DOI: http://dx.doi.org/10.18203/2320-1770.ijrcog20202761

An encounter with alobar holoprosencephaly: a case report

Prasanna Venugopalan, Fathima Mithilag, Vidhu V. Nair

Abstract


Alobar holopresencephaly is a rare embryonic condition where there is anomalous fusion of cerebral hemispheres. The key features include neurological impairment and facial dysmorphism like cyclopia, ocular hypertelorism with divided orbits and a proboscis. Obstetric ultrasound and foetal MRI are the diagnostic modalities. Majority of cases are sporadic in origin while a genetic association is also described. A small recurrence risk is noted in cases with sporadic origin. Early diagnosis and pregnancy termination are advisable for the condition since the survival rate is very low.


Keywords


Alobar, Cyclopia, Holoprosencephaly, Proboscis, Recurrence, Sporadic, Termination

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References


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