DOI: http://dx.doi.org/10.18203/2320-1770.ijrcog20172344

A study on HPV mRNA test and colposcopy in HIV positive women for early detection of cervical intraepithelial lesions

Kavita N. Singh, Sheetal Achale, Vineeta Ghanghoriya

Abstract


Background: Sexually transmitted infections (STIs) have a profound impact on sexual and reproductive health worldwide. At any point of time, globally more than 290 million women suffer from HPV infection, one of the most common STIs. There are only few studies from India reported regarding the prevalence of HPV and cervical abnormalities among HIV-positive women. This study was carried out to estimate the prevalence of HPV and other genital tract infection in HIV positive women and correlate HPV mRNA test and colposcopic findings with cyto-histopathology in HIV positive women who are not on antiretroviral therapy (ART). Secondary objective was to benefit HIV positive women by making them aware about the importance of screening, early detection and treatment of various lower genital tract infections, CIN and cancer cervix.

Methods: cross sectional observational study was conducted in department of Obstetrics and Gynecology, NSCB medical college Jabalpur (M.P.) from March 2015 to August 2016 on 70 HIV positive women in whom anti-retroviral therapy was not started. This study was approved by institutional ethical committee. The data was recorded in predesign coded case report form and statistical analysis was performed using the STATA 12.1.

Results: In the present study, prevalence of lower genital tract infections in HIV positive women not on ART was 30.0% and the prevalence of high risk HPV was 5.9%.

Conclusions: The study concludes that diagnostic efficacy of HPV mRNA test has similar diagnostic value as that of histopathology report.


Keywords


CIN, Colposcopy, HIV, High risk HPV, HPV mRNA

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References


Sanjose S, Diaz M, Castellsague X, Clifford G, Bruni L, Munoz N, et al. Worldwide prevalence and genotype distribution of cervical human papillomavirus DNA in women with normal cytology: a meta-analysis. Lancet Infect Dis. 2007;7(7):453-9.

New Delhi: Department of AIDS Control, National AIDS Control Organization, Ministry of Health and Family Welfare, Government of India; 2014. Annual Report; 2013-14.

Bruni L, Barrionuevo-Rosas L, Albero G, Aldea M, Serrano B, Valencia S, et al. ICO Information Centre on HPV and Cancer (HPV Information Centre). Human papillomavirus and related diseases in India Summary report; 2015-12-23.

Sarkar K, Pal R, Bal B, Saha B, Bhattacharya S, Sengupta S, et al. Oncogenic HPV among HIV infected female population in West Bengal, India. BMC Infect Dis. 2011;11:72.

Aggarwal R, Sachdeva RK, Naru J, Suri V, Sharma A, Nijhawan R. HPV genotyping in north Indian women infected with HIV. Int J Gynecol Pathol. 2012;31:475-81.

Badkur P, Singh KN, Ghanghoriya V. Colposcopic study of lower genital tract infections in HIV positive women on antiretroviral therapy. J Obstetgynecol India. 2016;66:471-7.

Sellors JW, Sankaranarayanan R. Colposcopy and treatment of cervical intraepithelial neoplasia. Geneva: WHO; 2003;2003 Sep 20.

Bornstein J, Bentley J, Bösze P, Girardi F, Haefner H, Menton M, et al. 2011 colposcopic terminology of the International Federation for Cervical Pathology and Colposcopy. Obst Gynecol. 2012;120(1):166-72.

Singh KN, Chakma T, Verma S. Colposcopic assessment of the cervix using the simplified Reid"s Colposcopic Index method. Current Science. 2009; 96(3):386-91.

Goel V, Bhalla P, Sharma A, Mala YM. Lower genital tract infections in HIV-seropositive women in India.Indian Journal of Sexually Transmitted Diseases and AIDS. 2011;32(2):103.

Harris TG, Burk RD, Palefsky JM. Incidence of cervical squamous intraepithelial lesions associated with HIV serostatus, CD4 cell counts, and human papillomavirus test results. JAMA. 2005;293(12):1471-6.

Rugpao S, Srisomboon J, Chaiyarassamee O, Nelson KE, Nagachinta T, Suriyanon V, et al. Gynaecological conditions associated with HIV infection in women who are partners of HIV-positive Thai blood donors. Internat J STD AIDS. 19981;9(11):677-82.

Sørbye SW, Fismen S, Gutteberg TJ, Mortensen ES, Skjeldestad FE. Primary cervical cancer screening with an HPV mRNA test: a prospective cohort study. BMJ open. 2016;6(8):e011981.