A comparative study of low dose magnesium sulphate therapy with Pritchard’s regime in management of Eclampsia
Keywords:Eclampsia, Low dose, Magnesium sulphate, Pritchard’s regime
Background: Eclampsia is one of the most common causes of maternal and perinatal mortality and morbidity in India. Amongst the principles of management of eclampsia, the first is the control of convulsions. Magnesium sulphate is the main stay of treatment in eclampsia and imminent eclampsia. Average weight of Indian women is less than the western women due to which lower dose of magnesium sulphate can be used. The aim of the study was to compare the efficacy of low dose magnesium sulphate regimen with standard Pritchard regimen in control of eclampsia.
Methods: The study was carried out at emergency labour room, GMERS Sola Civil Hospital Ahmedabad. 120 patients of eclampsia were divided randomly into study group (n=60) receiving low dose MgSO4 and control group (n=60) receiving Pritchard regimen. The recurrence of convulsion, toxicity of MgSO4 and maternal and fetal outcome was studied.
Results: It was observed that with low dose MgSO4 regime, convulsions were controlled in 91.7% of the cases. With standard Pritchard’s regime convulsions were controlled in 95% of patients. The maternal and perinatal mortality and morbidity were comparable in both groups.
Conclusions: Low dose magnesium sulphate therapy is as effective as Pritchard’s regime for controlling convulsions in eclampsia and can be safely given in Indian women.
Ratnam SS, Rao KB, Kumar SA. Management of PIH. Obstetrics Gynaecology of post graduates. Orient Longman. 2005;1(2):56-67.
Tavana Z, Hosseinmirzaei S. Comparison of maternal serum magnesium level in pre-eclampsia and normal pregnant women. Iran Red Cresc Med J. 2013;15(12):e10394.
Jafrin W, Mia AR, Chakraborty PK, Hoque MR, Paul UK, Shaha KR, et al. An evaluation of serum magnesium status in pre-eclampsia compared to the normal pregnancy. Mymensingh Med J. 2014;23(4):649-53.
Bansal V, Damania KR. Hypertensive disorders in pregnancy, fernando arias, practical guide to high risk pregnancy and delivery 4th Edition. Elsevier. 2015:218-229.
Sardesai S, Maira S, Patil A, Patil U. Low dose magnesium sulphate therapy in eclampsia and imminent eclampsia; regime tailored for Indian Woman. J Obstet Gynecol India. 2003;53(6):546-50.
Witlin AG. Prevention and treatment of eclamptic convulsions. Clin Obstet Gynecol. 1999;42(3):507-18.
Geographic variation in the incidence of hypertension in pregnancy. World health organization international collaborative study of hypertensive disorders of pregnancy. Am J Obstet Gynecol. 1988;158(1):80-3.
Suman S, Patil MS, Patil U. Low dose magnesium sulphate therapy for eclampsia and imminent eclampsia regime tailored for Indian women. Jr Obst Gynaecol India. 2003;53(6):540-6.
Sahu L, Singh S, Tempe A, Koner BC. A randomised comparative study between low dose magnesium sulphate and standard dose regimen for management of eclampsia. Int J Reprod Contracept Obstet Gynecol. 2014;3(1):79-86.
Abdul MA, Nasir UI, Khan N, Yusuf MD. Low dose magnesium sulphate in the control of eclamptic fits, a randomised control trial. Arch Gynecol Obstet. 2013;287:43-6.
Jana N, Dasgupta S, Das AK, Sandra D, Samanta B. Experience of a low dose magnesium sulphate regimen for the management of eclampsia over a decade. Internat J Gyn Obstet. 2013;122(1):13-7.
Begum R, Begum A, Johanson R, Ali MN, Akhter S. A low dose (Dhaka) magnesium sulphate regime for eclampsia. Acta Obstet Gynecol. 2001;80(11):998-1002.