Study of serum lipid profile and magnesium in preeclampsia

Authors

  • Hymavathi K. Reddy Department of Obstetrics and Gynecology, Narayana Medical College and Hospital, Nellore, Andhra Pradesh, India
  • Vineela P. Department of Obstetrics and Gynecology, Narayana Medical College and Hospital, Nellore, Andhra Pradesh, India
  • Bhargavi M. Chowdary Department of Obstetrics and Gynecology, Narayana Medical College and Hospital, Nellore, Andhra Pradesh, India

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20191197

Keywords:

High density lipoprotein, Lipid profile, Preeclampsia-serum lipids-magnesium, Serum total cholesterol

Abstract

Background: A comparative study of serum lipid profile and magnesium levels in normal pregnancy versus preeclampsia (PE).

Methods: A prospective study done for 2 years (October 2014 to October 2016) in the Department of Obstetrics and Gynecology, Narayana medical college and hospital, a tertiary care centre, Nellore, Andhra Pradesh, India. A sample size of 200 pregnant women, recruited and divided into group A and B. group A being women with PE and group B is normal pregnant women.A10ml of venous blood was collected in the fasting state and serum collected from clotted blood to measure lipid profile, magnesium, Apo lipoprotein A-I and Apo lipoprotein B 100.Serum Lipid profile  measured by enzymatic method using commercially available kit Human (GmbH Germany) using humastar 600 chemistry analyzer (Human GmbH Germany). Serum magnesium measured by dye binding method using commercially available kit Human (GmbH Germany) using Humastar 600 chemistry analyzer (Human GmbH Germany). Serum ApoA-I and ApoB were measured by immune-turbidometry using commercial kits from Spinreact Spain. Urine albumin done by dipstick method.

Results: Serum total cholesterol (TC), Triglyceride (TG), low density lipoprotein (LDL), very low-density lipoprotein (VLDL), Apo lipoprotein B 100 (Apo B100) were high and serum Magnesium, high density lipoprotein (HDL) and Apo lipoprotein A1(Apo A1) were low in the study group (group A) compared to controls (group B).

Conclusions: Abnormal lipid profile (low HDL and increased TG concentration) and serum hypomagnesaemia may be contributing etiologies of preeclampsia, having good predictive value as a screening procedure for PE in high risk pregnant population.

References

Evrüke IC, Demir SC, Ürünsak IF, Özgünen FT, Kadayıfçı O. Comparison of lipid profiles in normal and hypertensive pregnant women. Annals Saudi Med.2004;24(5):382.

Karar T, Fattah MA, Alenazy KR, Alharbi MJ, Alqahtani FM, Al Tamimi W, et al. Assessment of biochemical changes in pregnancy induced hypertension among Saudi population at KAMC-Riyadh.

Jammalamadaga VS, Abraham P. Abnormal lipid metabolism is associated with angiogenic and anti-angiogenic factor imbalance in PIH women. Int J Reprod Contracept Obstet Gynecol.2017;6(9):3984.

Jain S, Sharma P, Kulshreshtha S, Mohan G, Singh S. The role of calcium magnesium and zinc in preeclampsia. Biol Trace Element Res. 2010;133(2):162-70.

Markrides M, Crowther CA. Magnesium supplementation in pregnancy(review). Cochrane Database syst Rev 2012;10.

Oken E, Ning YI, Rifas-Shiman SL, Rich-Edwards JW, Olsen SF, Gillman MW. Diet during pregnancy and risk of preeclampsia or gestational hypertension. Annals Epidemiol. 2007;17(9):663-8.

Kashinakunti SV, Sunitha H, Gurupadappa K, Shankarprasad DS, Suryaprakash G, Ingin JB. Lipid peroxidation and antioxidant status in preeclampsia. Al Ameen J Med Sci. 2010;3(1):38-41.

Sajith M, Nimbargi V, Modi A, Sumariya R, Pawar A. Incidence of pregnancy induced hypertension and prescription pattern of antihypertensive drugs in pregnancy. Int J Pharma Sci Res. 2014;23:4.

Prakash J, Pandey LK, Singh AK, Kar B. Hypertension in Pregnancy-Hospital Based Study. J Assoc Physic India. 2006;54®:273.

Adegoke OA, lyare EE, Gbenebitse SO. Fasting plasma glucose and cholesterol levels in pregnant Nigerian women. Niger. Postgraduate Med.J.2003;10:32-6.

Jayanta D, Mukhopadhyay A, Pradip KS. Study of serum lipid profile in pregnancy induced hypertension. Ind J of Clin Biochem. 2006;21:165-8.

Islam NA, Chowdhury MA, Kibria GM, Akhter S. Study of serum lipid profile in pre-eclampsia and eclampsia. Faridpur Med College J. 2010;5(2):56-9.

Nazli R, Khan MA, Akhtar T, Lutfullah G, Mohammad NS, Ahmad J, et al. Abnormal lipid levels as a risk factor of eclampsia, study conducted in tertiary care Hospitals of Khyber Pakhtunkhwa Province-Pakistan. Pak J Med Sci. 2013;29(6):1410.

Bardicef M, Bardicef O, Sorokin Y, Altura BM, Altura BT, Cotton DB, et al. Extracellular and intracellular magnesium depletion in pregnancy and gestational diabetes. Am J Obstetr Gynecol.1995;172(3):1009-13.

Standley CA, Whitty JE, Mason BA, Cotton DB. Serum ionized magnesium level in normal and preeclamptic gestation. Obstet Gynaecol. 1997:89:24-31.

Semczuk M, Semczuk-Sikora A. New data on toxic metal intoxication (Cd, Pb, and Hg in particular) and Mg status during pregnancy. Med Sci Monitor. 2001;7(2):332-40.

Bandebuche S, Sagade B, Sontakke A. Serum magnesium in pregnancy induced hypertension. Int J Res Med Sci. 2013;1:413-6.

Patil VP, Choudhari NA. A study of serum magnesium in pre-eclampsia and eclampsia. Indian J Clinic Biochemist. 1991;6(2):69-72.

Indumati V, Kodliwadmath M V, Sheela M K. The role of serum electrolytes in pregnancy induced hypertension. J Clin Diag Res. 2011:5(1):66-9.

Kanagal DV, Rajesh A, Rao K, Devi UH, Shetty H, Kumari S, et al. Levels of serum calcium and magnesium in pre-eclamptic and normal pregnancy: A study from Coastal India. J Clin Diag Res. 2014;8(7):OC01.

Downloads

Published

2019-03-26

Issue

Section

Original Research Articles