DOI: http://dx.doi.org/10.18203/2320-1770.ijrcog20170017

A comparative study on the efficacy of drotaverine and valethamate on cervical dilatation during labour

Hema Sinhasane, Nishty GM

Abstract


Background: The most common cause of prolonged first stage of labour is cervical spasm leading to cervical dystocia. Many times it is observed that inspite of good uterine contractions; cervix fails to dilate or dilates very slowly. This is functional cervical dystocia.

Methods: On admission detailed history was taken, complete general physical examination was made. Careful obstetric examination confirmed the lie, presentation, position of the foetus and FHP. Vaginal examination was made and the state of cervix (Dilatation, consistency and effacement) station of the vertex and type and adequacy of the pelvis was noted.

Results: A slight increase in the cervical tear is noted in the multrigravida in Group II. The incidence of PPH was double that of Group III. This was observed specifically when the drug was given after 5cms of dilatation of cervix.

Conclusions: The maternal adverse effects were more with valethamate. Though there was transient fetal tachycardia with valethamate, the fetal outcome remained the same in all the groups.


Keywords


Cervical dystocia, Drotaverine, Valethamate

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References


Rohwor AC, Khondowe O, Young T. Antispasmodics for labour. Cochrane Database Syst Rev. 2013 Jun 5;(6):CD009243.

Madhu C, Mahavarkar S Bhave S. A randomised controlled study comparing Drotaverine hydrochloride and Valethamate bromide in the augmentation of labour. Arch Gynecol Obstet. 2010;282(1):11-5.

Gupta B, Nellore V, Mittal S. Drotaverine hydrochloride versus hyoscine-N-butylbromide in augmentation of labor. Int J Gynaecol Obstet. 2008;100(3):244-7.

Ibrahim MI, Alzeeniny HA, Ellaithy MI, Salama AH, Abdellatif MA. Int J Gynaecol Obstet. 2014;124(2):112-7.

Singh KC, Jain P, Goel N, Saxena A. Drotaverine hydrochloride for augmentation of labor. Int J Gynecol Obstet. 2004;84(1):17-22.

Devinder K, Ravinder K. Comparison of drotaverine and epidosin in first stage of labor. J Obstet Gynecol India. 2003;53(5):449-52.

Khosla AH, Bala I, Dahiya K, Sangwan K. A comparative study of the efficacy of valethamate bromide with drotaverine in normal labor. J Obstet Gynecol India. 2003;53(6):568-70.

Mishra SL, Toshniwal A. Effect of drotaverine on cervical dilatation: A comparative study with epidosin (valethamate bromide). J Obstet Gynecol India. 2002;52(3):76-9.

Demeter J, Blasko S. The effect of intramuscularly administered drotaverine on the dilatation stage of uncomplicated deliveries. Obstet Gynecol. 1998;3:723-37.