DOI: http://dx.doi.org/10.18203/2320-1770.ijrcog20215113

Synchronous papillary endometrial and ovarian cancer in a 64-year-old woman

Ganesh B. Bharaswadkar, Nalan Babacan

Abstract


Obesity, nulliparity, and comparatively younger age may attribute a “hormonal field effect” which leads to the development of synchronous endometrioid cancers. The morphological unit consisting of the uterus, fallopian tubes, and ovary as part of the Mullerian system may explain the synchronous appearance of these malignancies. Synchronous endometrial and ovarian cancer (SEOC) is defined as the simultaneous presence of these dual cancers at the time of diagnosis as opposed to metachronous cancer where these two cancers are diagnosed at different chronologic time points. Synchronous malignancies in the female genital tract are very rare entities. Synchronous endometrial and ovarian tumors must be differentiated from either primary endometrium or ovarian tumors with metastasis. The landmark criteria for diagnosing such cases have been laid down by Ulbright and Roth.


Keywords


Synchronous papillary endometrial, Ovarian cancer, Mullerian system

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References


Matsuo K, Machida H, Blake EA, Holman LL, Rimel BJ, Roman LD, Wright JD. Trends and outcomes of women with synchronous endometrial and ovarian cancer. Oncotarget. 2018;9(47):28757-71.

Kelemen LE, Rambau PF, Koziak JM, Steed H, Köbel M. Synchronous endometrial and ovarian carcinomas: predictors of risk and associations with survival and tumor expression profiles. Cancer Causes Control. 2017;28:447-57.

Zaino R, Whitney C, Brady MF, DeGeest K, Burger RA, Buller RE. Simultaneously detected endometrial and ovarian carcinomas—a prospective clinicopathologic study of 74 cases: a gynecologic oncology group study. Gynecol Oncol. 2001;83:355-62.

Ulbright TM, Roth LM. Metastatic and independent cancers of the endometrium and ovary: a clinicopathologic study of 34 cases. Hum Pathol. 1985;16:28-34.

Scully R, Young R, Clement P. Tumors of the Ovary, Maldeveloped Gonads, Fallopian Tube and Broad Ligament: Atlas of Tumor Pathology. Bethesda: Armed Forces Institute of Pathology. 1998.

Scully RE, Young RH, Clement PB. Tumors of the Ovary, Maldeveloped Gonads, Fallopian Tube, and Broad Ligament: Atlas of Tumor Pathology (Afip Atlas of Tumor Pathology No. 23). Amer Registry of Pathology, Silver Spring, MD. 1998.

Centers for Disease Control and Prevention: National Center for Health Statistics. 2015. Available at: https://www.cdc.gov/nchs/%20data/hestat/overweight/overweight_adult.htm. Accessed on 12 July 2020.

National Cancer Institute: Surveillance, Epidemiology, and End Results Program. Cancer stat facts - endometrial cancer. 2017. Available at: https://seer.cancer.gov/statfacts/html/corp.html. Accessed on 12 July 2020:

National Cancer Institute: Surveillance, Epidemiology, and End Results Program. Cancer stat facts: ovarian cancer. 2017. Available at: https://seer.cancer.gov/statfacts/html/ovary.html. Accessed on 12 July 2020.

Morris CR, Rodriguez AO, Epstein J, Cress RD. Declining trends of epithelial ovarian cancer in California. Gynecol Oncol. 2008;108:207-13.

Yang HP, Anderson WF, Rosenberg PS. Ovarian cancer incidence trends in relation to changing patterns of menopausal hormone therapy use in the United States. J Clin Oncol. 2013;31:2146-51.

Eifel P, Hendrickson M, Ross J, Ballon S, Martinez A, Kempson R. Simultaneous presentation of carcinoma involving the ovary and the uterine corpus. Cancer. 1982;50:163-70.

Niskakoski A, Pasanen A, Porkka N. Converging endometrial and ovarian tumorigenesis in Lynch syndrome: shared origin of synchronous carcinomas. Gynecol Oncol. 2018;150:92-8.

Makris G, Manousopoulou G, Battista M, Salloum I, Chrelias G, Chrelias C: Synchronous Endometrial and Ovarian Carcinoma: A Case Series. Case Rep Oncol. 2017;10:732-6.

de la Noval BD. Factors associated with Synchronous Endometrial and Ovarian Cancer, Review of a Case. Crit Care Obst Gyne. 2016;2:4.