A comparative study between nifedipine and isoxsuprine in the suppression of preterm labor pain

Susheela Khoiwal, Vandana Patidar, Radha Rastogi, Bharat Tailor


Background: A prospective study was conducted to compare the effectiveness of Nifedipine and Isoxsuprine in suppression of preterm labour pain as tocolytics drug. As preterm labour pain is major contributor for perinatal morbidity and mortality. The aims of this study were to assess the effect of nifedipine and isoxsuprine in threatened preterm labour with the aim of preventing preterm birth and its sequelae.

Methods: This study was conducted on 100 patients coming to Pannadhay Rajkiya Mahila Chikitsalaya, RNT Medical College, Udaipur and attending OPD and IPD with complain of uterine contractions between 28-36 weeks of gestation.

Results: Nifedipine was more effective than isoxsuprine hydrochloride as tocolytic agent.

Conclusions: There is high incidence of preterm labour in India which leads to neonatal morbidity and mortality. Nifedipine is a better tocolytic drug compared to isoxsuprine hydrochloride.


Isoxsuprine, Nifedipine, Preterm labor pain, Tocolytic drug

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