfer: a retrospective analysis. BMC Pregnancy Childbirth. 2003;3:7.

Steptoe PC, Edwards RG. Reimplantation of a human embryo with subsequent tubal pregnancy. Lancet. 1976;1:880-2.

Pope CS, Cook EK, Arny M, Novak A, Grow DR. Influence of embryo transfer depth on in vitro fertilization and embryo transfer outcomes. Fertil Steril. 2004;81:51-8.

Ishihara O, Kuwahara A, Saitoh H. Frozen-thawed blastocyst transfer reduces ectopic pregnancy risk: an analysis of single embryo transfer cycles in Japan. Fertil Steril. 2011;95:1966-9.

Shapiro BS, Daneshmand ST, De Leon L, Garner FC, Aguirre M, Hudson C. Frozen-thawed embryo transfer is associated with a significantly reduced incidence of ectopic pregnancy. Fertil Steril. 2012;98:1490-4.

Andres MP, Campillos, Lapresta, Lahoz, Crespo R, Tobajas J. Management of ectopic pregnancies with poor prognosis through USG guided intrasacular injection of methotrexate, series of 14 cases. Arch Gynecol Obstet. 2012;285:529-33.

Lesny P, Killick SR, Robinson J, Raven G, Maguiness SD. Junctional zone contractions and embryo transfer: is it safe to use a tenaculum? Hum Reprod. 1999;14:2367-70.

Fanchin R, Righini C, Olivennes F, Taylor S, de Ziegler D, Frydman R. Uterine contractions at the time of embryo transfer alter pregnancy rates after in-vitro fertilization. Hum Reprod. 1998;13:1968-74.

Mascarenhas MN, Flaxman SR, Boerma T, Vanderpoel S, Stevens GA. National, regional, and global trends in infertility prevalence since 1990: a systematic analysis of 277 health surveys. PLoS Med. 2012;9(12):1001356.

Jurkovic D, Wilkinson H. Diagnosis and management of ectopic pregnancy. BMJ. 2011;342:d3397.

Sivalingam VN, Duncan WC, Kirk E, Shephard LA, Horne AW. Diagnosis and management of ectopic pregnancy. J Fam Plann Reprod Health Care. 2011;37:231-40.

Goldzieher JW, Green JA. Clinical and biochemical features of polycystic ovarian disease. Fertil Steril. 1963;14:631-53.

Franks S. Polycystic ovary syndrome. N Engl J Med. 1989;333:853-61.

Carmina E, Lobo RA. Do hyperandrogenic women with normal menses have polycystic ovary syndrome? Fertil Steril. 1999;71:319-22.

Pasquali R, Antenucci D, Casimirri F. Clinical and hormonal characteristics of obese amenorrheic hyperandrogenic women before and after weight loss. J Clin Endocrinol Metab. 1989;68:173-9.

Huber-Bucholz MM, Carey DGP, Norman RJ. Restoration of reproductive potential by lifestyle modification in obese polycystic ovary syndrome. J Clin Endocrinol Metab. 1999;84:1470-4.

Moghetti P, Castello R, Negri C, Tosi F, Perrone F, Caputo M, Zanolin E, Muggeo M. Metformin effects on clinical features, endocrine and metabolic profiles, and insulin sensitivity in polycystic ovary syndrome: a randomized, double–blind, placebo–controlled 6–month trial, followed by open, long–term clinical evaluation. J Clin Endocrinol Metab. 2000;85:139-46.

Downloads

Published

2020-10-27

Issue

Section

Case Reports