Prospective study of ovarian function in hysterectomised females

Authors

  • Richa S. Sankhe Department of Obstetrics and Gynecology, Lokmanya Tilak Municipal Medical College, Mumbai, Maharashtra, India
  • Ganesh A. Shinde Department of Obstetrics and Gynecology, Lokmanya Tilak Municipal Medical College, Mumbai, Maharashtra, India

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20203323

Keywords:

Hysterectomy, Follicle stimulating hormone, Pulsatality index

Abstract

Background: Hysterectomy is one of the most common operations performed in the world. The aim of this study was to determine prospectively the influence of hysterectomy on ovarian function by measuring gonadotrophin levels and studying ovarian doppler over a two-year period.

Methods: Authors conducted a prospective cohort study at the department of obstetrics and gynecology in study tertiary care center. The study was carried out over a period of two years November 2012-November 2014. Serum FSH, ovarian PI and questionnaire data were obtained at baseline and at 6 and 12 months postoperatively.

Results: There was significant difference in the mean FSH and mean PI at follow-up visits of 6 and 12 months. Patient characteristics did not contribute to the changes that were observed during the follow-up.

Conclusions: Authors conclude that hysterectomy affects ovarian function by affecting blood supply (reducing blood supply). This is reflected by increased FSH levels and increased PI values on ovarian Doppler.

References

Aloia JF, Cohn SA, Yeh K, Yuen K, Ellis K. Risk factors for postmenopausal osteoporosis. Am J Med. 1985;78:95-100.

Falkeborn M, Schairer C, Naessen T, Persson I. Risk of myocardial infarction after oophorectomy and hysterectomy. J Clin Epidemiol. 2000;53:832-7.

Van der Schouw Y, van der Graa Y, Steyerberg E, Eijkemans M, Banga J. Age at menopause as a risk factor for cardiovascular mortality. Lancet. 1996;347:714-8.

Siddle N, Sarrell P, Whitehead M. The effect of hysterectomy on the age of ovarian failure: identification of a subgroup of women with premature loss of ovarian function and literature review. Fertil Steril. 1987;47:94-100.

Menon RK, Okanofua FE, Agnew JE, Thomas M, Bell J, O'Brien PM, et al. Endocrine and metabolic effects of simple hysterectomy. Int J Gynaecol Obstet. 1987;25:459-63.

Anderson GL, Limacher M, Assaf AR, Bassford T, Beresford SA, Black H, et al. Women's health initiative steering committee. effects of conjugated equine oestrogen in postmenopausal women with hysterectomy: the women's health initiative randomized controlled trial. JAMA. 2004;291:1701-2.

Hulley SB, Grady D. The WHI oestrogen-alone trial-do things look any better? JAMA. 2004;291:1769-71.

Borell U, Fernström I. The adnexal branches of the uterine artery. Acta Radiol. 1953;40:561-82.

Derksen JGM, Brölmann HAM, Wiegerinck MAHM, Vader HL, Heintz APM. The effect of hysterectomy and endometrial ablation on follicle stimulating hormone (FSH) levels up to 1 year after surgery. Maturitas. 1998;29:133-8.

Souza AZ, Fonseca AM, Izzo VM, Clauzet RM, Salvatore CA. Ovarian histology and function after total abdominal hysterectomy. Obstet Gynecol. 1986;68:847-9.

Moorman PG, Myers ER, Schildkraut JM, Iversen ES, Wang F, Warren N. Effect of hysterectomy with ovarian preservation on ovarian function. Obstet Gynecol. 2011;118(6):1271-9.

Downloads

Published

2020-07-23

Issue

Section

Original Research Articles