A comparative study between ferrous carboxy maltose and iron sucrose in the management of post-partum anaemia in tertiary care hospital
Keywords:Anaemia, Ferrous carboxy maltose, Iron sucrose, Postpartum
Background: Anaemia is a global public health problem contributing tremendously to maternal morbidity and mortality. It is the most common indirect cause of maternal mortality. Variety of injectable iron preparations are now available which can be effective tools for combating post-partum anaemia. This study aims to compare FCM (Ferrous carboxy maltose) and iron sucrose in the treatment of iron deficiency anaemia in post-partum women at KIMS, Hubli, Karnataka, India.
Methods: This study was conducted at KIMS, Hubli in the year 2018-19 wherein 100 post-partum women with hb levels ranging from 5-10g% were selected for the study and randomly allocated into 2 groups- FCM group and iron sucrose group. They were administered 1g of FCM and 1g of iron sucrose respectively after clinical evaluation and baseline measurement of hb. They were followed up after 2 weeks for repeat hb% and review of signs and symptoms. FCM and iron sucrose were compared in terms of their efficacy.
Results: The mean increase in hb% was found to be 3.2 g% in the FCM group and 2 g% in the iron sucrose group. FCM was also found to be more efficacious in providing relief of common signs and symptoms like easy fatigability and pallor compared to iron sucrose.
Conclusions: Ferrous carboxy maltose was found to be more efficacious compared to iron sucrose.
World Health Organization. Haemoglobin concentrations for the diagnosis of anaemia and assessment of severity. Vitamin and Mineral Nutrition Information System. 2011. Available at: http://www.who.int/vmnis/indicators/haemoglobin/en/. Accessed on 14th June 2018.
Lokare PO. A study of prevalence of anemia and sociodemographic factors associated with anemia among pregnant women in Aurangabad city, India. Ann Nig Med. 2012;6(1):30-4.
Froessler B, Collingwood J, Hodyl NA, Dekker G. Intravenous ferric carboxymaltose for anaemia in pregnancy. BMC Preg Childbirth. 2014;14:115.
Bodnar LM, Siega-Riz AM, Miller WC, Cogswell ME, McDonald T. Who should be screened for postpartum anemia? An evaluation of current recommendations. Am J Epidemiol. 2002;156(903-12).
Milman N. Postpartum anemia I: definition, prevalence, causes and consequences. Ann Hematol. 2011;90:1247-53.
Friedrisch JR, Cancado RD. Intravenous ferric carboxymaltose for the treatment of iron deficiency anaemia. Rev Bras Hematol Hemoter. 2015;37(6):400-5.
Gautham KSK. Intravenous iron sucrose. World J Anaemia. 2017;1(1):20-2.
Rudra S, Chandna A, Nath J. Comparison of intravenous iron sucrose with oral iron in pregnant women with iron deficiency anaemia. Int J Reprod Contracept Obstet Gynecol. 2016;5(3):747-51.
Garg R, Nigam A, Agrawal P, Nigam A, Agrawal R. Iron carboxymaltose: a safe and effective molecule to combat anaemia in pregnancy. Int J Curr Res Aca Rev. 2016;4(2):124-30.
Shah S. A comparative study of efficacy and safety of intravenous ferric carboxymaltose versus intravenous iron sucrose in the treatment of iron deficiency anaemia of pregnancy. IOSR J Dent Med Sci. 2018;17(9):13-7.