Serum uric acid in first trimester as a predictor for the diagnosis of gestational diabetes mellitus-a prospective study

Authors

  • Suguna Srinivasan Department of Obstetrics and Gynecology, Shri Sathya Sai Medical College and Research Institute, Ammapettai, Chengulpet, Tamil Nadu, India

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20222642

Keywords:

GDM, Glucose tolerance test, Serum uric acid, Gestational age, First trimester, Screening test

Abstract

Background: Gestational diabetes mellitus (GDM) is common worldwide. It is a disorder of carbohydrate metabolism. Indian women have increased risk of developing GDM, and leads to adverse Maternal and neonatal outcomes. Women with raised uric acid in pregnancy are interlinked with more incidence of unfavorable outcomes in pregnancy such as GDM. Hence this study is done to prove the utility of uric acid in early diagnosis of GDM by starting early treatment so as to reduce the complications in pregnant women.

Methods: The antenatal women are screened for GDM by serum uric acid levels with gestational age <12 weeks. These antenatal women are followed up around 24-28 weeks and oral glucose tolerance test is done and evaluated for GDM using ADA criteria.

Results: In our study, serum uric acid cut–off of 4.2 mg/dl had a positive association with the GTT values with p value less than 0.05 (p=0.018). In this study, in the raised serum uric acid category, 8 (19%) were positive for GTT and among the normal serum uric acid category, 3 (4.7%) were positive for GTT. Thus, we observe from our study that elevated levels of uric acid during the first trimester is interlinked with prediction of gestational diabetes.

Conclusions: The diagnosis of serum uric acid level in first trimester as a predictor of GDM is easy and economical and it can be used as a screening test for prediction of GDM.

Author Biography

Suguna Srinivasan, Department of Obstetrics and Gynecology, Shri Sathya Sai Medical College and Research Institute, Ammapettai, Chengulpet, Tamil Nadu, India

Associate  professor, Department of Obstetrics and Gynecology , shri Sathya sai medical college and research institute .

References

Wokoma FS, John CT, Enyindah CE. Gestational diabetes mellitus in a Nigerian antenatal population. Trop J obstet Gynaecol. 2001;18(2):56-60.

Baynes HW. classification, pathophysiology, diagnosis and management of diabetes mellitus. J diabetes metab. 2015;6(5):1-9.

Raja MW. A study to estimate the prevalence of gestational diabetes mellitus in an urban block of Kashmir valley (North India). Int J med Sci Public Health. 2014;3(2):191-5.

Patel ML, singh M, Sachan P, Sachan R. Outcome in gestational diabetes mellitus after various treatment modality: A tertiary center experience in North India. Ann Trop Med Public Health. 2018;11(4):140

Laughon SK, Catov J, Provins T, Roberts JM, Gandley RE. Elevated first-trimester uric acid concentrations are associated with the development of gestational diabetes. AM J Obstet. 2009;201(4):402.el-5.

Wolak T, Sergienko R, Wiznitzer A, Paran E, Sheiner E. High uric acid level during the first 20 weeks of pregnancy is associated with higher risk for gestational diabetes mellitus and mild preeclampsia. Hypertension Pregnancy. 2012;31(3):307-15.

Rasika C, Samal S, Ghosem S. Association of elevated first trimester serum uric acid levels with development of GDM. Clin Diagn. 2014(12):11-5.

Ganta SJ, Kulkarni SR, First trimester uric acid level: a reliable marker for gestational diabetes mellitus. Int J Reprod Contracept Obs Gynecol. 2019;8:2358-62.

El-Gharib MN, Mahfouz AE, Morad MA, Farahat MA. Prediction of gestational diabetes by measuring first trimester maternal serum uric acid concentration. J Basic clin Reprod Sci. 2013;2(1):27-31.

Baliga P, Thunga S. uric acid levels in early pregnancy as a predictor of preeclampsia and gestational diabetes mellitus. Int J Recent sci. 2015;6(6):4611-5.

Rao CN, Uthraraj K. Elevated 1st trimester serum uric acid-a risk for gestational diabetes mellitus among South-Indians: a prospective observational, longitudinal study. Int J Reprod contracept obstet Gynecol. 2017;6:4923-7.

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Published

2022-10-28

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Section

Original Research Articles