A rare case of malignant Brenner tumour of ovary: a case report

Authors

  • Syeda Z. Jabeen Mahadevappa Department of Obstetrics and Gynaecology, Mahadevappa Rampure Medical College, Kalaburagi, Karnataka, IndiaRampure Medical College
  • Laxmi Itagi Department of Obstetrics and Gynaecology, Mahadevappa Rampure Medical College, Kalaburagi, Karnataka, India
  • Neeta Harwal Department of Obstetrics and Gynaecology, Mahadevappa Rampure Medical College, Kalaburagi, Karnataka, India

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20222330

Keywords:

Brenner tumour of ovary, Malignant, Meigs syndrome

Abstract

Ovarian Brenner tumor (BT) is a rare epithelial ovarian cancer that accounts for less than 2% of ovarian neoplasms. The World Health Organization (WHO) classifies Brenner tumors into three categories: benign, borderline and malignant. Malignant Brenner tumors (MBT) of the ovary are 3-5% of Brenner tumors. They carry a poor prognosis. They generally affect women during the perimenopausal and postmenopausal periods and presents with mass per abdomen. A case of 55 years old Female with complaints of post-menopausal bleeding since 3-4 months and pain abdomen since 2 days. Patient attained menopause 20 years ago. Clinically patient appeared stable. On per abdomen hypogastric fullness +, dull note heard over the region. On per speculum examination altered minimal bleeding +, on bimanual examination, mass 10×6 cm in hypogastric region felt separately from fundus of uterus. Serum markers were: beta-human chorionic gonadotropin (b-hCG) – 0.26, alpha-fetoprotein (AFP) – 1.92, CA 125 – 84.18 and anti-Müllerian hormone (AMH) <0.010. Magnetic resonance imaging (MRI) scan showed right ovarian malignant tumour 10.6×14.2×16 cm. Patient was operated and frozen section was sent which confirmed Brenner tumour. Histopathological reporting- malignant Brenner tumour- right ovary. Left ovary and omentum were unremarkable. Ascitic fluid showed malignant cells. Patient was discharged and referred to oncologists. Incidence of malignant Brenner tumour is <2% which makes it uncommon, histopathologically consists of transitional epithelium. We report a case of ovarian malignant Brenner tumour, detailing the clinical presentation, diagnosis, pathologic review, imaging findings, and management.

References

Lee KR, Tavassoli FA, Prat J, IARC Press. Tumors of the ovary and peritoneum. In: World Health Organization Classification of Tumours. Pathology and Genetics of Tumors of the breast and Female Genital Organs. 2003;113-45.

Lang SM, Mills AM, Cantrell LA. Malignant Brenner tumor of the ovary: review and case report. Gynec Oncol Rep. 2017;22:26-31.

Gezginc K, Kartatayli R, Yazici F. Malignant Brenner tumor of the ovary: analysis of 13 cases. Int J Clin Oncol. 2012;17(4):324-9.

Han JH, Kim DY, Lee SW. Intensive systemic chemotherapy is effective against recurrent malignant Brenner tumor of the ovary: an analysis of 10 cases within a single center. Taiwan Obstet Gynecol. 2015;54(2):178-82.

Nasioudis D, Sisti G, Holcomb K, Kanninen T, Witkins SS. Malignant Brenner tumors of the ovary: a population-based analysis. Gynecol Oncol. 2016;142:44-9.

Ahr A, Arnold G, Goring UJ. Cytology of ascetic fluid in a patient with metastasizing malignant Brenner tumor of the ovary: a case report. Acta Cytol. 1997;41(4):1299-304.

Akman L, Akdemir A, Terek MC, Zekiogiu O. Ovarian malignant Brenner tumor in patients over 65 years of age. Kaohsiung J Med Sci. 2014;30(3):159-60.

Baizabal-Carvallo JF, Barragan-Campos HM, Alonso-Juarez M. Dural metastases as presentation of a Brenner tumor. J Clin Neurosci. 2010;17(4):524-6.

Beck H, Raahave D, Bolesen P. A malignant Brenner tumour of the ovary with subcutaneous metastases. Acta Pathol Microbiol Scand. 1977;85(6):859-63.

Chen KT. Bilateral malignant Brenner tumor of the ovary. J Surg Oncol. 1984;26(3):194-7.

Downloads

Published

2022-08-29

Issue

Section

Case Reports