Assessment of serum lipid profile in early pregnancy and its relation with pre eclampsia: a prospective study
DOI:
https://doi.org/10.18203/2320-1770.ijrcog20160595Keywords:
Preeclampsia, Cholesterol, Triglyceride, Lipid profileAbstract
Background: Pathophysiology of pre eclampsia and atherosclerosis seems to be similar as a hyperlipidemic state, due to hormonal changes in pregnancy. We tried to assess the relationship between maternal plasma lipid concentration and risk of developing pre eclampsia.
Methods: This is a prospective cohort study, for a period of one year from August 2009 to August 2010. Total no of subjects (N=270) were divided into two groups: Control group: who remained normotensive during study and Study group: who developed pre-eclampsia.
Results: The mean level of cholesterol in study group was (226.74±39.77 mg/dl) significantly higher as compared to control group (164±22.48 mg/dl). That was statistically significant (p=0.001). Mean levels of cholesterol in mild PET group was 216±28.90mg/dl and in severe PET group was 252.3±50.63 mg/dl respectively, that was also significantly higher as compared to control group (p=0.001). In our study mean levels of Triglyceride was 153.95±23.52 mg/dl in control group and 205.25±42.48 mg/dl in study group. There were statistically significant difference between the groups (p=0.001). In mild PET mean value of Triglyceride was 198.99±36.12 mg/dl and in severe PET it was 220.35± 53.13mg/dl. It was seen that both the study group had significantly higher mean value as compared to control group (p=0.001).
Conclusions: In present study we have observed that maternal dyslipidemia in early second trimester is associated with increased risk of developing pre eclampsia. So dyslipidemia in early second trimester is a very good predictor of pre eclampsia.
References
Yadav S, Yadav R, Saxena S. Hypertensive disorder of pregnancy and perinatal outcome. The journal of obstetrics and gynaecology of India.1997;47:322-30.
Gupta KB, Radhhvana I, Pal A, Premi HK, Ganeshan J. Perinatal outcome in pregnancy induced hypertension. Journal of the Indian medical association. 1996;94(1):6-16.
Murai JT, MuzYkankiy E,Taylor RN. Maternal and fetal modulator of lipid metabolism correlate with the development of pre eclampsia. Metabolism. 1997;46(8):963-7.
Chesley LC. Vascular reactivity in normal and toxemic pregnancy. Clin obstet gynaecol. 1966;6:871-81.
Vidyabati RK, Davina H, Singh NK, Singh W Gyaneshwar. Serum β hcg and lipid profile in early second trimester as predictor of pregnancy induced hypertension. J obstet gynecol India 2010;60:44-50.
Takahashi WH, Martinelli S, Khoury MA. Assessment of serum lipid in pregnant women aged over 35 years and their relation with pre eclampsia. Einstein. 2008;6(1):63-7.
Auther Baker AM, Klein RL, Haeri S, Boggess K. Maternal serum dyslipidemia occurs early in pregnancy in women with mild but not severe preeclampsia. Am J Obstet Gynecol. 2009;4:201-93.
Enquobahrie D, Williams M,Carole B, Frederick I, Luthy D. Plasma lipid concentration in early pregnancy and risk of pre eclampsia. Am J Obstet Gynecol. 2003;189(6):106.
