Study of vitamin D deficiency and supplementation in pre-eclamptic toxemia & its feto-maternal outcome
Keywords:Pre-eclampsia, Caesarian-section, Eclampsia
Background: The present study has been conducted to study the prevalence of vitamin D deficiency and evaluate the efficacy of vitamin D supplementation over pre-eclamptic women & its maternal and neonatal outcome.
Methods: The present study was conducted on 280 pre-eclamptic women. In 2nd & 3rd trimester attending outpatient department at Upper India Sugar Exchange Maternity Hospital, Department of Obstetrics and Gynecology G.S.V.M. Medical college, Kanpur, during the period of January 2013 to July 2014.Vit D measured on first visit and supplementation of vitamin D 2000 IU per day accordingly .Patients were followed till delivery for antinatal and neonatal outcome.
Results: Vitamin D supplementation had significant reduction in incidence of severe preeclampsia. Vitamin D supplementation had significant 1.4 times reduction in incidence of caesarian section (OR=3.659, 95% CI=1.3668 to 9.9745, P=0.01). Only 7.141% who received Vitamin D supplementation had new born with birth weight >2.5 kg in comparison to 26.67% pregnant women who did not received Vitamin D supplementation (OR=4.8431, 95% CI=1.6928-13.8561, P=0.0033).
Conclusions: Vitamin D supplementation is significantly associated with better maternal and neonatal outcome.
Redman CW, Sacks GP, Sargent IL. Preeclampsia: an excessive maternal inflammatory response to pregnancy. Am J Obstet Gynecol. 1999;180:499-506.
Grant WB. Role of vitamin D in up-regulating VEGF and reducing the risk of pre-eclampsia. Clin Sci (Lond). 2009;116(12):871.
Bodnar LM, Klebanoff MA, Gernand AD, Platt RW, Parks WT, Catov JM, et al. Maternal vitamin D status and spontaneous preterm birth by placental histology in the US Collaborative Perinatal Project. Am J Epidemiol. 2014;179:168-76.
Merewood A, Mehta SD, Chen TC, Bauchner H, Holick MF. Association between vitamin D deficiency and primary cesarean section. J ClinEndo crinol Metab. 2009;94(3):940-5.
Rochat MK, Ege MJ, Plabst D, Steinle J, Bitter S, Braun-Fahrl C, et al. Maternal vitamin D intake during pregnancy increases gene expression of ILT3 and ILT4 in cord blood. Clinical & Experimental Allergy. 2010;40:786-94.
Scholl TO, Chen X. Vitamin D intake during pregnancy:association with maternal characteristics and infant birth weight. Early Hum Dev. 200985(4):231-4.
Sabour H, Hossein-Nezhad A, Maghbooli Z,Madani F, Mir E, Larijani B. Relationship between pregnancy outcomes and maternal vitamin D and calcium intake:A cross-sectional study. Gynecol Endocrinol. 2006;22;585-9.