Association of occupational exposure on semen density in male industrial workers undergoing infertility treatment at tertiary care hospital
DOI:
https://doi.org/10.18203/2320-1770.ijrcog20192449Keywords:
Male Infertility, Occupational Hazards, Oligoasthenozoospermia, Semen parametersAbstract
Background: Working with particular substances or under certain working situations may cause some workers to experience abnormalities in their sexual or reproductive health. Occupational exposures can lead to infertility, but the workers may not be aware of such problems. The purpose of the study was to determine the association between male infertility and occupation of industrial workers in organized sector.
Methods: Prospective case-controlled study that included 136 industrial workers working in organized sector and attending infertility clinic for treatment. This study included male partners aged between 21-46 years with primary or secondary infertility and undertaking same occupation for at least last three months. Complete infertility workup of all male partners attending infertility clinic was done that included detailed history and information related to occupation. Routine semen parameters were evaluated according to the 2010 World Health Organization (WHO) criteria.
Results: In the present study, significant semen abnormalities were observed in male partners with age more than 31 years and undertaking arduous jobs for more than 5 years (p <0.05) in study group (n=136) as compared to control group (n=62). The abnormal semen count were observed in 114 (83.2%) workers in the study group that included 43 (31.6%) with total sperm concentration (TSC) less than 10 million/ml and azoospermia in 44 (32.3%). Reduced motility (asthenozoo-spermia) was observed in majority 125 (91.9%) of male partners. The findings were significant (p <0.05) as compared to control group.
Conclusions: Preventive measures in the workplace need to be established to reduce the effect of occupational hazards and its influence in the semen parameters ultimately leading to infertility.
References
Carlsen E, Giwercman A, Keiding N, Skakkebaek NE. Evidence for decreasing quality of semen during past 50 years. BMJ. 1992;305:609-13.
Sharpe RM. Declining sperm counts in men-is there an endocrine cause? J Endocrinol. 1993;136:357-60.
Forti G, Serio M. Male infertility: is its rising incidence due to better methods of detection or an increasing frequency? Hum Reprod. 1993;8:1153-4.
Kumar S. Occupational exposure associated with reproductive dysfunction. J Occup Health. 2004;46(1):1-19.
Sheiner ETK, Sheiner E, Hammel R, Potashnik G, Carel R. Effect of occupational exposures on male fertility: literature review. Ind Health. 2003;41(2):55-62.
Wdowiak A, Wdowiak L, Wiktor H. Evaluation of the effect of using mobile phone on male fertility. Ann Agric Environ Med. 2007:14:169-72.
Celina K, Wdowiak A, Anna BPK. The role of age, environmental and occupational factors on semen density Ann Agric Environ Med 2011: 18:437-40.
Radwan J. Infertility and the assisted reproduction techniques). Wyd Med Termed Wyd Poznań. 2005:33-40.
Schmid TE, Eskenazi B, Baumgartner A, Marchetti F, Young S, Weldon R, et al. The effects of male age on sperm DNA damage in healthy non-smokers. Hum Reprod. 2007;22(1):180-7.
Cherry N, Moore H, McNamee R, Pacey A, Burgess G, Clyma JA, et al. Participating centres of Chaps-UK. Occupation and male infertility: glycol ethers and other exposures. Occup Environ Med. 2008;65(10):708-14.
Sheiner EK, Sheiner E, Carel R, Potashnik G, Vardi I. Potential association between male infertility and occupational psychological stress. J Occup Environ Med. 2002;44(12):1093-9.
Tas S, Lauwerys R, Lisom D. Occupational Hazards of the Male Reproductive System. Crit Rev Toxicol. 1996;26(3):261 – 307
Claman P. Men at risk: occupation and male infertility. Fertil Steril. 2004;81(2):19-26.
Joffe M. Infertility and environmental pollutants. Br Med Bull. 2003;68(1):47-70.
Fleurian G, Perrin J, Ecochard R, Dantony E, Lanteaume A, Achard V, ety al. Occupational exposures obtained by questionnaire in clinical practice and their association with semen quality. J Androl. 2009;30(5):566-79.
Jung A, Schuppe HC. Influence of genital heat stress on semen quality in humans. Androl. 2007;39(6):203-15.
Kovacic P, Jacintho JD. Reproductive toxins: pervasive theme of oxidative stress and electron transfer. Curr Med Chem. 2001;8(7):863-92.
Multigner L, Ben Brik E, Arnaud I, Haguenoer JM, Jouannet P, Auger J, et al. Glycol ethers and semen quality: a cross-sectional study among male workers in the Paris Municipality. Occup Environ Med. 2007;64(7):467-73.
Naha N, Manna B. Mechanism of lead induced effects on human spermatozoa after occupational exposure. Kathmandu Univ Med J. 2007;5(1):85-94.
Oliva A, Spira A, Multigner L. Contribution of environmental factors to the risk of male infertility. Hum Reprod. 2001;16(8):1768-76.
Saradha B, Mathur PP. Effect of environmental contaminants on male reproduction. Environ Toxicol Pharmacol. 2006;21(1):34-41.
Whorton D. Pesticides: pesticide-induced infertility in male workers. occupational safety and health symposia 1978, division of technical services, NIOSH, Cincinnati, Ohio (Contract-210-78-0053). NIOSH. 1979:99-102.
Mieusset R, Bujan L. Testicular heating and its possible contributions to male infertility: a review. Int J Androl. 1995;18:169-84.
Talamanca I, Cini C, Varricchio GC. Effects of prolonged autovehicle driving on male reproduction function: a study among taxi drivers. Am J Industrial Med. 1996;30:750-8.
Thonneau P, Ducot B, Bujan L. Heat exposure as a hazard to male fertility. Lancet. 1996;347:204-5.
Swan SH, Elkin EP, Fenster L. The question of declining sperm density revisited: an analysis of 101 studies published 1934-1996. Environ Health Persp. 2000;108:961-6.
Mieusset R, Bujan L. Testicular heating and its possible contributions to male infertility: a review. Int J Androl. 1995;18:169-84.
Talamanca FI, Cini C, Varricchio GC. Effects of prolonged autovehicle driving on male reproduction function: A study among taxi drivers. Am J Industrial Med. 1996;30:750-8.
Thonneau P, Ducot B, Bujan L. Heat exposure as a hazard to male fertility. Lancet. 1996;347:204-5.
Bujan L, Daudin M, Charlet JP. Increase in scrotal temperature in car drivers. Human Reproduction. 2000;15:1355-7.
Stoy J, Hjollund NH, Mortensen JT. Semen quality and sedentary work position. Int J Androl. 2004;27:5-11.
Sheiner EK, Sheiner E, Hammel R, Potashnik G, Carel R. Effect of occupational exposures on male fertility: literature review. Ind Heal. 2003;41(2):55-62.
