Serum beta human chorionic gonadotropin and lipid profile in early second trimester (14-20 weeks) is a predictor of pregnancy-induced hypertension

Pradeeba Soundararajan, Poovathi Muthuramu, Munira Veerapandi, Rubini Mariyappan


Background: A variety of biological, biochemical, and biophysical markers implicated in the pathophysiology of pre-eclampsia during the last two decades have instigated the growing interest in this study to include both βhCG and lipid profile studies in the early second trimester as early predictors of pregnancy-induced hypertension. Early identification of at-risk women may help in taking timely preventive and curative management to prevent or delay complications associated with pregnancy-induced hypertension.

Methods: A prospective study was performed on 100 patients attending the outpatient department of the Obstetrics and Gynaecology of the Raja Mirasudar hospital. All the patients were screened for serum βhCG and serum lipid profile in their early second trimester (14-20 weeks) and followed up till their delivery. Comparative studies of serum βhCG and serum lipid profile were performed between those who remain normotensive (group I) and those who developed pregnancy-induced hypertension (group II).

Results: TG, HDL, VLDL, and LDL and BETA HCG values for those women who developed PIH (group II) were significantly higher than those who remain normotensive (group I), with p value of <0.01 which is statistically significant. HDL and βhCG values for group II were not higher than those in group I with p value >0.05 which is statistically insignificant.

Conclusions: Maternal lipid profile and BETA HCG in second trimester is very good noninvasive test which can be used for prediction of pregnancy-induced hypertension before its clinical onset.


Pregnancy-induced hypertension, βHCG, TG, Total cholesterol, VLDL, LDL

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Zimmer C. Silent struggle: a new theory. The New York Times. 2006;11:1-4.

Rrund G, Aruan DA Clinical biochemistry of pre eclampsia and related liver disease of pregnancy: a review clinical chimicaacta. 1990:123-52.

Hypertensive disordfuncter in pregnancy. In: Cunningham FG, lenevo KJ, Bloom SL, Hauth JC, Gilstap LC, Wenstrom KP , eds. Williams obstetrics 22nd edn. USA: Mc Graw Hill Publications; 2005:762-3.

Bussen S, Sufferlin M, Steck T. Plasma endothelin and big endothelin levels in women with severe pre eclampsia or HELLP syndrome. Arch Gynaecol Obstet. 1999;262:113-9.

Roberts JM. Endothelial dysfunction in pre eclampsia seminreprodendocrinol.1998:5-15.

Yaron Y, Cherry M, Kramer RL. Second trimester maternal serum marker: maternal serum alpha fetoprotein, beta human gonadotrophin and theirs various combinations as a predictors of pregnancy outcome. Am J Obstet Gynecol. 1999;181:968-74.

Clausen T, Djurovic S, Henriksen T. Dyslipidemia in early second trimester and risk of pre- eclampsia. Br J Obstet Gynaecol. 1996;103:117-22.

Bechmannn CRB, Ling FW, Barzansky BM, Bates GW, Herbect WNP, Laube DW, et al. Hypertension in pregnancy. In obstetrics and gynaecology 2nd edn. Baltimore Waverly company. 1995:137-43.

Morrisink LP. Heringa MP. Beekhuis JR. De Wolf BTHM, Mantingh A. The association between hypertensive disorders of pregnancy and abnormal second trimester maternal serum levels of HCG and alpha fetoprotein. Obstet Gynecol. 1997;89:660-70.

Chesley LC. Hypertensive disorders of pregnancy. New York Appleton-century-crofts.1978.

Lorentzen B, Drevon C, Endresen M. Fatty acid pattern of esterified and free fatty acids in sera of women with normal and pre eclamptc pregnancy. Br J Obstet gynaecol. 1995;102:530-37.

HladunewichM, Karumanchi SA, L afayette R. Pathophysiology of the clinical manifestations of pre eclampsia. Clin J AM SOC Nephrol. 2007;543-9.

Correlation between lipid profiles with pre eclampsia. Turpin. Journal of obstet Japan. 2003:141-146.

Meculure N, Thompson W. Pre eclampsia. In: Senguptapsedts Gratacos, merkern. Journal of obstet gynac association of high levels of lipid with GHT.

Franz H, Wender D. A controlled study with lipoproteins in PIH. Arch gynaecol obstet. 1992;252:81-6.

Vallient P, David E, Constant L. Validity in nulliparas of increased beta human chorionic gonadotropin in the mid trimester and adverse pregnancy outcome. Nepron. 1996;72:557-63.

Daniel A Enqurobabrie, William, yilkorka pathogenesis of GHT with lipid profile.

Everke. Correlation between maternal serum beta hcg and lipid profile in JM obstet gynac. 2004;197:81-96.

Gonen R, Perez R, David M. The association between un explained second trimester maternal serum HCG elevation and pregnancy complication. Obstet gynnecol. 1992;80:83-5.