Pregnancy in two patients of Glanzmann’s thrombasthenia: a rare case report

Sujata Singh, Sasmita Swain, Lucy Das, R. K. Jena, Om Avishek Das, Balaram Sahoo, Soubhagya Ranjan Subudhi, Kapila Suguna Deepti


Glanzmann’s thrombasthenia (GT) is inherited platelet disorder with an autosomal recessive mode of inheritance. Though, quantitatively normal, the aggregation ability of platelets is reduced in this condition. Pregnancy and delivery are rare in these patients and have been associated with a high risk of severe postpartum hemorrhage. We describe two GT here 1st case was a primigravida, who was diagnosed to have GT 11 yrs back and was admitted as a term pregnancy which was terminated by elective caesarean section and was was successfully managed by platelet transfusion. 2nd case was a 24 year old lady got diagnosed as GT during the evaluation of frequent mucocutaneous bleed. Her antenatal management was like that of normal pregnancy. She was hospitalized 6 weeks prior to expected date of delivery. Elective LSCS (Lower Segment Caesarean Section) was done and was managed with 4 units of single donor platelet (SDP) without any other complication.


Glanzmann's thrombasthenia, Gum bleeding, Pregnancy, Single donor platelet transfusion

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George JN, Caen JP, Nurden AT. Glanzmann's thrombasthenia: the spectrum of clinical disease. Blood.1990;75(7):1383-95.

Sherer DM, Lerner R. Glanzmann's thrombasthenia in pregnancy:a case and review of the literature. Am J Perinatol.1999;16(16):297-301.

Capuzzo E, Polatti F, Zara C. Glanzmann's thrombasthenia and puereperium. Int J Gynecol Obstet. 1997;57:313-4.

Kale A, Bayhan G, YalinKaya A, Yayla M. The use of recombinant factor VIIa in a primigravida with Glanzmann's thrombasthenia during delivery. J Perinat Med. 2004;32(5):456-8.

Malhotra N, Chanana C, Deka D. Pregnancy in a patient of Glanzmann's thrombasthenia. Indian J Med Sci. 2006;60(3):111-3.

Leticee N, Kaplan C, Lemery D. Pregnancy in month with Glanzmann's thrombasthenia and isoantibody against GPIIb-IIIa: Is there a foetal risk? Euro J Obstet Gynecol Reprod Bio. 2005;121:139-42.

Sundqvist SB, Nilsson IM, Svanberg L, Cronberg S. Pregnancy and parturition in a patient with severe Glanzmann’s thrombasthenia. Scand J Haematol. 1981;27:159-64.

Ito K, Yoshida H, Hatoyama H, Matsumoto H, Ban C, et al. Antibody removal therapy used successfully at delivery of a pregnant patient with Glanzmann’s thrombasthenia and multiple antiplatelet antibodies. Vox Sang. 1991;61:40-6.

Kashyap R, Kriplani A, Saxena R, Takkar D, Choudhry VP. Pregnancy in a patient of Glanzmann’s thrombasthenia with antiplatelet antibodies. J Obstet Gynaecol Res. 1997;23:247-50.

Capuzzo E, Polatti F, Zara C. Glanzmann’s thrombasthenia and puerperium. Int J Gynaecol Obstet. 1997;57:313-4.

Sherer DM, Lerner R. Glanzmann’s thrombasthenia in pregnancy: A case and review of the literature. Am J Perinatol. 1999;16:297-301.

Kale A, Bayhan G, Yalinkaya A, Yayla M. The use of recombinant factor VIla in a primigravida with Glanzmann’s thrombasthenia during delivery. J Perinat Med. 2004;32:456-8.

Shamsi TS, Jameel B, Hossain N, Kazi S, Soomro N, Hasan JA, et al. Use of recombinant factor VIIa for massive postpartum haemhorrage: case series and review of literature.J Pak Med Assoc. 2005;55:512-5.