DOI: http://dx.doi.org/10.18203/2320-1770.ijrcog20202762

Unusual metastatic sex cord stromal tumor - staging and response assessment

Namita Agrawal, Tarun Kumar Jain, Guman Singh, Hemant Malhotra, Ajay Yadav

Abstract


Metastatic sex cord stromal tumor (SCST) is rare and contributing <1% of ovarian tumors. A 42-year-old female presented with lower abdominal pain for 2 months. Ultrasonography revealed masses in the abdominal and pelvic. USG guided biopsy from the pelvic mass revealed SCST. For staging, whole body F-18 fluorodeoxyglucose positron emission tomography-computed tomography was performed and revealed heterogenous mildly FDG avid retroperitoneal and bilateral pelvic masses with lung nodules. To confirm the nature of the lung nodule; PET-CT guided biopsy performed and revealed metastatic SCST. After three cycle of chemotherapy, clinical, biochemical and imaging show partial response to treatment.


Keywords


F-18 fluorodeoxyglucose positron emission tomography-computed tomography, Metastatic sex cord stromal tumor, Metabolic biopsy

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References


Horta M, Cunha TM. Sex cord-stromal tumors of the ovary: a comprehensive review and update for radiologists. Diagn Interv Radiol. 2015;21(4):277-86.

Haroon S, Zia A, Idrees R, Memon A, Fatima S, Kayani N. Clinicopathological spectrum of ovarian sex cord-stromal tumors; 20 years’ retrospective study in a developing country. J Ovarian Res. 2013;6:87.

Shim SH, Kim DY, Lee SW, Park JY, Kim JH, Kim YM, et al. Laparoscopic management of early-stage malignant non-epithelial ovarian tumors: surgical and survival outcomes. Int J Gynecol Cancer. 2013;23:249-55.

Hanley KZ, Mosunjac MB. Practical review of ovarian sex cord-stromal tumors. Surg Pathol Clin. 2019;12:587-620.

Gupta N, Yadav M, Gupta V, Chaudhary D, Patne SCU. Distribution of various histopathological types of ovarian tumors: a study of 212 cases from a tertiary care center of Eastern Uttar Pradesh. J Lab Physicians. 2019;11(1):75-81.

Thrall MM, Paley P, Pizer E, Garcia R, Goff BA. Patterns of spread and recurrence of sex cord-stromal tumors of the ovary. Gynecol Oncol. 2011;122(2):242-5.

Brown J, Sood AK, Deavers MT, Milojevic L, Gershenson DM. Patterns of metastasis in sex cord-stromal tumors of the ovary: can routine staging lymphadenectomy be omitted? Gynecol Oncol. 2009;113(1):86-90.

Sharma P, Jain TK, Parida GK, Karunanithi S, Patel C, Sharma A, et al. Diagnostic accuracy of integrated (18)F-FDG PET/CT for restaging patients with malignant germ cell tumours. Br J Radiol. 2014;87(1040):263.

Nasioudis D, Orfanelli T, Frey MK, Chapman-Davis E, Caputo TA, Witkin SS, et al. Role of adjuvant chemotherapy in the management of non-granulosa cell ovarian sex cord-stromal tumors. J Gynecol Oncol. 2019; 30(2):e19.

Schultz KA, Harris AK, Schneider DT, Young RH, Brown J, Gershenson DM, Dehner LP, Hill DA, Messinger YH, Frazier AL. Ovarian sex cord-stromal tumors. J Oncol Pract. 2016;12(10):940-6.

Schneider DT, Orbach D, Cecchetto G, Stachowicz-Stencel T, Brummel B, Brecht IB, et al. Ovarian sertoli leydig cell tumours in children and adolescents: an analysis of the european cooperative study group on pediatric rare tumors (EXPeRT). Eur J Cancer. 2015;51:543-50.