Efficacy of autologous platelet rich plasma for ovarian rejuvenation in infertile women having poor ovarian reserve

Authors

  • Jesmine Banu Department of Reproductive Endocrinology and Infertility, BSMMU, Dhaka, Bangladesh
  • Mostafa Tarique Department of Reproductive Endocrinology and Infertility, BSMMU, Dhaka, Bangladesh
  • Nishat Jahan Department of Gynecology, Nabinagar Upazila Health Complex, Brahmanbaria, Bangladesh
  • Nastaran Lasker Department of Reproductive Endocrinology and Infertility, BSMMU, Dhaka, Bangladesh
  • Nighat Sultana Department of Reproductive Endocrinology and Infertility, BSMMU, Dhaka, Bangladesh
  • Chowdhury Faisal Alamgir Department of Urology, New Cross Hospital, The Royal Wolverhampton NHS Trust, United Kingdom
  • Maliha Darmini Department of Gynecology, Mymensingh Medical College and Hospital, Mymensingh, Bangladesh
  • Sirajum Munira Department of Reproductive Endocrinology and Infertility, BSMMU, Dhaka, Bangladesh

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20222782

Keywords:

Infusion, Platelet, Plasma, Rejuvenation, Ovarian, Infertile

Abstract

Background: Poor ovarian reserve (POR) is a condition in which the ovary loses its normal reproductive potential and compromising fertility. Normal function of the ovaries and adequate good quality follicles are responsible for the reproductive process of a woman. Various treatment methods exist for POR, but the present study was conducted to observe the effectiveness of platelet rich plasma infusion through measurement of AMH and AFC values and pregnancy outcomes.

Methods: This prospective observational study was done in the department of reproductive endocrinology and infertility from July 2019 to June 2022. A total of 60 patients with poor ovarian reserve were recruited maintaining inclusion and exclusion criteria.

Results: Mean age of the participants was 36.4 years, with 78.32% of the participants being housewives and 21.68% being service workers. 65.38% had education below SSC levels. 72.46% had primary infertility while 27.54% had secondary infertility. At first cycle, compared to baseline counts, mean±SD AMH had increased by 0.04±0.15 ng/dl, and mean±SD AFC had increased by 1.34±1.89 in number. During second cycle post-PRP, the mean difference of AMH and AFC was 0.18±0.21 ng/dl and 2.17±1.71 in a positive manner. By final follow-up, pregnancy rate was 20% among patients.

Conclusions: The study observed significant improvement in AMH and AFC values following PRP infusion. The improvement of both values was gradual, and increase of AMH values were observed up to second post-PRP menstrual cycle, while AFC increased till third cycle post-PRP. Among 60 patient twelve (12) had pregnancy (20%).

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Published

2022-10-28

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Original Research Articles