DOI: http://dx.doi.org/10.18203/2320-1770.ijrcog20204803

Major congenital malformations of foetus: a bane in pregnancy

D. M. Christe, D. Mohana, S. Shobha

Abstract


Background: The aim of the study was to find out the numbers of women presenting with pregnancy complicating with major congenital anomalies of the fetus.

Methods: This study was conducted over a period of fifteen months in the year 2018-2019. The types of congenital anomalies were that of the central nervous system, cardiac, renal, gastrointestinal, skeleto-muscular, hydrops foetalis, chromosomal, single umbilical artery and other multiple anomalies. Other variables regarding the age group of the mother, gravida, parity and gestational age at which the pregnancy was terminated was also noted.

Results: A total of 212 pregnancies were diagnosed with major congenital anomalies of fetus and opted for termination. Malformations of the central nervous system (CNS) of fetus, formed the largest group of 56.6%, and fetal gastrointestinal malformations and fetal renal anomalies occupied the second major groups forming 11.8% and 11.3% respectively. The age group of women ranged between 23 years to 38 years. The largest group of pregnant women with fetal malformations were aged between 23-27 years. Primigravida with zero parity women were 60.4% of the total group of women with major fetal anomalies.

Conclusions: Maximum number of congenital anomalies were seen in primigravida and para one mothers. Genetic counseling should be offered for women at clinics, before planning further pregnancy. Facilities should be made available for poor people from remote areas for early detection of congenital anomalies.


Keywords


Congenital malformation, Fetus, Pregnancy

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References


World Health Organization. Fact Sheet .Congenital Anomalies. 2016. Available at: https://www.who.int/news-room/fact-sheets/detail/cogenital-anomalies. Accessed on: 13 November 2019.

Cortés F, Faundes V, Mellado C, Passalacqua C. Congenital anomalies of poor prognosis. Genetics Consensus Committee. Medicine. 2019;98(33):16822.

P.Bhide and A.Kar A national estimate of the birth prevalence of congenital anomalies in India: systematic review and meta-analysis. BMC Pediatr. 2018; 18: 175. doi: 10.1186/s12887-018-1149-0

Incidence of congenital anomalies in a rural population of Jammu - A prospective study A. Anjum, K. Dinesh, D. Deepika, D.Nasib C .: 2018 | Vol.: 62 | Iss.: 3 | Page: 188-192.

Kosinski P, Brawura Biskupski Samaha R, Lipa M, Wielgos M, Kohl T. Contemporary management of prenatally diagnosed spina bifida aperta - an update. Ginekol Pol. 2018;89(11):637-41.

Conner P, Vejde JH, Burgos CM. Accuracy and impact of prenatal diagnosis in infants with omphalocele. Pediatr Surg Int. 2018;34(6):629-33.

Boyle B, Addor MC, Arriola L, Barisic I. Estimating Global Burden of Disease due to congenital anomaly. Arch Dis Child Fetal Neonatal Ed. 2018;103(1):22-8.

Darlison MW, Modell B. Estimates of global and regional prevalence of neural tube defects for 2015. Ann N Y Acad Sci. 2018;1414(1):31-46.

de Groot-van der Mooren MD, Tamminga S, Oepkes D, Weijerman ME, Cornel MC. Older mothers and increased impact of prenatal screening: stable livebirth prevalence of trisomy 21 in the Netherlands for the period 2000-2013. Eur J Hum Genet. 2018;26(2):157-65.

The American College of Obstetricians and Gynecologists. Practice Bulletin Second-Trimester Abortion. Obstet Gynaecol. 2013;121(6):1394-406.

Chima SC, Mamdoo F. Ethical and legal dilemmas around termination of pregnancy for severe fetal anomalies: A review of two African neonates presenting with ventriculomegaly and holoprosencephaly. Niger J Clin Pract. 2015;18:31‐9.

Svenaeus F. Phenomenology of pregnancy and the ethics of abortion .The phen Med Health Care Philos. 2018;21(1):77-87.

Bing H, Ying L, Yi T, Xueling Q. Clinical analysis of prenatal ultrasound diagnosis of fetal cardiovascular malformations in the first and second trimesters of pregnancy. Medicine. 2019;98(33):16822.

Kamranpour B, Noroozi M, Bahrami M. Supportive needs of women who have experienced pregnancy termination due to fetal abnormalities: a qualitative study from the perspective of women, men and healthcare providers in Iran. BMC Public Health. 2019;19:507.

Jortveit J, Wik G, Odegaard JS, Sitras V. Diagnosis of severe congenital heart defects in Norway 2016.Tidsskr Nor Laegeforen. 2019;139(2).

Bhide P, Gund P, Kar A. Prevalence of Congenital Anomalies in an Indian Maternal Cohort: Healthcare, Prevention, and Surveillance Implications. PLoS One. 2016;10(11):0166408.

Marginean C, Sasarean V, Marginean CO. Prenatal diagnosis of cleft lip and cleft lip palate. Med Ultrason. 2018;20(4):531-5.

Hill M, Barrett A, Choolani M. Has noninvasive prenatal testing impacted termination of pregnancy and live birth rates of infants with Down syndrome? Prenat Diagn. 2017;37(13):1281-90.

Kashyap N, Pradhan M, Singh N, Yadav S. Early Detection of Fetal Malformation, A Long Distance Yet to Cover! Present Status and Potential of First Trimester Ultrasonography in Detection of Fetal Congenital Malformation in a Developing Country: Experience at a Tertiary Care Centre in India. J Pregnancy. 2015;623059.