Pregnancy in a patient with paroxysmal nocturnal hemoglobinuria

Authors

  • Anju Singh Department of Obstetrics and Gynaecology, Post Graduate Institute of Medical Education and Research, Chandigarh, Punjab, India
  • Pooja Sikka Department of Obstetrics and Gynaecology, Post Graduate Institute of Medical Education and Research, Chandigarh, Punjab, India
  • Vanita Suri Department of Obstetrics and Gynaecology, Post Graduate Institute of Medical Education and Research, Chandigarh, Punjab, India
  • Neelam Agrawal Department of Obstetrics and Gynaecology, Post Graduate Institute of Medical Education and Research, Chandigarh, Punjab, India
  • Seema Chopra Department of Obstetrics and Gynaecology, Post Graduate Institute of Medical Education and Research, Chandigarh, Punjab, India
  • Bhupesh Kumar Department of Anesthesia and Intensive Care, Post Graduate Institute of Medical Education and Research, Chandigarh, Punjab, India

Keywords:

Paroxysmal nocturnal hemoglobinuria, Pregnancy, Management

Abstract

The occurrence of Paroxysmal Nocturnal Hemoglobinuria (PNH) during pregnancy is very rare. It can cause significant fetomaternal morbidity and mortality due to associated complement mediated hemolysis and/or thrombosis. We report a case of PNH in a pregnant lady who presented to our antenatal clinic at 10th weeks of gestation. Her pregnancy was managed with multiple blood transfusions and steroid administration.  During 3rd weeks postpartum period she developed sepsis with acute renal failure and posterior reversible encephalopathy syndrome requiring prolonged hospitalization. She was subsequently discharged from hospital in satisfactory condition.

References

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Published

2016-12-24