Study of etiopathogenesis and clinical profile of patients presenting with abnormal uterine bleeding

Authors

  • Namrata Yeole Department of Obstetrics and Gynecology, Lokmanya Tilak Municipal Medical College and General Hospital, Sion, Mumbai, Maharashtra, India
  • Arun H. Nayak Department of Obstetrics and Gynecology, Lokmanya Tilak Municipal Medical College and General Hospital, Sion, Mumbai, Maharashtra, India
  • Madhuri Mehendale Department of Obstetrics and Gynecology, Lokmanya Tilak Municipal Medical College and General Hospital, Sion, Mumbai, Maharashtra, India

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20195999

Keywords:

Abnormal uterine bleeding, Hypothyroidism, Menorrhagia

Abstract

Background: AUB is a common condition affecting 14-25% of women of reproductive age and may have a significant impact on their physical, social, emotional and material quality of life. AUB can occur at any age in various forms and has different modes of presentation. The key to successful clinical management is to recognize or identify the causative factors responsible.

Methods: This study was conducted over 100 patients. Patients with complaints of menstrual irregularity between menarche to premenopausal age group were considered. Data about age, parity, menstrual history, obstetric history, medical history, physical examination, thyroid function test, radiological findings and histopathology were collected and studied.

Results: Incidence of AUB is more common in 5th decade of life. Menorrhagia is the most common bleeding pattern. It is concluded that DUB is the most common cause of AUB. Among the other organic pathological causes, fibroid is the commonest. Maximum number of apparently normal patients with abnormal uterine bleeding belong to category of sub clinical hypothyroid.

Conclusions: Accurate analysis of endometrial sample is the key to effective therapy and rational approach to treatment of women with abnormal uterine bleeding.

References

Dangal G. A study of endometrium of patients with abnormal uterne bleeding at Chitwan valley. Kathmandu Univer Med J. 2003;1:110-2.

Khare A, Bansal R, Sharma S. Morphological spectrum of endometrium in patients presenting with dysfunctional uterine bleeding. People’s J Sci Res. 2012;5(2):13-6.

Livingstone M, Fraser IS. Mechanisms of abnormal uterine bleeding. Human Repro Update. 2002;8(1):60-7.

Munro MG, Critchley HO, Broder MS, Fraser IS. FIGO classification system (PALM‐COEIN) for causes of abnormal uterine bleeding in nongravid women of reproductive age. Int J Obstet Gynaecol. 2011;113(1):3-13.

National Collaborating Center for women’s and Children’s Health, National Institute of Clinical Excellence. Heavy menstrual bleeding. Clinical guideline. London : RCOG Press; 2007.

DeVORE GR, Owens OD, Kase NA. Use of intravenous Premarin in the treatment of dysfunctional uterine bleeding- a double-blind randomized control study. Obstet Gynecol. 1982;59(3):285-91.

Munro MG, Mainor N, Basu R, Brisinger M, Barreda L. Oral medroxyprogesterone acetate and combination oral contraceptives for acute uterine bleeding: a randomized controlled trial. Obstet Gynecol. 2006;108:924-9.

Damle RP, Dravid NV, Suryawanshi KH, Gadre AS, Bagale PS, Ahire N. Clinicopathological spectrum of endometrial changes in peri-menopausal and post-menopausal abnormal uterine bleeding: A 2 years study. J Clin Diagnost Res. 2013;7(12):2774.

Abdullah LS, Bondagji NS. Histopathological pattern of endometrial sampling performed for abnormal uterine bleeding. Bahrain Med Bull. 2011;33(4):1-6.

Jetley S, Rana S, Jairajpuri ZS. Morphological spectrum of endometrial pathology in middle aged women with atypical uterine bleeding - a study of 219 cases. J Midlife Health. 2013;4:216-20.

Jairajpuri ZS, Rana S, Jetley S. Atypical uterine bleeding-Histopathological audit of endometrium A study of 638 cases. Al Ameen J Med Sci. 2013;6(1):21-8.

Pilli GS, Sethi B, Dhaded AV, Mathur PR, Dysfunctional uterine bleeding. J Obstet Gynaecol India. 2001;52(3):87-9.

Patil CS. A study of clinical correlation with histopathological diagnosis of abnormal uterine bleeding MedPulse. Int Med J. 2016;3(7):697-9.

Nargis N, Karim I, Sarwar KB. Abnormal uterine bleeding in perimenopausal age: different causes and its relation with histopathology. Bangl J Med Sci. 2014;13(2):135-9.

Pillai SS. Sonographic and histopathological correlation and evaluation of endometrium in perimenopausal women with abnormal uterine bleeding. Int J Reprod Contracept Obstet Gynecol. 2014;3:113-7.

Mahapatra M, Mishra P. Clinicopathological evaluation of abnormal uterine bleeding. J Health Res Rev. 2015;2(2):45.

Banale M. Clinicopathological spectrum of endometrial changes in abnormal uterine bleeding. Sch J App Med Sci. 2015;3(9A):3168-72.

Salvi A, Mital P, Hooja N, Batar A, Soni P, Beniwal R. Spectrum of endometrial histopathology in women presenting with abnormal uterine bleeding. Parity. 2015;1(2):3.

Agrawal S, Mathur A, Vaishnav K. Histopathological study of endometrium in abnormal uterine bleeding in women of all age groups in western rajasthan (400 cases). Int J Basic Appl Med Sci. 2014;4(3):15-8.

Afghan S, Yasmeen A. Abnormal uterine bleeding (AUB) a clinicopathological study of 150 cases. Ann Pak Inst Med Sci. 2013;9(4):201-4.

Bhavani N, Avanthi S, Aradhana G, Sangeeta C, Prasannakumar VS. A study of correlation between abnormal uterine bleeding and thyroid dysfunction. Int J Recent Trends Sci Tech. 2015;14(1):131-5.

Rani. Study of hypothyroidism in women with abnormal uterine bleeding. J Dent Med Sci 2016;15(4):12-8.

Kaur T, Aseeja V, Sharma S. Thyroid dysfunction in dysfunctional uterine bleeding. Webmed Central Obstet Gynaecol. 2011;2(9):002235.

Pahwa S, Shailja G, Jasmine K. Thyroid dysfunction in dysfunctional uterine bleeding. J Adv Res Bio Sci. 2013;5(1):78-83.

Verma SK, Pal A, Jaswal S. A study of thyroid dysfunction in dysfunctional uterine bleeding. Int J Reprod Contracept Obstet Gynecol. 2017;6:2035-9.

Weeks AD. Correlating menstrual irregularities with levels of thyroid hormone deficiency. BMJ. 2000;320(7235):649.

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Published

2019-12-26

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Original Research Articles