DOI: http://dx.doi.org/10.18203/2320-1770.ijrcog20194390

Gliomatosis peritonei arising in setting of immature teratoma of ovary: a case report

Dhruba Prasad Paul, Kashish Garg, Ashis Kumar Rakshit

Abstract


A 14 years old girl presented to the gynecology OPD with pain abdomen and huge abdominal lump since 2 months. On clinical examination, a large mass of 20x15 cm size was found extended upto the xiphoid process. Serum studies showed rise of CA-125 up to 406.9U/mL and LDH up to 310U/L. USG shows right ovarian cyst of 14.8x14.1x12.8 cm with internal calcification. MRI revealed a well encapsulated mass of 21x19x17cm with solid and cystic mass and upward peritoneal extension. Exploratory laparotomy was performed with right sided salpingo- ophorectomy with infracolic omentectomy, as the omentum appeared granular. She had an uneventful post-operative recovery. Subsequently HPE showed immature teratoma NORRIS grade 3 with co-existent peritoneal gliomatosis (grade 0). She is under regular follow-up and decided to give six cycles of combination chemotherapy with BEP at regional cancer hospital.


Keywords


Abdominal mass, Chemotherapy, Gliomatosis, HPE, Immature teratoma, Laparotomy

Full Text:

PDF

References


Huang HC, Chen CH, Chu CC. Mature cystic teratoma of ovary with gliomatosis peritonei. J Med Sci. 2004;24:343-6.

Menéndez-Sánchez P, Villarejo-Campos P, Padilla-Valverde D. Gliomatosis peritonei: recurrence, treatment and surveillance. Cir Cir. 2011;79:256-9.

Galateanu AG, Terzea DC, Carsote M. Immature ovarian teratoma with unusual gliomatosis. J Ovarian Res. 2013;6:28.

Kraggerud SM, Szymanska J, Abeler VM, Kaern J, Eknaes M, Heim S, et al. DNA copy number changes in malignant ovarian germ cell tumors. Cancer Res. 2000;60:3025-30.

Heifetz SA, Cushing B, Giller R, Shuster JJ, Stolar CJ, Vinocur CD, Hawkins EP. Immature teratomas in children: pathologic considerations: a report from the combined Pediatric Oncology Group/ Children’s Cancer Group. Am J Surg Pathol. 1998;22:1115-24.

Das CJ, Sharma R, Thulkar S. Mature ovarian teratoma with gliomatosis peritonei-A case report. Indian J Cancer. 2005;42:165-7.

Abiko K, Mandai M, Hamanishi J, Matsumura N, Baba T, Horiuchi A, et al. Oct4 expression in immature teratoma of the ovary: relevance to histologic grade and degree of differentiation. Am J Surg Pathol. 2010;34:1842-8.

Pecorelli S, Benedet JL, Creasman WT, Stepherd JH. FIGO staging ofgynecologic cancer. 1994-1997 FIGO Committee on Gynecologic Oncology. International Federation of Gynecology and Obstetrics. Int J Gynaecol Obstet. 1999;65:243-9.

Norris HJ, Zirkin HJ, Benson WL. Immature (malignant) teratoma of theovary. A clinical and pathologic study of 58 cases. Cancer. 1976;37:2359-72.