DOI: http://dx.doi.org/10.18203/2320-1770.ijrcog20203329

A prospective clinical trial to evaluate the prevalence of thyroid disorder among pregnant women and obstetrical and fetal outcome in a tertiary health centre located in central India

Manjari G. Jain, Neeraj K. Jain, Mita Mazumdar

Abstract


Background: A prospective clinical trial to evaluate the prevalence of thyroid disorder among pregnant women and obstetrical and fetal outcome was done in a tertiary health centre (RKDF Medical College and Research Centre, Bhopal) located in central India.

Methods: This prospective study was carried out in antenatal women in their first trimester attending antenatal OPD in RKDF Medical College and Research Centre, Bhopal, Madhya Pradesh to know the prevalence of thyroid disorder and its association with pregnancy outcome.

Results: In this study prevalence of thyroid disorder was 12.4%, subclinical hypothyroidism 7.2%, overt hypothyroidism 3.4%, subclinical hyperthyroidism 1.4%, overt hyperthyroidism 0.4%. Thyroid disorder is responsible for several obstetrical and fetal complication like pre-eclampsia, preterm delivery, abortion, IUGR and low birth weight.

Conclusions: Thyroid disorder associated with poor obstetrical outcome and fetal complication. so timely diagnosis and treatment is required. Universal screening should be preferred over high-risk screening because of high prevalence of the disease in India.


Keywords


Hyperthyroidism, Overt hypothyroidism, Overt hyperthyroidism, Pregnant women, Subclinical hypothyroidism, Subclinical, Thyroid disorder

Full Text:

PDF

References


Vaidya B. Management of hypothyroidism in pregnancy: we must do better. Clin Endocrinol. 2013;78:342-3.

Milanesi A, Brent GA. Management of hypothyroidism in pregnancy. Curr opin Endocr, Diab andobes. 2011;18:304-9.

Ian Donald's, Practical obstetric problems, 6th edition, Delhi, India: Renu Misra; 2012:177.

Sutandar M, Garcia-Bournissen F, Koren G. Hypothyroidism in pregnancy. J Obstet Gynaecol Can. 2007;29(4):354-6.

Smallridge RC, Ladenson PW. Hypothyroidism in pregnancy: consequences to neonatal health. J Clin Endor Metab. 2001;86(6):2349-53.

Ajmani SN, Aggarwal D, Bhatia P, Sharma M, Sarabhai V, Paul M. Prevalence of overt and subclinical thyroid dysfunction among pregnant women and its effect on maternal and fetal outcome. The J Obstet Gynaecol India. 2014;64(2):105-10.

Taghavi M, Sughafi N, Shirin S. Outcome of thyroid dysfunction in pregnancy in Mashhad, Iran. Inl J Endocrinol Metab. 2009;2:82-5.

Wang W, Teng W, Shan Z, Wang S, Li J, Zhu L, et al. The prevalence of thyroid disorder during early pregnancy in China: the benefits of universal screening in the first trimester of pregnancy. Eur J Endocrinol. 2011;164:263-8.

Thanuja PM, Rajgopal K. Thyroid dysfunction in pregnancy and its maternal. J Dent Med

Sci. 2014;13(1):11-5.

Goel V, Nanda S, Rajput M, Seth S. Prevalence of thyroid dysfunction among women during the first trimester of pregnancy at a tertiary care hospital in Haryana. Inl J Endocrinol Metab. 2015;19(3):416-9.

Sahu MT, Das V, Mittal S, Agarwal A, Sahu M. Overt and subclinical thyroid dysfunction among Indian pregnant women and its effect on maternal and fetal outcome. Arch Gynaecol Obstet. 2010;281(2):215-20.

Leung AS, Millar LK, Kooning PP, Montorom, Mestman J. Perinatal outcome in hypothyroid pregnancies. Obstetric Gynaecol. 1993;81(3):349-53.