Efficacy of combination of tablet mifepristone and misoprostol for first trimester pregnancy termination at different gestational age

Authors

  • Poonam Bhojwani Department of Obstetrics and Gynecology, NIMS Medical College, Jaipur, Rajasthan, India
  • Pragati Meena Department of Obstetrics and Gynecology, NIMS Medical College, Jaipur, Rajasthan, India
  • Gajendra Singh Verma Department of Obstetrics and Gynecology, NIMS Medical College, Jaipur, Rajasthan, India

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20175855

Keywords:

Mifepristone, Misoprostol, Termination of pregnancy

Abstract

Background: Medical method of abortion is a safe, effective and affordable method for first trimester termination. However, nausea, vomiting, diarhoea, excess bleeding and incomplete abortion are known side effects. The aim of study was to compare the success rate of abortions in both groups, to compare the induction-abortion interval in both groups and to study the side effects of the drugs.

Methods: This study was conducted in department of obstetrics and gynecology, NIMS Medical College, Jaipur, India during June 2017-August 2017. Total hundred cases were taken and divided into two groups. Group A was gestational age upto 49 days, Group B was gestational age 50-63 days. Both groups were given tab. mifepristone 200mg. followed by 48 hrs. by 4 tablets of tab misoprostol.

Results: The results of the given regimen were highly successful and complete abortion was achieved in 96% and 94% in group A and group B respectively. The difference between two groups was statistically not significant (p value =0.64). Failure rates were seen in only 4% of group A and 6% of group B. Pain abdomen was seen in 16% of group A and 38% of group B patients. The difference between both groups was statistically significant (p value=0.02). Nausea was seen in 10% of group A and 30% of group B patients. The difference between both groups is statistically significant(p value=0.018).

Conclusions: First trimester pregnancy can be successfully terminated with combination of mifepristone and misoprostol upto 63 days (9 weeks) of pregnancy.

References

Cunningham FG, Leveno KJ, Bloom SL, Haulh JC, Glistrap LC, Wenstrom KD, editors. Abortion. William textbook of obstetrics.

World Health Organization, Department of Reproductive Health and Research. Unsafe abortion: Global and regional estimates of the incidence of unsafe abortion and associated mortality in 2003. 5th ed. Sexual and reproductive health. Available at http://apps.who.int/iris/bitstream/10665/43798/1/9789241596121_eng.pdf

Megh M. FOGSI. comprehensive abortion care and post abortion contraception. FOGSI focus. 2012:15.

Creinin MD, Schwartz JL, Pymar HC, Fink W. Efficacy of mifepristone followed on same day by misoprostol for early termination of pregnancy: report of randomized trial. BJOG. 2001;108:469-73.

International consensus conference on nonsurgical(medical) abortion in early first trimester on issues related to regimens and service delivery. Frequently asked clinical questions about medical abortion. Geneva: World health organization 2006.

Kurtkoti K. FOGSI focus on medical abortion. 2010:5,27,31.

Ellertson C, Waldman SN. The Mifepristone- Misoprostol regimen for early medical abortion. Curr Womens Health Rep. 2001;1:184-190.

Trupin S, Moreno C. Medical abortion: overview and management. Medscape Womens Health. 2001;6:4.

Kulier R, Gulmezoglu AM, Hofmeyer GJ, Chang LN, Campana A. Medical methods for first trimester abortion. Cochrane Database Syst Rev. 2004 Jan 1;2(2).

Mittal S, editor. 2.2.2. 2003. Consortium on National consensus for Medical abortion in India. 2003:122-3. Available at http://www.aiims.edu/aiims/events/gynae-workshop/29-30%20JUNE-2008/Poster.pdf

Coyaji K, Elul B, Krishna U. Mifepristone- Misoprostol abortion: a trial in rural and urban Maharashtra, India. Contraception. 2002;66:33-40.

Deshpande S, Yelikar K, Deshmukh A, Kapil K. Comparative study of medical abortion by mifepristone with vaginal misoprostol in women<49 days versus 50-63 days of amenorhoea. J Obstet Gynecol. 2010;60(5):403-7.

Ashok PW, Penney GC, Flett GM, Templeton A. An effective regimen for early medical abortion: a report of 2000 consecutive case. Hum Reprod. 1998;13(10):2962-5.

Kopp Kallner H, Fiala C, Stephansson O, Gemzell-Danielsson K. Homeself administration of vaginal misoprostol for medical abortion at 50-63 days compared with gestation of below 50 days. Hum Reprod. 2010;25(5):1153-7.

Downloads

Published

2017-12-25

Issue

Section

Original Research Articles