Role of cytology, colposcopy and biopsy in the detection of cervical intraepithelial neoplasia

Authors

  • Pooja H. Khakhla Department of Obstetrics and Gynaecology, S.B.K.S. Medical Institute and Research Centre,Dhiraj General Hospital, Sumandeep Vidyapeeth, Pipariya, Vadodara, Gujarat, India
  • R. Anand Department of Obstetrics and Gynaecology, S.B.K.S. Medical Institute and Research Centre,Dhiraj General Hospital, Sumandeep Vidyapeeth, Pipariya, Vadodara, Gujarat, India
  • Jyoti G. Sharma Department of Obstetrics and Gynaecology, S.B.K.S. Medical Institute and Research Centre,Dhiraj General Hospital, Sumandeep Vidyapeeth, Pipariya, Vadodara, Gujarat, India
  • Bhargav B. Boghara Department of Obstetrics and Gynaecology, S.B.K.S. Medical Institute and Research Centre,Dhiraj General Hospital, Sumandeep Vidyapeeth, Pipariya, Vadodara, Gujarat, India

Keywords:

Cytology, Colposcopy, Biopsy, Cervical Intraepithelial Neoplasia

Abstract

Background: Cervical cancer is both preventable and curable. It has a long natural history with a prolonged pre-cancerous phase that is easily detectable and treatable. Exfoliative cervical cytology remains the mainstay for screening of pre-cancerous lesions (cervical intraepithelial neoplasia, CIN). In this study we discuss role of cytology, colposcopy and biopsy in the detection of cervical intraepithelial neoplasia.

Methods:  This is a prospective observational study done at the Department of Obstetrics and Gynecology, Dhiraj General Hospital from April 2013 for a period of 4 months. Total of 200 eligible women were enrolled for the study.

Results:Colposcopy was well-correlated with histology in 69.70% cases.Cytology was well-correlated with histology in 65.15% of cases & with majordiscrepancy in 18.18% cases.

Conclusion:The incidence of cervical cancer will continue to be very high in our population because of the constant high incidence of early marriage, multiparity, poor nutrition, poor hygiene, and low living standards. Thus there is a need for screening of these patients for cervical cancer and till date exfoliative Cytology has been found to be the Gold Standard for detection of early malignancy. Universal cytologic screening of all sexually active women should be done, especially in cases of parous women in lower socio-economic groups. Treatment & follow-up of dysplasia could prevent malignancies in future.

References

Seung Jo Kim. Role of Colposcopy and cervicography in screening and management of pre-cancerous lesions and early invasive cancer of uterine cervix. J Obstet Gynecol India. 2000 Oct;50(5):139-146.

Richard RM. Natural history of cervical intraepithelial neoplasia. Clin Obstet Gynecol 1968;10:748-84.

Fahey MT, Irwig L, Macaskill P. Meta-analysis of Pap test accuracy. Am J Epidemiol. 1995 Apr 1;141(7):680-9.

Arora R. Cervical Cancer: a clinical approach. Obs and Gyane Today, 1999 Nov;4(11):658-666.

Donohue LR, Meriwether W. Colposcopy as a diagnostic tool in the investigation of cervical neoplasias. Am J Obstet Gynecol. 1972 May 1;113(1):107-10.

Miller A: Screening for cervical cancer, in Rubin SC, Hoskins, WJ (eds):Cervical Cancer and Preinvasive Neoplasia. Philadelphia, Pa., Lippincott-Raven, 1996, pp 13-25.

Saraiya UB.Screening for cervical cancer. FOGSI Focus 1993 May;3.

Crisp WE, Craine BL, Craine EA. The computerized digital imaging colposcope: future directions. Am J Obstet Gynecol. 1990 Jun;162(6):1491-7; discussion 1497-8.

Downloads

Published

2016-12-13

Issue

Section

Original Research Articles