Role of vitamin D in iron metabolism, a pilot study

Authors

  • Uma Pandey Department of Obstetrics & Gynaecology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, UP, India
  • Hema Divakar Department of Obstetrics & Gynaecology, Divakars Hospitals, Bengaluru, Karnataka, India

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20150735

Keywords:

Anaemia, Vitamin D, Vitamin D deficiency, Pregnancy, Iron metabolism

Abstract

Background: The objective of the study was to evaluate the effect of Vit D & Iron supplementation on Serum Hb level &Vit D level as compared to Iron supplementation alone. To evaluate the percentage responders in terms of Haemoglobin to Iron supplementation when Vit D is added as compared to only Iron supplemented. Vitamin D Deficiency is very prevalent in our country due to many reasons; therefore we also wanted to assess how deficient they are?

Methods: Recruited pregnant mothers were with 25 (OH) D <20ng/ml & Hb=8-10g/dl. Patients were randomized into groups using a computerized program. Group iron + Vitamin D : tablets containing fixed dose combination of vit D (1000 IU) + ferrous ascorbate (100mg of elemental iron) + folic acid (1 mg) + vit B12 (7.5 mcg) (1 tab/day) for 12 weeks. Group iron alone: tablets containing fixed dose combination of ferrous ascorbate (100 mg of elemental iron) + folic acid (1.1 mg) (1 tablet/day) for 12 weeks.

Results: There was no significant difference between the ages of patients of two groups. Parity and BMI were nearly same. Vit D level assessment at the recruitment in both groups is nearly same and also Hb level assessment at the recruitment in both groups is nearly same. The study shows that addition of Vitamin D to the Iron supplement does not increase the level of Hb any further as compared to the Iron administration alone.

Conclusions: This pilot study shows that administration of iron to Vitamin D does not influence the rise in haemoglobin level any greater than Iron administration alone. A larger sample size study is needed to prove this finding further.

References

Zittermann A. Vitamin D and disease prevention with special reference to cardiovascular disease. Prog Biophys Mol Biol. 2006;92:39-48.

Bischoff-Ferrari HA, Giovannucci E, Willet WC, Dietrich T, Dawson-Hughes B. Estimation of optimal serum concentration of 25-hydroxyvitamin D for multiple health outcomes. Am J Clin Nutr. 2006;84:18-28.

Holick MF, Garabedian M. Primer on the metabolic bone diseases and disorders of mineral metabolism, 6th Edn. American Society for Bone and Mineral Research, Washington, DC, 2006.

Bouillon R, Sarandeses LA, Allewaert K, Zhao J, Mascarenes JL, Mourino A, et al. Biologic activity of dihydroxylated 19-nor-(pre)vitamin D3. J Bone miner Res. 1993;8:1009-015.

DeLuca HF. Overview of general physiologic features and functions of vitamin D. Am J Clin Nutr 2004; 80: 1689S-1696S.

Dusso A, Brown A, Slatopolsky E. Extrarenal production of calcitriol. Semin Nephrol. 1994;14:144-55.

Penna G, Roncari A, Amuchastegui S, Daniel KC, Berti E, Colonna M, Adorini , Expression of the inhibitory receptors ILT3 on dendritic cells is dispensable for induction of CD4+ Foxp3+ regulatory T cells by 1,25-dihydroxy vitamin D3. 2005;106:3490-7.

Li YC Vitamin D regulation of the renin-angiotensin system. J Cell Biochem. 2003;88:327-31.

Chiu KC, Chu A, Go VL, Saad MF Hypovitaminosis D is associated with insulin resistance and beta cell dysfunction. Am J Clin Nutr. 2004;79:820-5.

Blazsek I, Farabos C, Quittet P, Labat ML, Bringuier AF, Triana BK, Machover D, Reynes M, Misset JL. Bone marrow stromal cell defects and 1 alpha, 25-dihydroxyvitamin D3 deficiency underlying human myeloid leukaemias. Cancer Detect Prev. 1996;20:31-2.

Reichel H, Koeffler HP, Norman AW. The role of vitamin D endocrine system in health and disease. N Eng J Med. 1989;320:980-91.

Norman W. Minireview; vitamin D receptor: new assignments for an already busy receptor. Endocrinology. 2006;147(12):5542-8.

Blazsek I, Farabos C, Quittet P, Labat ML, Bringuier AF, Triana BK, Machover D, Reynes M, Misset JL. Bone marrow stromal cell defects and 1 alpha, 25-dihydroxyvitamin D3 deficiency underlying human myeloid leukemias. Cancer Detect Prev. 1996;20:31-42.

Downloads

Published

2017-02-10

Issue

Section

Original Research Articles