Prevalence of pre-gestational diabetes among the antenatal women attending a tertiary care center

Authors

  • Renji S. R. Department of Obstetrics and Gynecology, Sree Avittom Thirunal Hospital, Government Medical College, Trivandrum, Kerala, India
  • Sujatha Thankappan Lekshmi Department of Obstetrics and Gynecology, Sree Avittom Thirunal Hospital, Government Medical College, Trivandrum, Kerala, India
  • Nirmala Chellamma Department of Obstetrics and Gynecology, Sree Avittom Thirunal Hospital, Government Medical College, Trivandrum, Kerala, India

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20170466

Keywords:

Gestational diabetes, HbA1C, Pre-gestational diabetes

Abstract

Background: Number of pregnant women with preexisting diabetes is increasing. Hence the detection and management of diabetes from the beginning of pregnancy itself will help to improve the fetal and maternal outcome. Aim of the study was to determine the prevalence of pre-gestational diabetes among the antenatal women attending a tertiary care center and to study the associated factors.

Methods: This was a cross sectional study conducted in SAT hospital, Government Medical College, Trivandrum, Kerala, India for one year. HbA1C was the test used to diagnose diabetes. 400 women attending the OP in their first trimester were selected after informed consent. Socio demographic factors assessed by a structured questionnaire.  Blood samples were taken for HbA1C. Diagnosis of diabetes was made at levels of HbA1C ≥6.5%. Statistical tests used were mean, standard deviation, chi-square and odds ratio.

Results: Prevalence of pre-gestational diabetes was 3.8%.in our study. Main associations were age more than 25 years, body mass index, family history of diabetes, history of intra uterine death, gestational diabetes in previous pregnancy, candidiasis and thyroid disease.

Conclusions: Screening of all pregnant women in first trimester itself for diabetes will help in early detection of pre-gestational diabetes, so that anticipation of adverse outcomes and proper management can be done in such cases.

References

Chen L, Magliano DJ, Zimmet PZ. The worldwide epidemiology of type 2 diabetes mellitus present and future perspectives. Nature Reviews Endocrinology. 2012;8:228-36.

Tankova T, Chakarova N, Iliana DA. Assessment of HbA1c as a diagnostic tool in diabetes and prediabetes. Acta Diabetologica. 2012;49(5):371-8.

Rajput R, Yadav Y, Rajput M, Nanda S. Utility of HbA1c for diagnosis of gestational diabetes mellitus. Diabetes Research Clinical Practice. 2012;98(1):104-7.

Anjana RM, Pradeepa R, Deepa M, Datta M, Sudha V, Unnikrishnan RA, et al. Prevalence of diabetes and prediabetes (impaired fasting glucose and/or impaired glucose tolerance) in urban and rural India: phase I results of the Indian council of medical research India. Diabetes. 2011;54(12):3022-7.

Mohan V, Sandeep S, Deepa R, Shah B, Varghese C. Epidemiology of type 2 diabetes: Indian scenario. Indian J Med Res. 2007;125(3):217-30.

Doreen MR, Edwards AL, Danielle A, Lawrence WS, Peter MS, Norton P, et al. Association of socio-economic status with diabetes prevalence and utilization of diabetes care services. BMC Health Services Research. 2006;6:124.

Evans JM, Newton RW, Ruta DA, Macdonald TM, Morris AD. Socio-economic status, obesity and prevalence of Type 1 and Type 2 diabetes mellitus Diabet Med. 2000;17(6):478-80.

Lindsay RS, Hanson RL, Bennett PH, Knowler WC. Secular trends in birth weight, BMI and diabetes in the offspring of diabetic mothers. Diabetes Care. 2000;23(9):1249-54.

William CH, Rosario MG, Alka AM. BMI cut points to identify at-risk asian americans for type 2 diabetes screening. Diabetes Care. 2015;38(1):150-8.

Wright AD, Nicholson HO, Pollock A, Taylor TG. Betts spontaneous abortion and diabetes mellitus. Postgrad Med J. 1983;59(691):295-8.

Korteweg FJ, Jaap HM, Erwich. Evaluation of 1025 fetal deaths: proposed diagnostic workup. Am J Obst Gynec. 2012;206(1):1-12.

Tennant PW, Glinianaia SV, Bilous RW. Bell, pre-existing diabetes, maternal glycated haemoglobin and the risks of fetal and infant death: a population-based study. Diabetologia. 2014;57(2):285-94.

Clausen TD, Mathiesen ER, Hansen T. High prevalence of type 2 diabetes and pre-diabetes in adult offspring of women with gestational diabetes mellitus or type 1 diabetes the role of intrauterine hyperglycemia. Diabetes Care. 2008;31(2):15-8.

Haroush BA, Yogev Y, Hod M. Epidemiology of gestational diabetes mellitus and its association with type 2 diabetes. Diabet Med. 2004;21(2):103-13.

Radha V, Mohan V. Genetic predisposition to type 2 diabetes among Asian. Indian J Med Res. 2007;125:259-74.

Hage M, Zantout MS, Azar ST. Thyroid disorders and diabetes mellitus. J Thyroid Res. 2011;439463:7.

Kadiyala R, Peter R, Okosieme OE. Thyroid dysfunction in patients with diabetes: clinical implications and screening strategies. Int J Clin Pract. 2010;64(8):1130-9.

Malazy OT, Shariat M, Heshmat R, Majlesi F, Alimohammadian M, Tabari NK, et al. Vulvovaginal candidiasis and its related factors in diabetic women. Taiwan J Obstet Gynecol. 2007;46(4):399-404.

Goswami R, Dadhwal V, Tejaswi S, Datta K, Paul A, Haricharan RN, et al. Species-specific prevalence of vaginal candidiasis among patients with diabetes mellitus and its relation to their glycaemic status. J Infect. 2000;41(2):162-6.

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Published

2017-02-19

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Original Research Articles