DOI: http://dx.doi.org/10.18203/2320-1770.ijrcog20215068

Maternal serum CA-125 repeated measurement during pregnancy and how to use as a prognostic factor of first trimester pregnancy outcome

Nasreen S. Badr, Samira Y. El Mallah, Magda I. El Mahdy, Hanaa F. Ahmad

Abstract


Background: The aim of this study was to estimate the prognostic efficacy of repeated measurement of maternal serum CA125 in first trimester threatened miscarriage.

Methods: Prospective case control study was conducted in the outpatient clinic. 100 pregnant women were divided into 50 women with normal course of pregnancy, and the other 50 were subdivided into 25 pregnant women with lower abdominal pain without vaginal bleeding and 25 presented with minimal vaginal bleeding. Repeated measuring of serum CA125 was done for each case on the 5th, 10th weeks of gestation.

Results: Findings of this study suggested the possibility of using serum CA-125 for determining the prognosis of first trimester threatened miscarriage with cut-off value of CA125 38.25 U/ml on the 5th week of gestation and 53 U/ml on the 10th week of gestation in patients presented with pain only but in patients presented with minimal vaginal bleeding the cut-off value of CA125 on the 5th week of gestation become 45.6 U/ml and 68 U/ml on the 10th week of gestation.

Conclusions: CA125, on its own, can discriminate between continued and non-continued pregnancy.

 


Keywords


CA125, Pregnancy, Threatened miscarriage

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References


Katsikis I, Rousso D, Farmakiotis D, Kourtis A, Kandarakis E, Panidis D. Receiver operator characteristics and diagnostic value of progesterone and CA-125 in the prediction of ectopic and abortive intrauterine gestations. Eur J Obstet Gynecol Reprod Biol. 2006;125:226-32.

Madendag Y, Col-Madendag I, Kanant-Pekas M, Danisman N. Predictive power of serum CA-125 and LDH in the outcome of first trimester pregnancies with human chronic gonadotropin levels below discriminatory zone. Arch Gynecol Obstet. 2009;279(5):826-30.

Schmidt T, Rein DT, Foth D, Eibach H, Kurbacher C, Mallmann P, et al. Prognostic value of repeated serum CA 125 measurements in first trimester pregnancy. Eur J Obstet Gynecol Reprod Biol. 2001;97(2):168-73.

Yadav K, Ojha P, Chopra A. Comparison of maternal serum CA-125 and ultrasonography findings as a prognostic marker in threatened abortion. Int J Reprod Contracept Obstet Gynecol. 2021;10:2253-8.

Eid M, Abdallah AK. Cancer antigen 125 (CA-125) and serum progesterone as predictors of fate of threatened abortion: case control study. Int J Fertil Steril. 2017;7(4).

Maged AM, Mostafa WA. Biochemical and ultrasonographic predictors of outcome in threatened abortion. Middle East Fertil Soc J. 2013;18(3):177- 81.

Bon GG, Kenemans P, Verstraeten AA, Go S, Philipi PA, Van Kamp GJ, et al. Maternal serum Ca125 and Ca15-3 antigen levels in normal and pathological pregnancy. Fet Diagn Therap. 2001;16(3):166-72.

Kaminski K, Korczala KZ, Fiegler P. Level of CA-125 antigen in serum of first trimester normal and miscarried pregnancy. Wiad Lek. 2002;55(5-6):310-4.

Foth D, Romer T. Maternal CA-125 serum level in intrauterine pregnancy and abortion in the first trimester. Zentralbl Gynakol. 2000;122(4):217-21.

Mohamady MA, Fattah GA, Elkattan E, Byoumy R, Hamed DA. Correlation of serum CA-125 and progesterone levels with ultrasound markers in the prediction of pregnancy outcome in threatened miscarriage. Int J Fertil Steril. 2016;9(4):506-11.

Fiegler P, Katz M, Kaminski K, Rudol G. Clinical value of a single serum CA-125 level in women with symptoms of imminent abortion during the first trimester of pregnancy. Reprod Med. 2003;48(12):982-8.

Ghoneim MR, El-Shahat AM, El-Essawy LY. Maternal serum CA 125 in first trimester threatened abortion. Ain Shams Medical J. 2005;56(1,2,3):247-57

Salem MR, Hassan FR, Abd El Maqsud KA. The value of maternal serum β-HCG and CA 125 Levels with trans-vaginal color Doppler of the uterine arteries in assessment of cases of first trimesteric threatened abortion. Cairo University. 2005;167

Scarpellini F, Mastrone M, Sbracia M, Scarpellini L. Serum CA-125 and first trimester abortion. Int J Gynaecol Obstet. 1995;49:259-64.

Azougi G, Yaronovski A, Zohar S, Ben-Shlomo I. CA-125 is elevated in viable pregnancies destined to be miscarried: a prospective longitudinal study. Fertil Steril. 1996;65(5):1059-61.

Check JH, Nowroozi K, Winkel CA, Johnson T, Seefried L. Serum CA125 level in early pregnancy and subsequent spontaneous abortion. Obstet Gynecol. 1990;75:742-4.

Ocer F, Bese T, Saridogan E, Aydinli K, Atasu T. The prognostic significance of maternal serum CA-125 measurement in threatened abortion. Eur J Obstet Gynecol Reprod Biol. 1992;46:137-42.