Normal obstetric outcome in neurofibromatosis-1 complicating pregnancy

Authors

  • Anitha G.S. Department of Obstetrics & Gynaecology, ESICPGIMS&R, Bangalore, Karnataka, India
  • Manjulatha V.R. Department of Obstetrics & Gynaecology, ESICPGIMS&R, Bangalore, Karnataka, India
  • Kusuma Naik Department of Obstetrics & Gynaecology, ESICPGIMS&R, Bangalore, Karnataka, India

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20151636

Keywords:

Neurofibromatosis, Café au lait spots, Obstetric complication

Abstract

Neurofibromatosis (NF), a genetic disorder, has increased risk of obstetric complications as well as aggravation of maternal disease. However, here is a case of Neurofibromatosis associated with normal obstetric outcome despite the aggravation of dermatological lesions and a history of previous pregnancy with anomalous baby.

References

Oh YM, Koh MS, Yeu JE, Park CS, Cho SJ. A case report of vertebral artery aneurysm and pre eclampsia complicating a pregnancy with neurofibromatosis. Korean J Obstet Gynecol. 2000;43(6):1114-8.

Ruggieri M, Huson SM.The clinical and diagnostic implications of mosaicism in the neurofibromatoses. Neurology. 2001;56:1433–43.

Colman SD, Rasmussen SA, Ho VT, Abernathy CR, Wallace MR. Somatic mosaicism in a patient with neurofibromatosis type 1. Am J Hum Genet.1996; 58:484–90.

Friedman JM. Epidemiology of neurofibromatosis type 1. Am J Med Genet. 1999;(89):1–6.

Huson SM, Hughes RAC, editors. The Neurofibromatoses: Pathogenetic and Clinical Overview, London, Chapman & Hall.1994;160–203.

Weissman A, Jakobi P, Zaidise I, Drugan A. Neurofibromatosis and pregnancy. An update. J Reprod Med. 1993;38(11):890-6.

Dugoff L, Sujansky E. Neurofibromatosis type 1 and pregnancy. Am J Med Genet. 1996;66:7–10.

Leslie KK, White M, Sujanski E. Utilization of polymerase chain reaction (PCR) for identification of estrogen receptors in neurofibromas: potential clinical significance. National Neurofibromatosis Foundation Annual Clinical Care conference. New York: national nf foundation. 1992 case report d rcog 2003. Br J Obstet Gynaecol. 2002;110:530–2.

Todd DN, Wenyu M, Shi C et al. Neurofibromin deficient Schwann cells have increased lysophosphatidic acid dependent survival and migration – implications for increased neurofibroma during pregnancy. Glia .2007;55(5):527-36.

Ansari AH, Nagamani M. Pregnancy and neurofibromatosis (Von Recklinghausen’s disease). Obst & Gynecology. 1976;47(1):25-9.

Terzi YK, Oguzkan-Balci S, Anlar B, Aysun S, Guran S, Ayter S. Reproductive decisions after prenatal diagnosis in neurofibromatosis type 1: importance of genetic counseling. Genet Couns. 2009;20(2):195-202.

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Published

2016-12-16

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Section

Case Reports