Congenital anomalies: the spectrum of distribution and associated maternal risk factors in a tertiary teaching hospital

Authors

  • Vinitha Wills Department of Obstetrics and Gynecology, Pushpagiri Medical College, Thiruvalla, Kerala, India
  • Jacob Abraham Department of Paediatrics, Pushpagiri Medical College, Thiruvalla, Kerala, India
  • N. S. Sreedevi Department of Obstetrics and Gynecology, Pushpagiri Medical College, Thiruvalla, Kerala, India

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20171427

Keywords:

Congenital anomalies, Risk factors

Abstract

Background: To study the system-wise occurrence of congenital anomalies in newborns admitted in a tertiary hospital and to study the associated maternal factors.

Methods: This is a retrospective study of all the mothers and their newborn babies with congenital anomalies who were delivered or referred to the Obstetrical Department / Neonatology unit during a two-year study period. The maternal risk factors and associated Obstetric complications were studied.

Results: Among the babies born with congenital anomalies, the systems most involved were Genito-urinary System (28.5%) and Cardiovascular System (20.5%). Among the maternal risk factors, Diabetes (14.01%), previous abortions (12.7%) and hypothyroidism (8.7%) were the most significant associated factors. Intrauterine growth restriction (17.4%) was noted to be more common in these babies.

Conclusions: The incidence of anomalies was most involving the Genito-urinary System and Cardiovascular System. The major risk factor identified was maternal Diabetes. Prevention by public awareness during adolescence, pre-conceptional counseling and antenatal screening is stressed. Availability of Pediatric surgery and Rehabilitative facilities to improve the quality of life would be warranted.

References

Sarkar S, Patra C, Dasgupta MK, Nayek K, Karmakar PK. Prevalence of Congenital Anomalies in Neonates and Associated Risk Factors in a tertiary care hospital in Eastern India. J Clin Neonatol. 2013; 2(3):131-4.

Park K. Preventive medicine in Obstetrics, Pediatrics and Geriatrics. In: Park’s Textbook of Preventive and Social Medicine.: Banarsidas Bhanot Publishers. 23rd Edition.2015;577.

Slavotinev A. Dysmorphology. In: Kliegman, Stanton, St, editors. Nelson Textbook of Pediatrics. Vol I. 1st South Asia Edition. Elsevier;899-909.

Mashuda F, Zuechner A, Chalya PL, Kidenya BR, Manyama M. Pattern and factors associated with congenital anomalies among young infants admitted at the Bugando Medical Centre, Mwanza, Tanzania. BMC Research Notes. 2014 7:195.

Howson CP, Christianson AC, Modell B. Controlling birth defects: reducing the hidden toll of dying and disabled children in low-income countries. Dis Control Prior Proj. 2008.

Singh A, Gupta RK. Pattern of congenital anomalies in newborn: a hospital based prospective study. JK Sci. 2009,1:34-6.

Sekhobo JP, Druschel CM. An evaluation of congenital malformations surveillance in New York State: an application of Centres for Disease Control and Prevention (CDC) guidelines for evaluating surveillance systems. Public Health Rep. 2001. 116:296-305.

Birch MR, Grayson N, Sullivan EA. AIHW Cat. No. PER 23. Birth Anomalies Series No. 1. Sydney: AIHW National Perinatal Statistics Unit. Recommendations for development of a new Australian birth anomalies system: A review of the congenital malformations and birth defects data collection. 2004.

Biri A, Onan A, Korucuoglu Ü, Tiras B. Birth prevalence and distribution of congenital anomalies in a university hospital. Perinatol Dergisi. 2005;13:86-90.

Prajapati VJ, Kacha AR, Kakkad KM, Damor PB, Nandaniya AM. Study of congential malformations in neonates born at tertiary care hospital. Natl J Community Med. 2015;6(1):30-34.

Swain S, Agarwal A, Bhatia BD. Congenital malformation at birth, Indian Pediatrics 1994; 31:1187-91.

Savaskar SV, Mundada SK, Pathan AS, Gajbhiye SF. Study of various antenatal factors associated with congenital anomalies born at tertiary health centre. International Journal of Recent Trends in Science and Technology. 2014;12(1):82-5.

Parmar A, Rathod SP, Patel SV, Patel SM. Study of Congenital Anomalies in Newborn. NJIRM. 2010;1(1):13-17.

Padma S, Ramakrishna D, Jijiya P, Ramana PV. Pattern of distribution of congenital anomalies in still born: a hospital based prospective study. International Journal of Pharma and Bio-sciences. 2011:2(2).

Mohanty C, Mishra OP, Das BK, Bhatia BD, Singh G. Congenital malformations in newborns: A study of 10,874 consecutive births. J Anat Soc India 1989,38:101-11.

Kulshreshtha R, Nath LM, Upadhyaya P. Congenital Malformation in live born infants in a rural community. Indian Pediatr. 1982.19:1003-9.

Verma M, Chhatwal J, Singh D. Congenital malformations – a retrospective study of 10,000 cases. Indian J Pediatr. 1991;58:245-52.

Gupta S, Gupta P, Soni JS. A study on incidence of various systemic congenital malformations and their associations with maternal factors. National Journal of Medical Research. 2012;2(1).

Shnorhavorian M, Bittner R, Wright JL, Schwartz SM. Maternal risk factors for congenital urinary anomalies: results of a population-based case-control study. Urology. 2011;78(5):1156-61.

Dart AB, Ruth CA, Sellers EA, Au W, Dean HJ. Maternal diabetes mellitus and congental anomalies of the kidney and urinary tract (CAKUT) in the child. Am J Kidney Dis. 2015;65(5):684-91.

Patel ZM, Adhia RA. Birth defect surveillance study. Indian J Pediatrics. 2005;2:489-90.

Taskade A. Congenital malformation at birth in central India. A rural medical college based data. Indian Journal of Human Genetics 2010;16:159-63.

Francine R, Pascale S, Aline H. Congenital anomalies: Prevalence and Risk factors. University Journal of Public Health. 2014;2(2):8-63.

Birth Defects: Report by the Secretariat. World Health Organization. Sixty-Third World Health Assembly;2010.

Shamnas M, Arya PS, Thottumkal VA, Deepak MG. Congenital anomalies: a major public health issue in India. International Journal of Pharmaceutical, Chemical and Biological Sciences. IJPCBS. 2013, 3(3),577-85.

Downloads

Published

2017-03-30

Issue

Section

Original Research Articles