Polyflagellated macrocephalic spermatozoa: failure factor in IVF/ICSI

Authors

  • Fanny Mohamed Department of Gynecology, University and Hospital Center of Yopougon (CHUY), Abidjan, Côte d’Ivoire
  • Dia Jean-Marc Department of Gynecology, University and Hospital Center of Treichville (CHUT), Abidjan, Côte d’Ivoire
  • Adjoussou Stephane Department of Gynecology, University and Hospital Center of Yopougon (CHUY), Abidjan, Côte d’Ivoire
  • Coulibaly Founzegue Institut Pasteur - Felix Houphouet Boigny University, Abidjan, Côte d’Ivoire
  • Fomba Minata Department of Gynecology, University and Hospital Center of Yopougon (CHUY), Abidjan, Côte d’Ivoire
  • Aka Edele Department of Gynecology, University and Hospital Center of Yopougon (CHUY), Abidjan, Côte d’Ivoire
  • Koffi Abdoul Department of Gynecology, University and Hospital Center of Yopougon (CHUY), Abidjan, Côte d’Ivoire
  • Kone Mamourou Department of Gynecology, University and Hospital Center of Yopougon (CHUY), Abidjan, Côte d’Ivoire

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20175040

Keywords:

Macrocephaly, Microinjection, Spermatozoa

Abstract

The authors report two cases of male infertility characterized by spermatic abnormalities of polyflagellated macrocephalic spermatozoa type affecting the entire gametes population. They demonstrate, on the one hand, the technical limitations of microinjection with such spermatozoa due to the large volume of their head and, on the other hand, the unfavourable outcome of the IVF-ICSI with this type of spermatozoa carrying abnormalities constituent. Molecular analysis of the somatic DNA of these subjects revealed a homozygous c.144delC mutation of the Aurora Kinase C gene. Consanguinity at the level of these subjects’ parents appears to be the main risk factor.  This situation constitutes a factor of failure of the IVF and leads to direct the couple towards the donation of gametes or the adoption as solution to the parental project.

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Published

2017-10-28

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Case Reports