Predicting risk and prognosis of preeclampsia by evaluating platelet indices

Authors

  • Shaily Agarwal Department of Obstetrics and Gynecology, GSVM Medical College, Kanpur, Uttar Pradesh, India
  • Renu Gupta Department of Obstetrics and Gynecology, Government Medical College, Kannauj, Uttar Pradesh, India
  • Divya Dwivedi Department of Obstetrics and Gynecology, GSVM Medical College, Kanpur, Uttar Pradesh, India
  • Chayanika Kala Department of Obstetrics and Gynecology, GSVM Medical College, Kanpur, Uttar Pradesh, India
  • Mrinalini Singh Department of Obstetrics and Gynecology, GSVM Medical College, Kanpur, Uttar Pradesh, India

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20222308

Keywords:

Pregnancy, Preeclampsia, Platelet count, Mean platelet volume, Platelet distribution width

Abstract

Background: Preeclampsia is an obstetric disorder affecting 2-8% pregnancies globally and 8-10% pregnancies in India. The study was conducted to evaluate platelet count, mean platelet volume and platelet distribution width as potential predictor of preeclampsia. It also aimed to see if these platelet indices have a prognostic significance in determining the preeclampsia severity.

Methods: A prospective study was conducted on 120 pregnant women at 20 to 24 weeks of gestation with singleton pregnancy. At monthly intervals CBC (complete blood count) was done from 20 to 24 weeks till delivery and 7 days after delivery. Data with increasing gestation were collected, analysed and expressed as mean, standard deviations and correlation coefficients.

Results: We observed significant decrease in PC and increase in MPV and PDW in patients with preeclampsia compared to normotensive patients. We also observed that it was more significant in severe preeclampsia than non-severe preeclampsia. The r value of PC for normotensive, non-severe and severe preeclampsia was -0.58, -0.59 and -0.94 respectively. The r value of MPV for normotensive, non-severe and severe preeclampsia was 0.89, 0.97 and 0.98 respectively. The r value of PDW for normotensive, non-severe and severe preeclampsia was 0.98, 0.98 and 0.99 respectively.

Conclusions: Patients with preeclampsia are more likely to have changes in PC, MPV and PDW, which can be observed in early pregnancy. Thus, estimation of PC, MPV and PDW can be considered as an early, simple and cost-effective procedure in the estimating the severity of preeclampsia

Author Biographies

Shaily Agarwal, Department of Obstetrics and Gynecology, GSVM Medical College, Kanpur, Uttar Pradesh, India

PROFESSOR,

OBSTETRICS & GYNAECOLOGY

GSVM MEDICAL COLLEGE , KANPUR

Renu Gupta, Department of Obstetrics and Gynecology, Government Medical College, Kannauj, Uttar Pradesh, India

PROFESSOR,

OBSTETRICS & GYNAECOLOGY

GSVM MEDICAL COLLEGE , KANPUR

Divya Dwivedi, Department of Obstetrics and Gynecology, GSVM Medical College, Kanpur, Uttar Pradesh, India

ASSISTANT PROFESSOR,

OBSTETRICS & GYNAECOLOGY

GSVM MEDICAL COLLEGE , KANPUR

Chayanika Kala, Department of Obstetrics and Gynecology, GSVM Medical College, Kanpur, Uttar Pradesh, India

ASSISTANT PROFESSOR,

OBSTETRICS & GYNAECOLOGY

GSVM MEDICAL COLLEGE , KANPUR

Mrinalini Singh, Department of Obstetrics and Gynecology, GSVM Medical College, Kanpur, Uttar Pradesh, India

SENIOR RESIDENT,

OBSTETRICS & GYNAECOLOGY

GSVM MEDICAL COLLEGE , KANPUR

References

Duley L. The global impact of pre-eclampsia and eclampsia. Sem Perinatol. 2009;33(3):130-7.

Preeclampsia. Available at: https://www.nhp.gov.in/ disease/gynaecology-and-obstetrics/preeclampsia. Accessed on 20 October 2022.

Gathiram P, Moodley J. Pre-eclampsia: its pathogenesis and pathophysiolgy. Cardiovasc J Afr. 2016;27(2):71-8.

Powe CE, Levine RJ, Karumanchi SA. Preeclampsia, a disease of the maternal endothelium: the role of antiangiogenic factors and implications for later cardiovascular disease. Circulation. 2011;123(24): 2856-69.

Budak YU, Polat M, Huysal K. The use of platelet indices, plateletcrit, mean platelet volume and platelet distribution width in emergency non-traumatic abdominal surgery: a systematic review. Biochem Med. 2016;26(2):178-93.

Xu R-L, Zheng Z-J, Ma Y-J, Hu Y-P, Zhuang S-H. Platelet volume indices have low diagnostic efficiency for predicting bone marrow failure in thrombocytopenic patients. Exp Ther Med. 2013;5(1): 209-14.

Mayrink J, Souza RT, Feitosa FE. Incidence and risk factors for Preeclampsia in a cohort of healthy nulliparous pregnant women: a nested case-control study. Sci Rep. 2019;9(1):9517.

Dadhich S, Agrawal S, Soni M. Predictive value of platelet indices in development of preeclampsia. J Safog. 2012;4(1):17-21.

Tesfay F, Negash M, Alemu J. Role of platelet parameters in early detection and prediction of severity of preeclampsia: A comparative cross-sectional study at Ayder comprehensive specialized and Mekelle general hospitals, Mekelle, Tigray, Ethiopia. PLoS One. 2019;14(11):e0225536.

Singh A, Varma R. Role of platelet distribution width (PDW) and plateletcrit in the assessment of nonthrombocytopenic preeclampsia and eclampsia. 2018;68(4):289-93.

Dhakre R, Nandmer GK, Sapkal R. Correlation of platelet indices with severity of preeclampsia: a prospective study from central India. Int J Reprod Contracept Obstet Gynecol. 2018;7(4):1416-20.

Yang SW, Cho SH, Kwon HS, Sohn IS, Hwang HS. Significance of the platelet distribution width as a severity marker for the development of preeclampsia. Eur J Obstet Gynecol Reprod Biol. 2014;175:107-11.

Thalor N, Singh K, Pujani M, Chauhan V, Agarwal C, Ahuja R. A correlation between platelet indices and preeclampsia. Hematol Transfus Cell Therapy. 2019; 41(2):129-33.

Astuti N, RIndi P, Lumbanraja S, et al. MPV, PDW, and PCT value as predictor of preeclampsia. Int J Emerg Technol Innovat Res. 2020;7(1):139-45.

Nooh AM, Abdeldayem HM. Changes in platelet indices during pregnancy as potential markers for prediction of preeclampsia development. J Obstet Gynecol. 2015;5(12):703.

Alkholy EA-M, Farag EA, Behery MA, Ibrahim MM. The significance of platelet count, mean platelet volume and platelet width distribution inpreeclampsia. AAMJ. 2013;11(1):45-9.

AlSheeha MA, Alaboudi RS, Alghasham MA, Iqbal J, Adam I. Platelet count and platelet indices in women with preeclampsia. Vasc Health Risk Manag. 2016; 12:477-80.

Annam V, Srinivasa K, Yatnatti SK, Med SDIJB. Evaluation of platelet indices and platelet counts and their significance in pre-eclampsia and eclampsia. Int J Biol Med Res. 2011;2(1):425-8.

Kamel-Ammar WAE, Abd El MAEH, Hei MAG, Mohamed MI. Evaluation of platelet indices and their significance in Preeclampsia. Nature Sci. 2014;12(3): 147-53.

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Published

2022-08-29

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Original Research Articles