Association between the thickness of the collagen in the amniotic membrane with the incidence of premature rupture of membranes

Authors

  • Johny Marpaung Department of Obstetrics and Gynecology, Faculty of Medicine, University of Sumatera Utara, Medan Indonesia

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20160359

Keywords:

Collagen thickness, Amnion thickness, PROM

Abstract

Background: Neonatal Mortality Rate in Indonesia is 19 deaths/1,000 live births and IMR is 32 deaths/1,000 live births which can be associated with the incidence of premature rupture of membranes (PROM). In America, PROM occurs in 2-3% of all pregnancies and 40% associated with preterm birth. Some studies indicate a difference in the thickness of the collagen in the membrane architecture cause structural abnormalities that occur in PROM.

Methods: This study is an observational analytic study with cross sectional study design to see the difference in the thickness of the collagen membrane of the amnion PROM patients with normal pregnant patients conducted in the Department of Obstetrics and Gynecology, Faculty of Medicine USU-General Hospital of Adam Malik, and District Hospital USU on December 2014-March 2015. Sampling was carried out in the delivery room and operating room in General Hospital of Adam Malik. Data analysis was performed by univariate analysis to find the characteristics of the sample and bivariate analysis to compare the thickness of the collagen in amnion membranes at term PROM patients and normal pregnant.

Results: This study showed the thickness of the collagen mother with PROM was 108.11±14.06 mm thinner than the average thickness of the collagen normal pregnant women which was 172.06±38.40 mm. And the thickness of amniotic mother with PROM was 522.72±85.63 mm thinner than the thickness of normal pregnant women amnion was 702.72±180.07 mm.

Conclusions: Statistical test result with t-test. p value <0.05 showed a significant difference collagen thickness and amnion thickness at PROM group with normal pregnant group that showed an association with the PROM and collagen thickness.

References

Entin, Suardi A, Haryani L. Gambaran Hasil Luaran Janin pada Persalianan dengan Ketuban Pecah Dini di RSUP Dr. Hasan Sadikin Bandung Tahun 2009. J Pendid Bidan. 2013. ISSN:2089-2225.

Rangaswamy N, Kumar D, Moore RM, Mercer BM, Mansour JM, Redline R. Weakening and Rupture of Human Fetal Membranes-Biochemistry and Biomechanics. Pre term birth- mother and child. Intech publishers; 2012. DOI: 10.5772/1284, ISBN 978-953-307-828-1.

The American College of Obstetricians and Gynecologists. Premature rupture of membranes. 2013;122(4):918-30.

Intitute of obstetricians and gynaecologists. Preterm prelabour rupture of membranes (PPROM); 2015.

Cut M. Gambaran Histopatologi dan Tampilan Imunohistokimia Fibronektin Selaput Ketuban pada Perempuan Hamil yang Mendapat Acetylsalicylic Acid (ASA). Dosis Rendah, 2014. Available at: http:/repository.usu.ac.id/handle/123456789/41519. Accessed on 25 September 2015.

Putri RE. Perbandingan Ketebalan Selaput Ketuban Pada Ketuban Pecah Dini dan Hamil Normal. Departemen Obstetri dan Ginekologi Fakultas Kedokteran Universitas Sumatera Utara; 2014.

Wilfried B. Mechanical characterization and modeling of human fetal membranes tissue; 2014. DOI:10.3929/ethz-a-010147119.

Ansari H, Singh A, Zaidi MT, Chandra N. Vasculosyncytial membrane in placental villi of normotensive and hypertensive pregnancies. J Anat Soc India. 2011;60(2):168-170.

Chakraborty B, Mandal T, Chakraborty S. Outcome of prelabor rupture of membranes in a tertiary care center in West Bengal. Indian J Clin Pract. 2013;24(7):657-62.

Amstrong-Wells J, Post MD, Donnelly M, Manco-Johnson MJ, Fisher BM, Winn VD. Patterns of placental pathology in preterm premature of membranes. J Dev Orig Helath Dis. 2013;4(3):249-55.

Hasaneroglu, Bakacak M, Suhhabostanci M, Attar R& Han A. Relationship between premature rupture of membranes and collagen amount in amniotic membranes in term pregnancy. Global J Med Res. 2014:2(1):23-5.

Canzoneri BJ, Feng L, Grotegut CA, Bentley RX, Heine RP, Murtha AP. The chorion layer of fetal membranes is prematurely destroyed in women with preterm premature rupture of the membranes. Rep Sci. 2013:20(10):1246-54.

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Published

2016-12-17

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Original Research Articles