An observational study of clinical profile and outcome of syphilis infection during pregnancy in the tertiary care center

Pooja Gangwar, Arti Jhinwal, Preksha Gupta, Eshu Dixit, Suchita Bajaj


Background: Syphilis is a sexually transmitted disease (STD) caused by the bacterium treponema pallidum, but little is known about its mechanism of action. In pregnancy it leads to adverse outcomes among more than half of the women with active disease, including early fetal loss, stillbirth, prematurity, low birth weight, neonatal and infant death.

Methods: It is an observational study in the department of obstetrics and gynecology Mahatma Gandhi Memorial Medical College Maharaja Yashwant Rao Hospital, Indore between January 2014 to December 2015 total 20870. In Include written informed consent, All the patients attending STI/RTI clinic with clinical diagnosis of STD. In Exclusion criteria include patients not give informed consent. Case definition: All VDRL + TPHA positive patients.

Results: Out of 20870 females on which VDRL was performed 77 (0.036%) were found to be positive. The seroprevalence at study hospital thus came out to be 0.036%. These were further confirmed by TPHA and 73 (94.8%) out of 77 samples were positive. A total agreement was seen between TPHA and VDRL with a titer of 1 in 8 and above. Among total 20870 screened females, 77% (16101) were ANC patients of which 26 cases out of 77 that is 33.76% females were syphilis positive.

Conclusions: Low prevalence of syphilis in pregnant women and adult general population is very encouraging. participation of people and public health approach to promote awareness of syphilis among physicians and populations at risk in India are very urgently needed to avoid the adverse consequences which could result from undiagnosed or improper treatment.


Congenital syphilis, Reproductive tract infection, Sexually transmitted infections, Syphilis in pregnancy

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Berman SM. Maternal syphilis: pathophysiology and treatment. Bulletin WHO. 2004;82(6):433-8.

Ingall D, Sánchez PJ. Syphilis in infectious diseases of the fetus and newborn infant, Remington JS and Klein JO, Eds., 5th ed. W.B. Saunders, Philadelphia; 2001: 643-81.

Centers for disease control and prevention national overview of sexually transmitted diseases (STDs), 2010. Available at: Accessed on 12th May 2020.

World Health Organization, The global elimination of congenital syphilis: rationale and strategy for action, 2007. Available at:, 2007. Accessed on 14th May 2020.

Chesson HW, Collins D, Koski K. Formulas for estimating the costs averted by sexually transmitted infection (STI) prevention programs in the United States. Cost Effective Resource Allocat. 2008;6(1):10.

Blandford JM, Gift TL. The cost-effectiveness of single-dose azithromycin for treatment of incubating syphilis. Sexual Transmit Dis. 2003;30(6):502-8.

Workowski KA, Berman S. Sexually transmitted diseases treatment guidelines. Morb Mort Weekly Rep. 2010;59(12):1-113.

Centers for Disease Control and Prevention, Syphilis-CDC Fact Sheet, 2012. Available at: html. Accessed on 12th May 2020.

Centers for disease control and prevention, “congenital syphilis-United States, 2003-2008,” Morb Mort Weekly Rep. 2010;59(14):413-7.

Centers for disease control and prevention, sexually transmitted diseases surveillance, 2010. Available at: Accessed on 18th May 2020.

World Health Organization, “Towards eliminating congenital syphilis,” Progress Report, 2011. Available at: /topics/rtis/GlobalData_cs_pregnancy2011.pdf. Accessed on 24th May 2020.

World Health Organization, Regional Office for Europe. Sexually transmitted infections, 2012. Available at: TabID=284849. Accessed on 18th May 2020.

Tridapalli E, Capretti MG, Sambri V, Marangoni A, Moroni A, D’Antuono A, et al. Prenatal syphilis infection is a possible cause of preterm delivery among immigrant women from eastern Europe. Sexual Transmit Infect. 2007;83(2):102-5.

Khan S, Menezes GA, Dhodapkar R, Harish BN. Seroprevalence of syphilis in patients attending a tertiary care hospital in Southern India. Asian Pacific J Trop Biomed. 2014;4(12):995-7.

Bhalla P, Chawla R, Garg S, Singh MM, Raina U, Bhalla R, et al. Prevalence of bacterial vaginosis among women in Delhi, India. Indian J Med Res. 2007;125:167-72.

Chanola R, Binalla P, Garg S, Singh MM, Bhalla K. Community based study on sero-prevalence of syphilis in New Delhi (India). J Commun Dis. 2004;36:205-11.

Shah SA, Kristensen S, Memon MA, Usman G, Ghazi A, John R, et al. Prevalence of syphilis among antenatal clinic attendees in Karachi: imperative to begin universal screening in Pakistan. J Pak Med Ass. 2011;61(10):993-7.