DOI: http://dx.doi.org/10.18203/2320-1770.ijrcog20151600

Is vitamin C able to prevent premature rupture of membranes?

Citra Aryanti

Abstract


Premature rupture of membranes (PROM) is leakage of amniotic fluid through ruptured chorioamniotic membranes that occur before starting the labor pain at any gestational age. This is one of the most common problems in obstetrics with many adverse pregnancy outcomes. Main and final mechanisms of membrane rupture is disturbances in its collagen content metabolism. Vitamin C is found to stabilize the cross link triple helix collagen structure and scavange oxidant that involved in PPROM. Association between vitamin C and PROM remained controversial because studies show variaty results. It is important to know the effective dose of vitamin C because giving large doses of vitamin C can cause adverse reactions.

 


Keywords


Premature rupture of membranes, Amniotic membrane, Vitamin C, Collagen, Doses

Full Text:

PDF

References


Siega A, Promislow J, Savitz D, Thorp J, McDonald T. Vitamin C intake and the risk of preterm delivery.” American journal of obstetrics and gynecology. 2003;189(2):519-25.

Cunningham F, Leveno K, Bloom S, Hauth J, Rouse D, Spong CY. Management of preterm labor. In: Williams obstetrics, 23th ed.; MC Graw Hill, New York, USA. 2010;232-47.

Medina T, Hill D. Preterm premature rupture of membranes: Diagnosis and management. Am Fam. Physician. 2006,73: 659-66.

Mercer B. Premature rupture of the membrane. In: Complicated Pregnancy, 4th ed. Informa health care: London. 2007;713-27.

Goldenberg R, Culhane J, lams J, Romero R. Epidemiology and causes of preterm birth.” Lancet. 371(9606):75-84.

Shen, T, Defranco E, Stamillo D, Chang J, Muglia L. A population based study of race specific risk for preterm premature rupture of membranes. Am J Obstet Gynaecol. 2008;199(4):373.

Gopalani S, Krohn M, Meyn L, Hitti J, Crombleholme W. Contemporary management of preterm premature rupture of membranes: determinants of latency and neonatal outcome. Am J Perinatol. 2004,21(4):183-90.

Osaikhuwuomwan J. Preterm Rupture of membranes: the vitamin C factor. AJOL. 2010;12(1):60-8.

Tejero E, Perichart O, Pfeffer F, Casanueva E, Vadillo-Ortega F. Collagen synthesis during pregnancy, vitamin C availability, and risk of premature rupture of fetal membranes. Int J Gynaecol Obstet. 2003;81(1):29-34.

Niknejad H, Peirovi H, Jorjani M, Ahmadiani A, Ghanavi J, Sefalian M. Properties Of The amniotic membrane for potential use in tissue engineering. European Cells and Materials. 2008;15:88-9.

Iqbal K, Khan A, Khattak M. Biological significance of ascorbic acid (vitamin C) in human health-a review. Pakistan Journal of Nutrition. 2014;3(1):5-13.

Hacisevki A. An Overview of Ascorbic Acid Biochemistry. Ankara Ecz. Fak. Derg. 2009,38(3):233-55.

Duconge J, Miranda-Massari J, Gonzales M, Jackson J, Warnock W, Riordan N. Pharmacokinetics of vitamin C: insights into the oral and intravenous administration of ascorbate. J. Fac. Pharm. 2008,27(1):233-55.

Malak T, Ockleford C, Bell S, Dalgleish R, Bright N, Macvicar J. Confocal immunofluorescence localization of collagen types I, III, IV, V and VI and their ultrastructural organization in term human fetal membranes. Placenta. 1993;14(4):385-406.

Stuart E, Evans G, Lin Y, Powers H. Reduced collagen and ascorbic acid concentrations and increased proteolytic susceptibility with prelabor fetal membrane rupture in women. Biology Reproduction. 2005,72:230-5.

Kanayama N, Terao T, Kawashima T, Horiuchi K, Fujimoto D. Collagen types in normal and prematurely ruptured amniotic membranes. J Obstet Gynaecol. 1985;153:899-903.

Plessinger M, Woods J, Miller R. Pretreatment of human amnion-chorion with Vitamin C and E prevents hypochlorus acid induced damage. Am J Obstet Gynaecol. 2000;183(1):979-85.

Evaldson G, Larsson B, Jiborn H. Is the collagen content reduced when the fetal membranes rupture? A clinical study of term and prematurely ruptured membranes. Gynecol Obstet Invest. 1987;24(2):92-4.

Pfeffer F, Casanueva E, Kamar J, Guerra A, Perichart O, Vadillo-Ortega F. Modulation of 72-kilodalton type IV collagenase (Matrix metalloproteinase-2) by ascorbic acid in cultured human amnion derived cells. Biol Reprod. 1998;59(2):326-9.

Woods JR Jnr. Plessinger MA, Miller RK. Vitamin C and E: Missing links in preventing preterm premature rupture of membranes? Am J Obstet Gynaecol. 2001;185(1):5-10.

Wideman G, Baird G, Bolding O. Ascorbic acid deficiency and premature rupture of fetal membranes. Am J Obstet Gynecol. 1964;88:592-5.

Hadley C, Main D, Gabbe S. Risk factors for preterm premature rupture of the fetal membranes. Am J Perinatol. 1990;7(4):374-9.

Mathews F, Neil A. Antioxidants and preterm prelabour rupture of the membranes. BJOG. 2005;112(5):588-94.

Casanueva E, RipollC, Tolentino M, Morales R, Pfeffer F, Vilchis P. Vitamin C supplementation to prevent premature rupture of the chorioamniotic membranes: a randomized trial. Am J Clin Nutr. 2005,81(4):859-63.

Salminen I, Alfthan G. Plasma ascorbic acid preparation and storage for epidemiological studies using TCA precipitation. Clinical biochemistry. 2008;41:723-7.

Borna S, Borna H, Khazardoost S, Hantoushzadeh S. Perinatal outcome in preterm premature rupture of membranes with Amniotic fluid index < 5 (AFI < 5). BMC Pregnancy Childbirth. 2004;4(1):15.

Hajifoghaha M, Keshavarz T. Vitamin C supplementation and PROM. Iran J Obstet Gynecol Infertil. 2008;11(2):33-9.

Ghomian N, Hafizi L, Takhti Z. The Role of Vitamin C in Prevention of Preterm Premature Rupture of Membranes. Iranian Red Crescent Medical Journal. 2013;15(2):113-6.

Simhan H, Canavan T. Preterm premature rupture of membranes: diagnosis, evaluation and management strategies. BJOG. 2005;112(1):32-7.

Vermillion S, Kooba A, Soper D. Amniotic fluid index values after preterm premature rupture of the membranes and subsequent perinatal infection. Am J Obstet Gynecol 2000, 183(2): 271-276.

Steyn, P., Odendaal, H., Schoeman, J, Stander C, Fanie N. A randomized double-blind placebo-controlled trial of ascorbic acid supplementation for the prevention of preterm labour. J Obstet Gynaecol. 2003;23(2):150-5.

Spinatto J, Freire S, Silva J, Rudge M, Martins-Costa S, Koch M. Antioxidant Supplementation and Premature Rupture of the Membranes: A Planned Secondary Analysis. Am J Obstet Gynecol. 2008;199(4):433.e1-433.e8.