Juvenile granulosa cell tumour: a rare clinical entity

Kaliki Hymavathi Reddy, Pavithra D, Ragini R, Pallavi S


Ovarian cancer is the third most common neoplasm of the female genital tract. Based on the cell type of origin, primary ovarian malignancies are classified into surface epithelium, germ cell, and sex cord tumors. Sex cord tumors account for 1% to 2% of ovarian malignancies. They may contain granulosa cells, theca cells, sertoli cells, or fibroblasts of gonadal stromal origin. Granulosa Cell Tumours (GCTs) account for approximately 2-5% of all ovarian tumors and can be divided into adult (95%) and juvenile (5%) types based on histologic findings. GCTs secrete estrogen thus resulting in menstrual irregularities in the affected individual. More serious estrogen effects can occur in various end organs such as uterus resulting in endometrial hyperplasia, endometrial adenocarcinomas and increased risk of breast cancers. Androgen production is also reported but rare and produces virilization in the affected women. Juvenile Granulosa Cell Tumours (JGCTs) are clinically & histopathologically distinct from the GCTs. They are rarely encountered but mostly in youngsters. Surgery is the primary modality of treatment with chemotherapy being reserved for advanced or recurrent disease states. We herewith report an interesting case of JGCT in a young teenage girl.  


Ovarian sex cord stromal tumours, Juvenile granulosa cell tumour

Full Text:



Divya Khosla, Kislay Dimri, Romeeta Trehan. Ovarian granulosa cell tumor: clinical features, treatment, outcome & prognostic factors. N Am J Med Sci. 2014 Mar;6(3):134-8.

Sakina Sekkate, Mouna Kairouani, Badr Serji, Adnane Tazi, Hind Mrabti, Saber Boutayeb, et al. Ovarian granulosa cell tumors: a retrospective study of 27 cases and a review of the literature. World J Surg Oncol. 2013;11:142.

Mava Y, Chinda JY, Alhaji MA, Nggada HA. Childhood ovarian juvenile granulosa cell tumour: a case report and review of literature. Niger J Paediatr. 2012:39(4):199-201.

Adachi T, Sato H, Nakayama S, Shimizu S, Matsui H, Nakabayashi M. Primary amenorrhea due to juvenile granulosacell tumor of the ovary: a case report. J Obstet Gynaecol Res. 2012;38(3):597-6.

Nisha Nigil Haroon, Gaurav Agarwal, Rakesh Pandey, Preeti Dabadghao. Juvenile granulosa cell tumor presenting as isosexual precocious puberty: A case report and review of literature. Indian J Endocrinol Metab. 2013 Jan-Feb;17(1):157-9.

Nomelini RS, Micheletti AM, Adad SJ, Murta EF. Androgenic juvenile granulosa cell tumor of the ovary with cystic presentation: a case report. Eur J Gynaecol Oncol. 2007;28(3):236-8.

Colombo, Parma G, Zanagnolo V, Insinga A. Management of ovarian stromal cell tumors. J Clin Oncol. 2007;25(20):2944-51.

Kristin RR, William M. An unusual case of juvenile granulose cell tumour of the ovary. Radiol Case Rep. 2009;4:178.

Pectasides D, Pectasides E, Psyrri A. Granulosa cell tumor of the ovary. Cancer Treat Rev. 2008 Feb;34(1):1-12.

Brown J, Shvartsman HS, Deavers MT, Ramondetta LM, Burke TW, Munsell MF, et al. The activity of taxanes compared with bleomycin, etoposide, and cisplatin in the treatment of sex cord-stromal ovarian tumors. Gynaecol Oncol. 2005;97(2):489-96.