Comparison of efficiency between RMI1 and RMI2 in diagnosing ovarian malignancy

Authors

  • Rashmi R. Shalagar Department of Obstetrics and Gynaecology, Karnataka Institute of Medical Sciences, Hubli, Karnataka, India
  • Narayan Y. Kabadi Department of Surgery, Karnataka Institute of Medical Sciences, Hubli, Karnataka,

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20193508

Keywords:

CA125, Menopausal status, Ovarian malignancy, Risk of malignancy index, Ultrasound score

Abstract

Background: This study was conducted in department of obstetrics and gynaecology, to know the efficiency of risk of malignancy index (RMI) to differentiate a malignant from a benign tumor and to compare the efficiency of risk of malignancy index 1 and 2 (RMI1 and RMI2). The study was conducted from June 2012 to August 2013 in women who got admitted with adnexal tumor.

Methods: It was a prospective study. A proforma was designed for each patient which included, name, age, complaints, menopausal status, parity, past and family history and associated medical condition were asked. Indivisual parameters namely ultrasound score, CA125 and menopausal status and risk of malignancy index was calculated and compared with final histopathological diagnosis and sensitivity specificity and positive predictive value was calculated for each.

Results: : The sensitivity of RMI1 is 87.95%, specificity is 75%, positive predictive value is 94.8%, negative predictive value is 54.54%, percentage of false negative is 12.04% and percentage of false positive is 25%. The sensitivity of RMI2 is 86.74%, specificity is 81.25%, positive predictive value is 96%, negative predictive value is 54.16%, percentage of false negative is 13.25% and percentage of false positive is 18.75%.

Conclusions: The efficiency of RMI was definitely better than indivisual parameters and efficiency of RMI 1 and RMI2 are similar.

References

Jonathan S. Berek: Berek and Novack’s Gynaecology: Lippincott Williams and Wilkins: 15th Edition, Chapter 37: 1350-1416.

Goldstein S. Postmenopausal adnexal cysts: how clinical management has evolved. Am J Obs Gyn. 1996;175(6):1498-501.

Biswas A, Choolani M, Jen J, Low H. Comparison of risk of malignancy indices in evaluating ovarian masses in Southeast Asian population. Singapore Med J. 2013;54(3):136-9.

Anderson ES, Knudsen A, Johansen B. Risk of malignancy index in preoperative evaluation of patients with adnexal masses. Gynecol Onco. 2003;90:109-12.

Petronella AJ, Den V, Akker A, Anette L, Aalders B, et al. Evaluation of risk of malignancy index in daily clinical management of adnexal masses. Gynecol Onco. 2010;116:384-8.

Jacobs I, Oram D, Fairbanks J, Turner J, Frost C, Grudzinskas J. A risk of malignancy index incorporating CA 125, ultrasound and menopausal status for the accurate preoperative diagnosis of ovarian cancer. Int J Obs Gyn. 1990;97(10):922-9.

Tingulstad S, Hagen B, Skjeldestad F, Onsrud M, Kiserud T, Halvorsen T, et al. Evaluation of a risk of malignancy index based on serum CA125, ultrasound findings and menopausal status in the pre operative diagnosis of pelvic masses. Int J Obs Gyn. 1996;103(8):826-31.

Tingulstad S, Hagen B, Skjeldestad F, Halvorsen T, Nustad K, Onsrud M. The risk-of-malignancy index to evaluate potential ovarian cancers in local hospitals. Obstet Gynecol. 1999;93(3):448.

Akturk E, Karaca RE, Alanbay I, Dede M, Karassahin E, et al. Comparison of four malignancy risk indices in the detection of malignant ovarian masses. Gyn Oncol. 2008;22(3):177-82.

Manjunath AP, Kumar P, Sujata, Vani R. Comparison of three risk of malignancy indices in evaluation of pelvic masses. Gynecol Onco. 2001;81:225-9.

Downloads

Published

2019-07-26

Issue

Section

Original Research Articles