Outcome of clinical hypothyroidism in pregnancy: a case control study

Authors

  • John B. Lopamudra Department of Obstetrics and Gynecology, Mahatma Gandhi Medical College and Research Institute, Pondicherry
  • Rani P. Reddi Department of Obstetrics and Gynecology, Mahatma Gandhi Medical College and Research Institute, Pondicherry
  • Seetesh Ghose Department of Obstetrics and Gynecology, Mahatma Gandhi Medical College and Research Institute, Pondicherry

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20161705

Keywords:

Hypothyroidism, Pregnancy, Diabetes, Hypertension

Abstract

Background: Hypothyroidism in pregnancy is generally associated with various adverse outcomes. Also worldwide, there is an increased awareness about morbidity caused by this endocrinological disorder in pregnancy .This study is undertaken to evaluate the outcome of this condition in pregnancy.

Methods: 144 newly diagnosed clinical hypothyroid pregnant women were taken as the case group and 145 age and parity matched euthyroid pregnant women were taken as controls. The outcome compared in between these two groups were pregnancy complications like gestational diabetes and hypertension , oligohydramnios, intrauterine growth restriction , intrauterine demise, Caesarean section rates and it’s indication as well as neonatal outcome like birth weight and need for neonatal intensive care.

Results: Clinical hypothyroidism in pregnancy constituted 6.1% of the total number of deliveries. There was a significantly higher number of gestational diabetes in the case group (p=0.0001). Caesarean sections done for the indication of foetal distress was significantly higher when compared with the control group (p=0.00002). Large for gestational age babies were more common in case group.

Conclusions: Clinical hypothyroidism in pregnancy even when treated adequately might lead to complications.

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Published

2017-01-05

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Original Research Articles