DOI: http://dx.doi.org/10.18203/2320-1770.ijrcog20162642

A study on clinico-histopathological patterns of ovarian tumors

Vinitha Wills, Rachel Mathew

Abstract


Background: Ovarian tumors are an increasing cause for morbidity and mortality world over. The objective of this study was to study the distribution of ovarian tumors histopathologically in different age groups and their various clinical presentations.

Methods: Ninety eight patients who presented with 140 ovarian lesions on either or both sides were analyzed during a study period of one year and a further one year follow-up of patients with malignant tumors were done in a Tertiary teaching hospital.

Results: There were 140 lesions comprising of 40% of neoplastic lesions and 60% of non-neoplastic lesions. Among the ovarian neoplasms, 91.1% were benign lesions, 7.1% malignant and 1.8% were borderline malignant. Serous tumors were the commonest tumors (46.4%) followed by mucinous tumors and germ cell tumors (23.2% each). Endometriotic cysts (34.5%) were the commonest non-neoplastic lesions. The distribution of benign tumors in the reproductive age groups was only slightly more than that in the perimenopausal age group. All malignant tumors were in the perimenopausal age group. Menstrual complaints like irregular bleeding and menorrhagia formed the majority of clinical presentation. Bilaterality of lesions was seen in 16 patients.

Conclusions: Benign ovarian tumors are common in reproductive age group as well as perimenopausal age group. The most common neoplasm present was surface epithelial tumors - serous tumors followed by germ cell and mucinous tumors. The most common non-neoplastic lesions were endometriotic cysts and inclusion cysts. Bilateral involvement was uncommon with preponderance of lesions on the right side. Common clinical presentations were menstrual problems and abdominal pain.


Keywords


Ovarian neoplasm, Histopathology, Clinical presentation

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References


Berek JS, Natarajan S. Ovarian and fallopian tube cancer. In: Berek JS (Editor). Berek and Novak’s Gynaecology 15th Ed. Wolter Kluwer Health (India) Private Limited; 2012:1350-1427.

Jaffer Y, Ehsan N, Ambreen. Clinical presentation of ovarian tumors. Journal of Surgery Pakistan (International). 2013;18(2):82-6.

Brown DL, Dudiak KM, Laing FC. Adnexal masses: US characterization and reporting. Radiology. 2010;254(2):342-54.

Gentry-Maharaj A, Menon U. Screening for ovarian cancer in the general population. Best Pract Res Clin Obstet Gynaecol. 2012;26:243-56.

Attunueci CA, Ball HG, Zweizig SL, Chen AH. Differences in symptoms between patients with benign and malignant ovarian neoplasms. Am J Obstet Gynecol. 2004;190:1435-7.

Rock JA, Jones HW. Ovarian cancer; etiology, screening and surgery. Te Linde’s Operative Gynaecology, 10th Ed., Lippincott Williams and Wilkins; 2011:1307-1339.

Coleman MP, Estere J, Damiecki P. Trends in Incidence and Mortality, Lyon, IARC. 1993;121:1-801.

Seshadri L. Malignant diseases of the ovary and fallopian tube. In: Essentials of Gynaecology, 1st Ed. Wolters Kluwer (India) of Lippincot Williams and Wilkins; 2011:418-440.

Swamy GG, Satyanarayana N. Clinicopathological analysis of ovarian tumor - a study on five year samples. Nepal Med Coll J. 2010;12(4):221-3.

Mondal SK, Bandopadhyay R, Nag DR, Roychowdhury S, Mondal PK, Sinha SK. Histological pattern, bilaterality and clinical evaluation of 957 ovarian neoplasms. A 10 year study in a tertiary hospital of Eastern India. J Can Res Ther. 2011;7:433-7.

Gupta N, Bisht D, Agarwal AK, Sharma VK. Retrospective and prospective study of ovarian tumors and tumor - like lesions. Indian J Pathol Microbiol. 2007;50:525-7.

Ahmad Z, Kayani N, Hasan SH, Muzaffar S, Gill MS. Histological pattern of ovarian neoplasm. J Pak Med Assoc. 2000;50:416-9.

Thanikasalam K, Ho CM, Adeed N, Shahidan MN, Azizah WK. Links pattern of ovarian tumors among Malaysian women at General Hospital, Kaula Lumpur. Med J Malaysia. 1992;47:139-46.

Al-Fozan H, Tulandi T. Left lateral predisposition of endometriosis and endometrioma. Obstet Gynaecol. 2003;101:164-6.

Carey M, Krik ME. Necrotic pseudoxanthomatous nodules of the omentum and peritoneum. A peculiar reaction to endometriotic cyst contents. Obstet Gynaecol. 1993;82:65-52.

Manivasakam J, Arounssalame B. A study of benign adnexal masses. Int J Reprod Contracept Obstet Gynecol. 2012;1(1):12-6.

Sharadha SO, Sridevi TA, Renukadevi TK, Gowri R, Binayak D, Indira V. Ovarian masses: changing clinico histopathological trends. The Journal of Obstetrics and Gynaecology of India. 2015;65(1):34-8.

Ashraf A, Shaikh S, Ishfaq A. The relative frequency and histopathological pattern of ovarian masses. Biomedica. 2013;28:98-102.

Poole J, Nordin A. Trent cancer registry. Profile of ovarian cancer in England; 2012.

Quirk JT, Natarajan N. Ovarian cancer incidence in the United States 1992-1999. Gynaecol Oncol. 2005;97:519-23.

Shah S, Hishikar VA. Incidence and management of Ovarian tumours. Bombay Hospital J. 2008;50:30-3.

Wasim T, Majrroh A, Siddiq S. Comparison of clinical presentation of benign and malignant ovarian tumors. J Pak Med Assoc. 2009;59:18-21.

Mankar DV, Jain GK. Histopathological profile of ovarian tumors: a twelve year institutional experience. Muller J Med Sci Res. 2015;6:107-11.

Kanthikar SN, Dravid NV, Deore PN, Nikumbh DB, Suryawanshi KH. Clinico-histopathological analysis of neoplastic and non-neoplastic lesions of the ovary: a 3 year prospective study in Dhule, North Maharashtra, India. Journal of Clinical and Diagnostic Research. 2014;8(8):FCO4-FCO7.

Winter Jo TV, Simmons PS, Podratz C. Surgical treated adnexal masses in infancy, childhood and adolescence. Am J Ostet Gynecol. 1994;170:1780-9.

Jha R, Karki S. Histological pattern of ovarian tumors and their age distribution. Nepal Med Coll J. 2008;10:81-5.