Efficacy of prophylactic use of tranexamic acid in reduction of blood loss in benign hysterectomy: a randomised controlled trial

Authors

  • Manisha Nandi Department of Obstetrics and Gynecology, Mahatma Gandhi Medical College and Research Institute, Pondicherry, India
  • Lopamudra B. John Department of Obstetrics and Gynecology, Mahatma Gandhi Medical College and Research Institute, Pondicherry, India

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20221685

Keywords:

Tranexamic acid, Hysterectomy, Blood loss, Intraoperative

Abstract

Background: Aim of current study was to determine the efficacy of tranexamic acid in the reduction of blood loss during hysterectomy for benign indications.

Methods: This is a randomized controlled trial in a tertiary care teaching hospital in Pondicherry. The study population was 108. Participants were allocated into 2 groups: Group A (N=54) and group B (N=54) based on computer generated random numbers. Group A (N=54) comprised of participants undergoing hysterectomy with prophylactic intravenous tranexamic acid (1 gram in 100 ml of 0.9% normal saline) which was further subdivided into A1 (N=27) and A2 (N=27) undergoing abdominal and vaginal hysterectomy respectively. Group B: comprised of participants undergoing hysterectomy without tranexamic acid, further subdivided into B1 (N=27) and B2 (N=27) undergoing abdominal and vaginal hysterectomy respectively. The mean blood loss during the intraoperative and post-operative periods was calculated and compared between the groups.

Results: Participants in Group A who received prophylactic tranexamic acid were found to have less blood loss compared to the control population in Group B. The difference between the means was statistically significant.

Conclusions: We concluded that tranexamic acid should be considered as prophylactic treatment for hysterectomy to reduce the risk of substantial blood loss and the need for blood transfusion and early recovery.

 

References

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Jain SB. Decline in blood loss with use of tranexamic acid in cases of hysterectomy: A retrospective observational study in a teaching hospital of central India. Indian J Obstet Gynecol Res. 2021;8(1):26-30.

Nivedhana AP. Effect of prophylactic tranexamic acid on blood conservation in Indian women undergoing abdominal hysterectomy. Int J Reprod Contracept Obstet Gynecol. 2018;7(9):3538-45.

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Published

2022-06-27

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Section

Original Research Articles