Retrospective study factors related to preterm birth in Government Raja Mirasudar hospital and obstetric and perinatal outcome

Pradeepa Soundarajan, Poovathi Muthuramu, Munira Veerapandi, Rubini Mariappan


Background: Preterm birth is a leading cause of perinatal mortality and long-term morbidity as well as the long-term health consequences and cognitive outcomes. Present study was conducted to determine prevalence and risk factors and obstetric & perinatal outcome associated with preterm birth in Rajamirasudar Hospital, Thanjavur.

Methods: A case control study was conducted between Mar 2015 - Sep 2015 in Rajamirasudar Hospital, Thanjavur. All the live new-borns during the study period were investigated. Of 6805 live births during the study period 356 births occurred in <37 weeks were taken as a case and 579 term neonates were taken as a control group. Data were obtained through review of prenatal and hospital delivery records. Univariate and multivariate logistic regression analysis were applied to obtain magnitude of association between independent variables and preterm birth.

Results: The prevalence rate of preterm birth was 5.6%. History of previous preterm birth (OR=12.7,CI: 3.9-40.4, p<0.001), hypertension (OR=7.3, CI: 2.1-25.4, p=0.002), oligohydramnios (OR=3.9, CI:1.6-9.5, p=0.002), diabetics (OR=3.7, CI: 1.1-11.8, p=0.024),  premature rupture of membrane (OR=3.1, CI:1.9-4.9, p=0.000), hypothyroid (OR=2.0, CI: 1.0-3.8, p=0.037), prepregnancy low BMI (OR=2.0, CI: 1.1-3.8, p=0.015), urinary tract infection in 26-30 weeks , (OR=1. 8 CI:1.0-3.2, p=0.04) were determined as significant risk factors for preterm birth.

Conclusions: Early detection and treatment of diseases or disorders among pregnant women especially hypertension, Oligohydramnios, diabetics, hypothyroid, urinary tract infection, pre pregnancy low BMI as well as the improving health care quality delivered to pregnant women may reduce preterm prevalence rate and also reduce neonatal morbidity and mortality.


Prevalence, Preterm birth, Risk factors, Perinatal outcome

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Beck S, Wojdyla D, Say L, Betran AP, Merialdi M, Requejo JH, et al. The worldwide incidence of preterm birth: a systematic review of maternal mortality and morbidity. Bull World Health Organ. 2010;88:31-8.

Sonkusare S, Rai L, Naik P. preterm birth: mode of delivery and neonatal outcome. Med J Malaysia. 2009;64:303-06.

Modarres SZ, Amooian B, Movahed SB, Mohamadi M. periodontal health in mothers of preterm and term infants. Taiwan J Obstet Gynecol. 2007;46:157-61.

Goldenberg RL, Culhane JF, Jams JD, Rometo R. epidemiology and cause of preterm birth. Lancet. 2008;371:75-83.

Renzo GCD, Giardina I, Rosati A, Clerici G, Torricelli M, Petraglia F. maternal risk factors for preterm birth: a country-based population analysis. Eur J Obstet Gynecol. 2011;3:1-5.

Mirzaie F, Mohammad-Alizadeh S. Contributing Factors of preterm delivery in parturient in a university hospital in Iran. Saudi Med J. 2007;28:400-4.

Mahmoodi Z, Hoseini F, Sadeghi Avval Shahr H, Ghodsi Z, Amini L. The Association between Maternal Factors and Preterm Birth and Premature Rapture of Membranes. J Fam Reprod Health. 2010;4:135-9.

Nabavizadeh SH, Malekzadeh M, Mousavizadeh A, Ghaffarian Shirazi HR, Ghaffari P, Karshenas N, et al. Retrospective study of Factors related to preterm labor in Yasuj, Iran. Int J Gen Med. 2012:1013-10.

Raisanen S, Gissler M, Saari J, Kramer M, Heinonen S. Contribution of risk factors to Extremely, Very and Moderately Preterm Birts-Register-Based Analysis of 1,390.742 Singleton Births. PLOS One. 2013;8:1-7.

Dolatian M, Mirabzadeh A, Forouzan AS, Sajjadi H, Alavi Majd H, Moafi F. Preterm Delivery and Psycho-Social Determinants of Health Based on World Health Organization Model in Iran: A Narrative Review. Glob J Health Sci. 2013;5:52-64.

Cunningham FG, Leveno KJ, Hauth JC, editors. Williams obstetrics. 23th Ed. New York: McGraw Hill; 2010.

Jafari F, Eftekhar H, Pourreza A, Mousavi J. Sosio-economic and medical determination of low birth weight in iran: 20 years after establishment of a primary health care network. Public Health.2010;124:153-7.

Vallandares E, Ellsberg M, Pena R, Hogberg U, Persson LA. Physical partner abuse during pregnancy: a risk factor for low birth weight in Nicaragua. Obstet Gynecol. 2002;100:700-4.

Nguyen N, Savitz DA, Thorp JM. Risk factors for preterm birth in Vietnam. Int J Gynaecol Obstet. 2004;86:70-8.

Khalajinia Z, Jandaghi G. Maternal risk factors for preterm birth: a country-based population analysis. Eur J Obstet Gynecol Reprod Biol. 2012;159:342-6.

Bernabe JV, Soriano T, Albaladejo R, Juarranz M, Calle ME, Martinez D, et al. Risk factors for low birth weight: a review. Eur J Obstet Gynecol Reprod Biol. 2004;116:3-15.

Chin LO C, Hsu JJ, Hsieh CC, Hsieh TT, Hung T. Risk factors for spontaneous preterm delivery before 34 weeks of gestation among Taiwanese women. Taiwan J Obstet Gynecol. 2007;46:389-93.

Coker AL, Sanderson M, Dong B. Partner violence during pregnancy and pregnancy outcomes. Paediatr Perinat Epidemiol. 2004;18:260-90.

Schieve L, Handler A, Hershow R, Persky V, Davis F. Urinary tract infection during pregnancy: its association with maternal morbidity and perinatal outcome. Am J Public Health. 1994;84:806-15.

Rodrigues T, Rocha L, Barros H. Physical abuse during pregnancy and preterm delivery. AM J Obstet Gynecol. 2008;198:1-6.

De Sutter P, Bontinck J, Schutysers V, Van der Elst J, Gerris J, Dhont M. First trimester bleeding and pregnancy outcome in singletons after assisted reproduction. Hum Reprod. 2006;21:1907-11.

Strobino B, Pantel-Silverman J. Gestational vaginal bleeding and pregnancy outcome. Am J Epidemiol. 1989;129:806-15.