DOI: http://dx.doi.org/10.18203/2320-1770.ijrcog20190280

Efficacy of low dose magnesium sulphate regime and Pritchard’s regime in controlling of eclamptic convulsion and prevention of recurrence

Suryaprakash Jagdevappa Karande, Archana S. Shah

Abstract


Background: Eclampsia is defined as the onset of convulsions or coma during pregnancy or in post-partum period in a patient who has signs and symptoms of pre-eclampsia. It is life threatening emergency that continues to be a major cause of serious maternal morbidity and mortality also along with high perinatal mortality and morbidity. The present study undertaken to determine the efficacy of low dose magnesium sulphate regime and Pritchard’s regime in controlling eclamptic convulsion and prevention of recurrence of convulsion.

Methods: Out of total 60 patients enrolled in the study; 30 were given low dose magnesium sulphate regime and remaining 30 with Pritchard’s regime. Selection of patients was done with simple random sampling. Relevant history was obtained from the patient, if conscious, or from the relatives. Through clinical examination was done and blood samples were collected for investigations after securing IV line.

Results: There was insignificant difference regarding type of eclampsia in both groups. Recurrence of convulsion in Pritchard’s regime group was 6.67% and in Low dose regime group found to be 10% but this was statistically insignificant. Total dose of magnesium sulphate required in Low dose regime group was less than that required for Pritchard’s regime.

Conclusions: Low dose magnesium sulphate Regime proved equally effective as that of Pritchard’s regime in control of convulsion in spite of less amount of drug and comparatively low serum magnesium levels and hence there is hardly any fear of intoxicator.


Keywords


Convulsion, Eclampsia, Low dose magnesium sulphate regime, Pritchard’s regime

Full Text:

PDF

References


Nobis PN, Hajong A. Eclampsia in India through the decades. J Obstet Gynaecol India. 2016;66(Suppl 1):172-6.

Bansal V, Damania KR. Hypertensive disorders in pregnancy, Fernando Arias, practical guide to high risk pregnancy and delivery. 4th ed. Elsevier; 2015:218-229.

Sibai BM. Magnesium sulphate is the ideal anticonvulsant in preeclampsia-eclampsia. Am J Obstet Gynecol. 1990;162:1141-5.

Sardesai SP, Patil A, Maira S, Patil U. Low dose magnesium sulphate therapy for eclampsia and imminent eclampsia: Regime tailored for Indian women. Int J Gynecol Obstet. 2000;70:B45-6.

Pritchard JA, Cunninghan FG, Pritchard SA. The Parkland Memorial Hospital protocol for treatment of eclampsia: Evaluation of 245 cases. Am J Obstet Gynecol. 1984;148:951.

Ranjana, Sinha AR, Prakash C. A comparative study of low dose magnesium sulphate (Dhaka regime) and Pritchard regime for the management of impending eclampsia and eclampsia. Int J Reprod Contracept Obstet Gynecol. 2017;6:2180-5.

Mohanapu S, Raveendran SK, Murugaiah Y, Sen M. A comparative study of low dose magnesium sulphate therapy with standard pritchard’s regime in the management of eclampsia. Int J Reprod Contracept Obstet Gynecol. 2016;5:2939-43.

Charaku S, Rajeshwari J. Comparative study of magnesium sulphate regimens -Pritchard regimen and Dhaka regimen in the management of antepartum eclampsia. Asian Pac J Health Sci. 2016;3(4):220-3.

Begum R. A low dose (Dhaka) Magnesium Sulphate regime for eclampsia. Acta Obstercia Gynecologica Scand. 2001;80(1):998-1002.

Andrea W. Prevention and treatment of eclamptic convulsions. Clinical Obstet Gynecol. 1999;42(3).

Laxmi M, Neha G. Can we improve maternal and foetal outcome in eclampsia by low dose magnesium sulphate?. Asian J Obstet Gynecol Practice. 2011;1:17-20.