Prevalence of hyperprolactinemia in infertile cases and its correlation with TSH in a rural set up hospital

Authors

  • Madhuprita Agrawal Department of Obstetrics and Gynaecology, Acharya Vinoba Bhave Rural Hospital, Wardha, Maharashtra, India
  • S. Samal Department of Obstetrics and Gynaecology, Acharya Vinoba Bhave Rural Hospital, Wardha, Maharashtra, India
  • C. Hariharan Department of Obstetrics and Gynaecology, Acharya Vinoba Bhave Rural Hospital, Wardha, Maharashtra, India
  • Sweta Agrawal Department of Obstetrics and Gynaecology, Acharya Vinoba Bhave Rural Hospital, Wardha, Maharashtra, India

Keywords:

Hyperprolactinemia, Infertility, Prolactin, Hypothyroidism

Abstract

Background: Hyperprolactinemia is a common endocrine disorder of hypothalamic-pituitary ovarian axis affecting the reproductive functions. Despite the significant role of hyperprolactinemia in infertility, serum prolactin estimation is still not universally done as a part of evaluation of infertility. This study intended to find out the incidence of hyperprolactinemia in infertility, highlight the importance of assessment of serum TSH level in hyperprolactinemia.

Methods: 200 cases of primary and secondary infertility were investigated for serum prolactin levels at Acharya Vinoba Bhave Rural Hospital, Wardha from 2011-2013.

Results: There were 130 (65%) cases of primary infertility as against 70 (35%) cases of secondary infertility. A maximum of 106 (53%) cases were in the age group of 26 - 30 years, with the mean age as 27.50±3.76years. There were 11.5% cases of hyperprolactinemia out of 200 cases of infertility. 21.73% cases of hyperprolactinemia had hypothyroidism.

Conclusion: The high prevalence of hyperprolactinemia with infertility stresses the fact that all the cases of infertility should be subjected for serum prolactin estimation. Prolactin estimation should be done at early stages of infertility check up rather than straight away going for more costly tests or invasive procedures. There is high crude prevalence of hypothyroidism in hyperprolactinemia. All the cases of hyperprolactinemia should have TSH estimation.

 

References

Poppe K, Velkeniers B. Thyroid and infertility. Verh K Acad Geneeskd Belg. 2002;64(6):389-99.

World Health Organization. Infecundity, infertility, and childlessness in developing countries. DHS Comparative Reports No 9. Calverton, Maryland, USA: ORC Macro and the World Health Organization; 2004.

N. Akhter & S.A. Hassan: Sub-clinical hypothyroidism and hyperprolactinemia in infertile women: Bangaladesh perspective after universal salt iodination. The Internet Journal of Endocrinology. 2009;5.DOI 10.5580/8a.

Prabhakar VK, Davis JR. Hyperprolactinemia. Best Pract Res Clin Obstet Gynaecol.2008 Apr;22(2): 341-53.

Biller BM, Luciano A. et al. Guidelines for the diagnosis and treatment of hyperprolactinemia. J Rep Med. 1999; 44(suppl):12.

Hollowell JG, Staehling NW, Flanders WD, et al. Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III). J Clin Endocrinol Metab 2002; 87: 489-99

Cooper DS, Halpern R, Wood LC, Levin AA, Ridgway EC.L-Thyroxine therapy in subclinical hypothyroidism. A double-blind, placebo-controlled trial. Ann Intern Med 1984; 101:18-24.

Goswami B, Patel S, Chatterjee M , Koner BC, Saxena A. Correlation of Prolactin and Thyroid Hormone Concentration with Menstrual Patterns in Infertile Women. J Reprod Infertil. 2009;10(3):207-212.

Ikechebelu JI, Adinma JI,Orie EF, Ikegwuonu SOJ Obstet Gynaecol. High prevalence of male infertility in southeastern Nigeria. J Obstet Gynaecol.2003 Nov;23(6):657-9.

Avasthi Kumkum, Kaur Jasmine , Gupta Shweta et al. Hyperprolactinema and its correlation with hypothyroidism in infertile women. J Obstet Gynecol India. 2006 ;56: 68-71.

Sharma N, Baliarsingh S, Kaushik GG. Biochemical association of hyperprolactinemia with hypothyroidism in infertile women. Clin Lab. 2012; 58(7-8):805-10.

Inhorn MC. Global infertility and the globalization of new reproductive technologies: illustrations from Egypt. Soc Sci Med 2003; 56 : 1837-51.

Singh VK and Vishnol K. A study of uterine and serum prolactin in cases of female infertility of unknown aetiology. J Obstet Gynecol India. 1981; 31: 788 - 793.

Ban Mousa Rashid, Tayfoor Jalil Mahmoud et al . Hormonal Study of Primary Infertile Women. Journal of Zankoy Sulaimani- Part A (JZS-A). 2013;15 (2):137-142

Cheung AP et al. Advance reproductive age and fertility. J Obstet Gynaecol Can. 2011;33(11):1165-75.

Verma I, Sood R, Juneja S, Kaur S. Prevalence of hypothyroidism in infertile women and evaluation of response of treatment for hypothyroidism on infertility. Int J App Basic Med Res .2012;2:17-9.

Thirunavakkarasu K, Dutta P, et al. Macroprolactinemia in hyperprolactinemic infertile women. Endocrine. 2013 Mar 30.

Olooto, Wasiu Eniola; Adeleye et al. Pattern of Reproductive Hormones (Follicle Stimulating Hormone, Luteinizing Hormone, Estradiol, Progesterone, and Prolactin) Levels in Infertile Women in Sagamu South Western Nigeria. Der Pharmacia Lettre. 2012;4(2):549-553.

Pratibha D, Govardhani M, Krihna PT. Prolactin levels in infertility and Bromocriptine therapy in hyperprolactinemia. J Indian Med Assoc 1994; 92(12):397-399.

N Sonino, C Navarrini, et al. Life events in the pathogenesis of hyperprolactinemia. European journal of Endocrinology. 2004;151: 61-65.

Verhelst J, Abs R. Hyperprolactinemia: pathophysiology and management. Treat Endocrinol. 2003;2(1):23-32.

Schlechte JA. Long-term management of prolactinomas. J Clin Endocrinol Metab. Aug 2007;92(8):2861-5.

Topalski-Fistes N, Bujas M, et al. Hyperprolactinemia and disorders of the menstrual cycle. Med Pregl. 1999 Mar-May;52(3-5):156-61.

Emokpae MA, Osadolor HB, Omole Ohonsi A. Sub-clinical hypothyroidism in infertile Nigerian women with hyperprolactinaemia. Niger J Physiol Sci. 2011 Nov 23;26(1):35-8.

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Published

2016-12-13

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Original Research Articles