DOI: http://dx.doi.org/10.18203/2320-1770.ijrcog20195325

The effect of caffeine ingestion in prevention of post-operative ileus after caesarean section: a randomized controlled trial

Amr A. Nadim, Reda M. Ghanem, Madonna G. Benyamine, Fady N. Abdallah, Ahmed M. Abbas

Abstract


Background: Caesarian section (CS) has become more prevalent than the vaginal delivery in Egypt. Many complications could occur after an abdominal surgery. One of the commonest but yet serious complications is the postoperative ileus that can possibly be prevented by caffeine ingestion. The aim of the study is to assess the value of caffeine ingestion in promoting intestinal motility and prevention of postoperative ileus after CS.

Methods: This is a randomized controlled trial that was conducted on 560 cases who were recruited from emergency unit and inpatient wards in Ain Shams University maternity hospital. The patients were divided into two groups where the intervention group received caffeinated coffee while the other group received decaffeinated coffee.

Results: There was statistically significant difference between the two groups regarding the bowel function after CS (p <0.05). The intervention group had improved intestinal functions after the CS. Patients from the intervention group had audible intestinal sound sooner than the control group. In addition, they passed flatus and were able to tolerate food in less time.

Conclusions: Consuming caffeinated coffee after CS contributes significantly to faster restoration of intestinal function. Coffee is a popular drink and can be used to decrease the incidence of postoperative ileus-related complications.


Keywords


Caffeine, Cesarean section, Intestinal motility, Postoperative ileus

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References


Sunil S, Sinha S. Postoperative ileus: a preventable event. Br J Surg. 2000;87:1480‐93.

Teoh WH, Shah MK, Mah CL. A randomised controlled trial on beneficial effects of early feeding post-Caesarean delivery under regional anaesthesia. Singapore Med J. 2007;48(2):152.

Holte K, Kehlet H. Postoperative ileus: progress towards effective management. Drugs. 2002;62(18):2603-15.

Toyomasu Y, Mochiki E, Morita H, Ogawa A, Yanai M, Ohno T, et al. Mosapride citrate improves postoperative ileus of patients with colectomy. J Gastroint Surg. 2011;15(8):1361-7.

Drake TM, Ward AE. Pharmacological management to prevent ileus in major abdominal surgery: a systematic review and meta-analysis. J Gastroint Surg. 2016;20(6):1253-64.

Tan EK, Cornish J, Darzi AW, Tekkis PP. Meta‐analysis: alvimopan vs. placebo in the treatment of post‐operative ileus. Alim Pharmacol Therap. 2007;25(1):47-57.

Beck DE, Sweeney WB, McCarter MD, Ipamorelin 201 Study Group. Prospective, randomized, controlled, proof-of-concept study of the Ghrelin mimetic ipamorelin for the management of postoperative ileus in bowel resection patients. Int J Colorectal Dis. 2014;29(12):1527-34.

Zhuang CL, Ye XZ, Zhang CJ, Dong QT, Chen BC, Yu Z. Early versus traditional postoperative oral feeding in patients undergoing elective colorectal surgery: a meta-analysis of randomized clinical trials. Digest Surg. 2013;30(3):225-32.

Ertas IE, Gungorduk K. Influence of gum chewing on postoperative bowel activity after complete staging surgery for gynecological malignancies: a randomized controlled trial. Gynecol Oncol. 2013;131(1):118-22.

Bragg D, El-Sharkawy AM. Postoperative ileus: Recent developments in pathophysiology and management. Clin Nutr. 2015;34:367-76.

Brown SR, Cann PA, Read NW. Effect of coffee on distal colon function. Gut. 1990;31(4):450-3.

Müller S, Rahbari N, Schneider F, Warschkow R, Simon T, von Frankenberg M. Randomized clinical trial on the effect of coffee on postoperative ileus following elective colectomy. Br J Surg. 2012;99(11):1530-8.

Rabiepoor S, Yas A, Navaei J, Khalkhali HR. Does coffee affect the bowel function after caesarean section?. Eur J Obstet Gynecol Repro Biol. 2018;220:96-9.

Gregory KD, Jackson S, Korst L, Fridman M. Cesarean versus vaginal delivery: whose risks? Whose benefits? Am J Perinatol. 2012;29(1):7-18.

Ratnalikar V, Williams C, Moses T. Perioperative pain management in colorectal surgery. Surg (Oxford). 2017;35(8):426-31.

Sarwar I, Haider S, Khan AB. Effect of early and delayed oral feeding on early ambulation of patients after cesarean section: a randomized controlled trial. J Rehman Med Instit. 2018;2(3).

Gómez-Izquierdo JC, Trainito A, Mirzakandov D, Stein BL, Liberman S, Charlebois P, et al. Goal-directed fluid therapy does not reduce primary postoperative ileus after elective laparoscopic colorectal surgery. A randomized controlled trial. anesthesiology: J Am Soc Anesthesiol. 2017;127(1):36-49.

Zucconi S, Volpato C, Adinolfi F, Gandini E, Gentile E, Loi A, et al. Gathering consumption data on specific consumer groups of energy drinks. EFSA 2013;10:394E.

Dulskas A, Klimovskij M, Vitkauskiene M, Samalavicius NE. Effect of coffee on the length of postoperative ileus after elective laparoscopic left-sided colectomy: a randomized, prospective single-center study. Dis Colon Rectum. 2015;58(11):1064-9.

Akhlaghi F, Pourjavad M, Mansouri A, Tara F, Vahedian M. Effect of gum chewing on prevention of post cesarean ileus. J Hayat. 2008;14(2):35-40.

Amini A, Mortazavi A, Nojoomi M. Assessment of early oral feeding on gastrointestinal symptoms after cesarean delivery and total abdominal hysterectomy. Razi J Med Sci. 2005;11(44):895-900.

Masoudifar M, Aghadavoudi O, Adib S. Effect of venous dexamethasone, oral caffeine and acetaminophen on relative frequency and intensity of postdural puncture headache after spinal anesthesia. Adv Biomed Res. 2016:5

Sechzer PH, Abel L. Post-spinal anaesthesia headache treated with caffeine. PartII. Curr Ther Res. 1979;26:440-8.

Sandesc D, Lupei MI, Sirbu C. Conventional treatment or epidural blood patch for the treatment of different etiologies of post dural puncture headache. Acta Anaesthesiol Belg. 2005;56:265-9.