DOI: https://dx.doi.org/10.18203/2320-1770.ijrcog20172049
Published: 2017-05-25

Evaluation of maternal serum levels of cell adhesion molecules and endothelial inflammatory markers in normal pregnancy, gestational hypertension and pre-eclampsia

Taru Gupta, Sarika Arora, Anil Kumar, Nupur Gupta, Sangeeta Gupta

Abstract


Background: Hypertensive disorders complicate 5 to 10% of all pregnancies. Despite the still unexplained pathogenesis, endothelial dysfunctions and inflammatory mediators are thought to be responsible for the pathogenesis gestational hypertension and pre-eclampsia. Aims and objective of the study was to determine the serum levels of cell adhesions molecules - VCAM-1 and ICAM-1 and endothelial inflammatory markers TNF-α and homocysteine in normal pregnancies, Gestational Hypertension and in Pre-eclampsia

Methods: The cross-sectional study was carried out in Department of Obstetrics and Gynecology and Biochemistry, ESI-PGIMSR, New Delhi between October 2013-April 2015. 150 patients who gave informed written consent were enrolled and were divided equally in three groups of 50 each (normotensive, gestational hypertensive and pre-eclamptic patients). Three groups have been compared in terms of variables such as age, BMI, gestational age, systolic and diastolic blood pressure, platelet count, AST, ALT, mode of delivery, neonatal weight, VCAM-I, ICAM-I, homocysteine and TNF-alpha concentrations.

Results: We found the higher concentrations of vascular cell adhesions molecules (VCAM-1 and ICAM-1) and inflammatory mediators (homocysteine and TNF α) in gestational hypertensive patients and in pre-eclamptic patients. Out of four markers, concentrations of ICAM-1 was found in largest proportions and it was also statistical significant. P value was <0.001. Though in our study concentration VCAM-1, homocysteine and TNF-α were also high in gestational hypertensive groups as compared with normotensive patients, but they were not statistical significant.

Conclusions: We conclude that higher concentrations of vascular cell adhesions molecules and inflammatory mediators may be responsible for hypertensive disorders of pregnancy suggesting the role of endothelial dysfunction as a central pathogenic feature in development of preeclampsia.


Keywords


Gestational hypertension, Inflammatory mediators (homocysteine and TNF α), Pre-eclampsia, Vascular cell adhesions molecules

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References


Fotis L, Agrogiannis G, Vlachos IS, Pantopoulou A, Margoni A, Kostaki M et al. Intercellular adhesion molecule (ICAM)-1 and vascular cell adhesion molecule (VCAM)-1 at the early stages of atherosclerosis in a rat model. In Vivo. 2012;26(2):243-50.

Guerraty MA, Grant GR, Karanian JW, Chiesa OA, Pritchard WF, Davies PF. Side-specific expression of activated leukocyte adhesion molecule (ALCAM; CD166) in pathosusceptible regions of swine aortic valve endothelium. J Heart Valve Dis. 2011;20(2):165-7.

Costin N, Blaga LD, Ciuchină S, Pop RB. Implication of tumor necrosis factor-alpha in preeclampsia. Appl Med Inform. 2008;23(3, 4):11-8.

Farzadnia M, Ayatollahi H, Sadeghian MH, Meybodi NT. Serum Level of Vascular Cell Adhesion Molecule-1 (sVCAM-1) in Sera. Acta Medica Iranica. 2009;47(1):65-70.

Farzadnia M, Ayatollahi H, Hasan-zade M, Rahimi HR. A comparative study of serum level of vascular cell adhesion molecule-1 (sVCAM-1), intercellular adhesion molecule-1 (ICAM-1) and high sensitive C-reactive protein (hs-CRP) in normal and pre-eclamptic pregnancies. Iran J Basic Med Sci. 2013;16(5):689-93.

Patel AP, Chakrabarti C, Singh A, Patel JD, Mewada HA, Sharma SL. Effect of homocysteine, vitamin b12, folic acid during pregnancy. NHL J Med Sci. 2012;1:27-31.

Khosrowbeygi A, Ahmadvand H. Circulating levels of homocysteine in preeclamptic women. Bangladesh Med Res Counc Bull. 2011;37:106-9.

Laskowska M, Oleszczuk J. Homocysteine in pregnancies complicated by preeclampsia with and without IUGR: a comparison with normotensive pregnant women with isolated IUGR and healthy pregnant women. Open J Obstet Gynecol. 2011;1:191-6.

Marusic J, Prusac IK, Tomas SZ, Karara JR, Roje D. Expression of inflammatory cytokines in placentas from pregnancies complicated with preeclampsia and HELLP syndrome. J Maternal-Fetal Neonat Med. 2013;26(7).

Sharma A, Satyam A, Sharma JB. Leptin, IL-10 and inflammatory markers (TNF-alpha, IL-6 and IL-8) in pre-eclamptic, normotensive pregnant and healthy non-pregnant women. Am J Reprod Immunol. 2007;58(1):21-30.

Vahid Roudsari F, Ayati S, Ayatollahi H, Esmaeily H, Hasanzadeh M, Shahabian M et al. Comparison of maternal serum tumor necrosis factor–alpha(TNF-α) in severe and mild preeclampsia versus normal pregnancy. Iranian J Reprod BioMedicine. 2009;7(4):153-6.